青年研究员

邮箱：guanlin_wang@fudan.edu.cn

办公地址：上海市杨浦区湾谷科技园2期D3座1303室

个人简介

2022年3月至今，复旦大学代谢与整合生物学研究院, 青年研究员

2021年1月至2022年2月，牛津大学Wolfson学院, Junior Research Fellow

2019年1月至2022年2月，牛津大学MRC Weatherall Institute of Molecular Medicine, 博士后 （合作导师：Adam Mead教授）

2012年9月至2018年6月，中国科学院遗传与发育生物学研究所，理学博士（导师：John Speakman院士）

主要研究方向

本课题组基于单细胞转录组、空间转录组、基因组、体外功能验证等技术，开发基于AI技术的计算生物学新方法来识别生理、病例过程中的代谢特征，解析代谢性疾病的发生与调控过程。我们侧重对研究的科学问题“量体裁衣”式的进行数据采集、数据分析以及算法开发，从“精准分析”的层面上推动精准医疗。目前课题方向包括：1）基于单细胞转录组与空间转录组数据解析肥胖的发生发展；2）运动调控肥胖的机制研究；3）单细胞多组学与空间转录组数据算法开发、构建虚拟细胞模型等。

课题组招收有科研理想的干&湿实验方向研究生、博士后，并为加入的成员提供系统的计算生物学的培训。

荣誉及获奖情况

• 2021 Oxford Centre for Hematology Pump Priming Award, 牛津大学

• 2021 Medical Sciences Pump Priming Fund, 牛津大学

• 2021 Academic fund, 牛津大学，Wolfson学院

• 2020 BRC Training Grant, 牛津大学

• 2017 中国科学院院长奖

• 2016 国家奖学金

• 2016 New Investigator Award finalist fellowship, International Congress for Obesity (ICO) and World Obesity Federation

代表性成果

（实验室成员，#共同第一作者，* 通讯作者）

1.Dong P, Ding S, Wang G*. Optimized upstream analytical workflow for single-nucleus transcriptomics in main metabolic tissues. Life Metabolism. 2025, loaf010. https://doi.org/10.1093/lifemeta/loaf010. Epub 2025 April 2.

2.Li R#, Colombo M#, Wang G#,*, Rodriguez-Romera A, Benlabiod C, Jooss NJ, O'Sullivan J, Brierley CK, Clark SA, Pérez Sáez JM, Fernández PA, Schoof EM, Porse B, Meng Y, Khan AO, Wen S, Dong P, Zhou W, Sousos N, Murphy L, Clarke M, Olijnik AA, Wong ZC, Karali CS, Sirinukunwattana K, Ryou H, Norfo R, Cheng Q, Carrelha J, Ren Z, Thongjuea S, Rathinam VA, Krishnan A, Royston D, Rabinovich GA, Mead AJ*, Psaila B*. A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis. Science Translational Medicine. 2024 Oct 9;16(768): eadj7552.

3.Huang Y#, Wang A#, Zhou W, Li B, Zhang L, Rudolf AM, Jin Z, Hambly C, Wang G*, Speakman JR*. Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice. Nature Communications, 2024 Mar 16;15(1):2382.

4.Bao Y, Wang G*, Li H*. Approaches for studying human macrophages. Trends in Immunology, 2024 Apr;45(4):237-247.

5.Wang Z#, Wu Z#, Wang H#, Feng R#, Wang G#,*, Li M#, Wang S-Y#, Chen X#, Su Y, Wang J, Zhang W, Bao Y, Lan Z, Song Z, Wang Y, Luo X, Zhao L, Hou A, Tian S, Gao H, Miao W, Liu Y, Wang H, Yin C, Ji Z-L, Feng M, Liu H, Diao L, Amit I, Chen Y, Zeng Y, Ginhoux F*, Wu X*, Zhu Y*, Li H*. An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development. Cell, 2023/9/28, 186(20), 4454-4471. e19. (Faculty Opinions recommended)

-Highlight by Cell Research, Science Immunology, Trends in Immunology, Cellular & Molecular Immunology等

-入选《科技日报》2023年国内十大科技新闻http://digitalpaper.stdaily.com/http_www.kjrb.com/kjrb/html/2023-12/26/content_564676.htm?div=-1

博士、博后期间：

1.Wang G, Speakman JR*. Analysis of positive selection at single nucleotide polymorphisms associated with body mass index does not support the “thrifty gene” hypothesis. Cell Metabolism, 2016, 24(4), 531-541. (F1000 Prime recommended)

2.Psaila B#,*, Wang G#, Rodriguez-Meira A, Li R, Heuston EF, Murphy L, Yee D, Hitchcock I, Sousos N, O'Sullivan J, Anderson S, Senis Y, Weinberg O, Calicchio M, NIH Intramural Sequencing Center, Iskander D, Royston D, Milojkovic D, Roberts I, Bodine D, Thongjuea S *, Mead A*. Single-cell analyses reveal megakaryocyte-biased hematopoiesis in myelofibrosis and identify mutant clone-specific targets. Molecular Cell, 2020, 78(3), 477-492. (#co-first author) (Faculty Opinions recommended)

3.Roy A#, *, Wang G#, Iskander D, O'Byrne S, Elliott N, O'Sullivan J, Buck G, Heuston EF, Wen WX, Rodriguez-Meira A, Hua P, Karadimitris A, Mead A, Bodine D, Roberts I, Psaila B*, Thongjuea S*. Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development. Cell Reports, 2021, 36(11), 109698. (#co-first author)

4.Wang G, Wen WX, Mead AJ, Roy A, Psaila B, Thongjuea S*. Processing single-cell RNA-seq datasets using SingCellaR. STAR Protoc. 2022 Apr 1;3(2):101266. doi: 10.1016/j.xpro.2022.101266.

5.Wang G, Li B, Zhang X, Niu C, Li J, Li L, Speakman JR*. No seasonal variation in physical activity of Han Chinese living in Beijing. International Journal of Behavioral Nutrition and Physical Activity, 2017, 14(1), 48. 

6.Wang G, Ekeleme-Egedigwe CA, El Hamdouchi A, Sauciuvenaite J, Bissland R, Djafarian K, Ojiambo R, Ramuth H, Holasek S, Lackner S, Diouf A, Hambly C, Vaanholt LM, Cao M, Hacker M, Kruger HS, Seru T, Faries MD, Speakman JR*. Beauty and the Body of the Beholder: Raters' BMI Has Only Limited Association with Ratings of Attractiveness of the Opposite Sex. Obesity (Silver Spring). 2018 Mar;26(3):522-530.

7.Lin X*, Wang G. Development of a RNAi-based release of insects carrying a dominant lethal (RIDL) system in Drosophila melanogaster. Science Bulletin, 2015, 60(3), 356-362.