青年研究员

 电话：021-31242929

 邮箱：guanlin_wang@fudan.edu.cn

 办公地址：复旦大学2号交叉学科楼D7025室

个人简介

2012年9月至2018年6月，中国科学院遗传与发育生物学研究所，理学博士

2019年1月至2022年2月，牛津大学MRC Weatherall Institute of Molecular Medicine, 博士后

2021年1月至2022年2月，牛津大学Wolfson学院, Junior Research Fellow

2022年3月起，复旦大学代谢与整合生物学研究院, 青年研究员

主要研究方向

围绕基因组分子进化、单细胞转录组、单细胞表观组和空间转录组学在肥胖等代谢综合征以及纤维化疾病的理论与应用方面展开研究，具体包括：

1）致病基因在单细胞尺度上的分子进化过程；

2）肥胖、青少年肥胖等代谢综合征的多组学研究；

3）多组织(骨髓、肝、肾)纤维化疾病的多组学研究；

4）生物学大数据多组学分析、整合工具的开发。

荣誉及获奖情况

• 2021 Oxford Centre for Hematology Pump Priming Award, 牛津大学

• 2021 Medical Sciences Pump Priming Fund, 牛津大学

• 2021 Academic fund, 牛津大学，Wolfson学院

• 2020 BRC Training Grant, 牛津大学

• 2017 中国科学院院长奖

• 2016 国家奖学金

• 2016 New Investigator Award finalist fellowship, International Congress for Obesity (ICO) and World Obesity Federation

代表性成果

1. Wang G, Speakman JR*. Analysis of positive selection at single nucleotide polymorphisms associated with body mass index does not support the “thrifty gene” hypothesis. Cell Metabolism, 2016, 24(4), 531-541. (F1000 Prime recommended)

2. Wang G, Li B, Zhang X, Niu C, Li J, Li L, Speakman JR*. No seasonal variation in physical activity of Han Chinese living in Beijing. International Journal of Behavioral Nutrition and Physical Activity, 2017, 14(1), 48. 

3. Psaila B#,*, Wang G#, Rodriguez-Meira A, Li R, Heuston EF, Murphy L, Yee D, Hitchcock I, Sousos N, O'Sullivan J, Anderson S, Senis Y, Weinberg O, Calicchio M, NIH Intramural Sequencing Center, Iskander D, Royston D, Milojkovic D, Roberts I, Bodine D, Thongjuea S *, Mead A*. Single-cell analyses reveal megakaryocyte-biased hematopoiesis in myelofibrosis and identify mutant clone-specific targets. Molecular Cell, 2020, 78(3), 477-492. (#co-first author) (Faculty Opinions recommended)

4. Roy A#, *, Wang G#, Iskander D, O'Byrne S, Elliott N, O'Sullivan J, Buck G, Heuston EF, Wen WX, Rodriguez-Meira A, Hua P, Karadimitris A, Mead A, Bodine D, Roberts I, Psaila B*, Thongjuea S*. Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development. Cell Reports, 2021, 36(11), 109698. (#co-first author)

5. Iskander D, Wang G, Heuston EF, Christodoulidou C, Psaila B, Ponnusamy K, Ren H, Mokhtari Z, Robinson M, Chaidos A, Trivedi P, Trasanidis N, Katsarou A, Szydlo R, Palii C, Zaidi M, Al-Oqaily Q, Caputo V, Roy A, Harrington Y, Karnik L, Naresh K, Mead A, Thongjuea S, Brand M, Fuente J, Bodine D, Roberts I, Karadimitris A*. Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia. Science Translational Medicine, 2021, 13(610), eabf0113.

6. COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium, A blood atlas of COVID-19 defines hallmarks of disease severity and specificity, 2022, Cell, 185, 916–938.

7. Lin X, Wang G. Development of a RNAi-based release of insects carrying a dominant lethal (RIDL) system in Drosophila melanogaster. Science Bulletin, 2015, 60(3), 356-362.

8. Wu Y, Green CL, Wang G, Yang D, Li L, Li B, Wang L, Li M, Li J, Xu Y, Zhang X, Niu C, Hu S, Togo J, Mazidi M, Derous D, Douglas A, Speakman JR*. Effects of dietary macronutrients on the hematic transcriptome and serum metabolome in mice. Ageing Cell, 2022, e13585.

9. Li B#, Li L#, Li M#, Lam SM#, Wang G, Wu Y, Zhang H, Niu C, Zhang X, Liu X, Hambly C, Jin W, Shui G, Speakman JR*. Microbiota depletion impairs thermogenesis of brown adipose tissue and browning of white adipose tissue. Cell Reports, 2019, 26(10), 2720-2737.

10. Hu S#, Wang L#, Yang D#, Li L#, Togo J#, Wu Y#, Liu Q, Li B, Li M, Wang G, Zhang X, Niu C, Li J, Xu Y, Couper E, Davis A, Mazidi M, Douglas A, Luo Li, Wang S, Douglas A, Speakman JR*. Dietary fat, but not protein or carbohydrate, regulates energy intake and causes adiposity in mice. Cell Metabolism, 2018, 28(3), 415-431.