全职PI
赵同金

 教授 国家杰出青年基金获得者

电话:021-31242088
邮箱:zhaotj@fudan.edu.cn
地址:复旦大学2号交叉学科楼D7021室

  


个人简介

1998年进入山东大学,2002年获得学士学位;2007年获得清华大学博士学位;2007-2012年,在美国西南医学中心分子遗传系进行博士后研究;2012-2014年,任美国西南医学中心分子遗传系助理教授(research track);2014-2019年,任厦门大学生命科学学院教授;2019-今,任复旦大学代谢与整合生物学研究院教授。2021年获得国家杰出青年科学基金项目资助。

主要研究方向

主要从事代谢性疾病生理和分子机制方面的研究。目前的研究工作主要集中在两个方面:1、蛋白质棕榈酰化转移酶在机体代谢调控方面的作用及其分子机制;2、脂肪细胞分化发育过程中关键调控因子的鉴定。

荣誉及获奖情况

  • 2011年 Award for Excellence in Postdoctoral Research, UT Southwestern Medical Center

  • 2006年 教育部自然科学一等奖 (第五完成人)

代表性成果

  1. Wen-Shuai Tang#, Li Weng#, Xu Wang#, Chang-Qin Liu#, Guo-Sheng Hu, Shu-Ting Yin, Ying Tao, Ni-Na Hong, Huiling Guo, Wen Liu, Hong-Rui Wang, Tong-Jin Zhao*. The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity. Cell Reports, 2021, 36(1): 109314.

  2. Xu Wang#, Hao-Yan Wang#, Guo-Sheng Hu#, Wen-Shuai Tang, Li Weng, Yuzhu Zhang, Huiling Guo, Shan-Shan Yao, Shen-Ying Liu, Guo-Liang Zhang, Yan Han, Min Liu, Xiao-Dong Zhang, Xiang Cen, Hai-Feng Shen, Nengming Xiao, Chang-Qin Liu, Hong-Rui Wang, Jing Huang, Wen Liu, Peng Li, Tong-Jin Zhao*. DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Cell Reports, 2021, 35(12): 109281.

  3. Jian-Wei Hao#, Juan Wang#, Huiling Guo#, Yin-Yue Zhao, Hui-Hui Sun, Yi-Fan Li, Xiao-Ying Lai, Ning Zhao, Xu Wang, Changchuan Xie, Lixin Hong, Xi Huang, Hong-Rui Wang, Cheng-Bin Li, Bin Liang, Shuai Chen*, Tong-Jin Zhao*.  CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis. Nat Commun, 2020, 11: 4765.

  4. Ou Z#, Ma Y#, Sun Y#, Zheng G, Wang S, Xing R, Chen X, Han Y, Wang J, Lu QR*, Zhao TJ*, Chen Y*. A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism. Cell Rep, 2019, 26: 2984-2997.

  5. Wang J#, Hao JW#, Wang X#, Guo H#, Sun HH, Lai XY, Liu LY, Zhu M, Wang HY, Li YF, Yu LY, Xie C, Wang HR, Mo W, Zhou HM, Chen S, Liang G, Zhao TJ*. DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Cell Rep, 2019, 26: 209-221.

  6. Liu M#, Zeng T#, Zhang X#, Liu C, Wu Z, Yao L, Xie C, Xia H, Lin Q, Xie L, Zhou D, Deng X, Chan HL, Zhao TJ*, Wang HR*. ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage. Nat Commun, 2018, 9: 4139.

  7. Zhang Y, Fang F, Goldstein JL*, Brown MS*, Zhao TJ. Reduced autophagy in livers of fasted, fat-depleted ghrelin-dificient mice: reversal by growth hormone. Proc Natl Acad Sci USA, 2015,112: 1226-1231.

  8. McFarlane MR, Brown MS*, Goldstein JL*, Zhao TJ. Induced Ablation of Ghrelin Cells in Adult Mice Does Not Decrease Food Intake, Body Weight, or Response to High-Fat Diet. Cell Metab, 2014, 20: 54-60.

  9. Li RL#, Sherbet DP#, Elsbernd BL, Goldstein JL*, Brown MS*, Zhao TJ. Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids. J Biol Chem, 2012,  287:  17942-17950.

  10. Zhao TJ#, Sakata I#, Li RL, Liang G, Richardson JA, Brown MS*, Goldstein JL*, Zigman JM*. Ghrelin secretion stimulated by β1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice. Proc Natl Acad Sci U S A, 2010, 107: 15868-15873. (From the cover)

  11. Zhao TJ#, Liang G#, Li RL, Xie X, Sleeman MW, Murphy AJ, Valenzuela DM, Yancopoulos GD, Goldstein JL*, Brown MS*. Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc Natl Acad Sci U S A, 2010, 107: 7467-7472.  (From the cover)

  12. Yang J#, Zhao TJ#, Goldstein JL*, Brown MS*. (2008) Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proc Natl Acad Sci U S A, 2008, 105: 10750-10755. (Co-first author)

  13. Qi J#, Gong J#, Zhao TJ#, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM*, Li P*. Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. EMBO J, 2008, 27: 1537-1548. (Co-first author)