教授，国家杰出青年基金获得者
电话：021-31242088
邮箱：zhaotj@fudan.edu.cn
地址：复旦大学2号交叉学科楼D7021室

个人简介

1998年进入山东大学，2002年获得学士学位；2007年获得清华大学博士学位；2007-2012年，在美国西南医学中心分子遗传系进行博士后研究；2012-2014年，任美国西南医学中心分子遗传系助理教授（research track）；2014-2019年，任厦门大学生命科学学院教授；2019-今，任复旦大学代谢与整合生物学研究院教授。2021年获得国家杰出青年科学基金项目资助。

主要研究方向

主要从事代谢性疾病生理和分子机制方面的研究。目前的研究工作主要集中在两个方面：1、蛋白质棕榈酰化转移酶在机体代谢调控方面的作用及其分子机制；2、脂肪细胞分化发育过程中关键调控因子的鉴定。

课题组成员

荣誉及获奖情况

• 2011年  Award for Excellence in Postdoctoral Research, UT Southwestern Medical Center

• 2006年  教育部自然科学一等奖 (第五完成人)

代表性成果

1. Wang J#, Li DL#, Zheng LF, Ren SU, Huang ZQ, Tao Y, Liu Z, Shang Y, Pang D, Guo H, Zeng T, Wang H, Huang H, Du X, Ye H, Zhou HM, Li P, Zhao TJ*. (2024) Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration. Dev Cell, 59(3): 384-399.

2. Weng L#, Tang WS#, Wang X#, Gong Y#, Liu C, Hong NN, Tao Y, Li KZ, Liu SN, Jiang W, Li Y, Yao K, Chen L, Huang H, Zhao YZ, Hu ZP, Lu Y, Ye H, Du X, Zhou H*, Li P*, Zhao TJ*. (2024) Surplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy. Nat Commun, 15(1): 133.

3. Wang J, Zheng LF, Ren S, Li DL, Chen C, Sun HH, Liu LY, Guo H*, Zhao TJ*. (2023) ARF6 plays a general role in targeting palmitoylated proteins from the Golgi to the plasma membrane. J Cell Sci, 136(15):  jcs261319.

4. Guo H#, Wang J#, Ren S#, Zheng LF#, Zhuang YX, Li DL, Sun HH, Liu LY, Xie C, Wu YY, Wang HR, Deng X, Li P, Zhao TJ* (2022). Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system. Nature Commun, 13: 6004.

5. Wang J, Liang G*, Zhao TJ*. (2022) Adipose triglyceride lipase: The first transacylase for FAHFAs. Life Metabolism, 1: loac016.

6. Wang X#, Liu SY#, Hu GS, Wang HY, Zhang GL, Cen X, Xiang ST, Liu W, Li P, Ye H, Zhao TJ*. (2022) DDB1 prepares brown adipocytes for cold-induced thermogenesis. Life Metabolism, 1, 1: 39-53.

7. Wang X#, Wang HY#, Hu GS#, Tang WS, Weng L, Zhang Y, Guo H, Yao SS, Liu SY, Zhang GL, Han Y, Liu M, Zhang XD, Cen X, Shen HF, Xiao N, Liu CQ, Wang HR, Huang J, Liu W, Li P, Zhao TJ*. (2021) DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Cell Rep, 35: 109281.

8. Tang WS#, Weng L#, Wang X#, Liu CQ#, Hu GS, Yin ST, Tao Y, Hong NN, Guo H, Liu W, Wang HR, Zhao TJ*. (2021) The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity. Cell Rep, 36: 109314.

9. Hao JW#, Wang J#, Guo H#, Zhao YY, Sun HH, Li YF, Lai XY, Zhao N, Wang X, Xie C, Hong L, Huang X, Wang HR, Li CB, Liang B, Chen S*, Zhao TJ*. (2020) CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis. Nat Commun, 11: 4765.

10. Wang J#, Hao JW#, Wang X#, Guo H#, Sun HH, Lai XY, Liu LY, Zhu M, Wang HY, Li YF, Yu LY, Xie C, Wang HR, Mo W, Zhou HM, Chen S, Liang G, Zhao TJ*. (2019) DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Cell Rep, 26: 209-221.