全职PI
李蓬

教授,中国科学院院士,发展中国家科学院院士,国家杰出青年基金获得者
电话:021-31242076
邮箱:peng_li@fudan.edu.cn
地址:复旦大学2号交叉学科楼E7006-2室

 


个人简介

1983年进入北京师范大学,1987年获得学士学位;1988年通过CUSBEA项目留学美国;1995年获美国加州大学圣地亚哥分校生物医学博士学位。随后在新加坡国立大学分子与细胞生物学研究所、美国达拉斯西南医学中心、霍华德休斯医学研究所进行博士后研究;1997-2002年任新加坡分子和细胞生物学研究所助理教授及研究室主任;2003-2005年历任香港科技大学生物系助理教授、副教授。2006年全职回到清华大学工作,任清华大学生命科学学院学术委员会主任。2018年出任复旦大学代谢与整合生物学研究院院长。2016年11月至今兼职国家自然科学基金委生命学部主任。曾担任国际脂生物学会指导委员会委员和国家自然科学基金委生命学部生理学科咨询委员,中国生化和分子生物学会理事,北京生化和分子生物学会副理事长,现任中国生物物理学会副理事长。

主要研究方向

主要研究脂代谢调控的分子机制,脂滴的形成、融合、动态变化及与内质网、线粒体等细胞器的相互作用,以及肥胖、糖尿病、脂肪肝等代谢性疾病的发生和发展机制。

课题组成员

陈丰荣 青年研究员

杨天舒 青年研究员

杨慧 青年副研究员

王嘉希 青年副研究员

荣誉及获奖情况

  • 2016年  当选发展中国家科学院(TWAS)院士

  • 2015年  当选中国科学院院士

  • 2012年  何梁何利基金生命科学领域科学与技术进步奖

  • 2009年  国家杰出青年基金资助

  • 2008年  亚太分子生物学网络第一届阿瑟·科恩伯格纪念讲演奖(Arthur Kornberg Memorial Lecture award)

  • 1999年  新加坡青年科学家奖

代表性成果

  1. Du X#, Zhou L#, Aw Y, Mak HY, Xu Y, Rae J, Wang W, Zadoorian A, Hancock S, Osborne B, Chen X, Wu JW, Turner N, Parton RG, Li P*, Yang H*. ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets. J Cell Biol, 2020, 219(1): e201905162.

  2. Chen FJ, Yin Y, Chua BT, Li P*. CIDE family proteins control lipid homeostasis and the development of metabolic diseases. Traffic, 2020,21(1): 94-105.

  3. Lv X#, Liu J#, Qin Y, Liu Y, Jin M, Dai J, Chua BT, Yang H, Li P*. Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysis. Biochim Biophys Acta Mol Cell Biol Lipids, 2019, 1864(2): 113-127.

  4. Li Q, Zhao Q, Zhang J, Zhou L, Zhang W, Chua B, Chen Y, Xu L*, Li P*. The Protein Phosphatase 1 Complex Is a Direct Target of AKT that Links Insulin Signaling to Hepatic Glycogen Deposition. Cell Rep, 2019, 28(13): 3406-3422.

  5. Su L#, Zhou L#, Chen FJ, Wang H, Qian H, Sheng Y, Zhu Y, Yu H, Gong X, Cai L, Yang X, Xu L, Zhao TJ, Li JZ, Chen X*, Li P*.  Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites. EMBO J, 2019, 38(8): e100156.

  6. Wang J, Yan C, Xu C, Chua BT, Li P*, Chen FJ*. Polybasic RKKR motif in the linker region of lipid droplet (LD)-associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids. J Biol Chem, 2018, 293(50): 19330-19343.

  7. Zhou L#, Yu M#, Arshad M, Wang W, Lu Y, Gong J, Gu Y, Li P*, Xu L*. Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes. Diabetes, 2018, 67(10): 1935-1948.

  8. Xu D#, Li Y#, Wu L#, Li Y, Zhao D, Yu J, Huang T, Ferguson C, Parton RG, Yang H, Li P*. Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions. J Cell Biol, 2018: 975-995.

  9. Qian H, Chen Y, Nian Z, Su L, Yu H, Chen FJ, Zhang X, Xu W, Zhou L, Liu J, Yu J, Yu L, Gao Y, Zhang H, Zhang H, Zhao S, Yu L, Xiao RP, Bao Y, Hou S, Li P, Li J, Deng H, Jia W, Li P*. HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage. J Clin Invest, 2017, 127: 1353-1369.

  10. Zhou L, Park SY, Xu L, Xia X, Ye J, Su L, Jeong KH, Hur JH2, Oh H, Tamori Y, Zingaretti CM, Cinti S, Argente J, Yu M, Wu L, Ju S, Guan F,Yang H, Choi CS, Savage DB, Li P*. Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27 deficient mice. Nat Commum, 2015, 6: 5949.

  11. Wu L, Xu D, Zhou L, Xie B, Yu L, Yang H, Huang L, Ye J, Deng H, Yuan YA, Chen S, Li P*. Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth. Dev Cell, 2014, 30: 378-393.

  12. Zhang S, Shui G, Wang G, Wang C, Sun S, Zouboulis CC, Xiao R, Ye J, Li W, Li P*. Cidea control of lipid storage and secretion in mouse and human sebaceous Glands, Mol Cell Biol, 2014, 34: 1827-1838.

  13. Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, Gao J, Wu J, Yang H, Yang M and Li P*. Perilipin1 promotes unilocular lipid droplet formation through activation of Fsp27 in adipocytes. Nat Commum, 2013, 4: 1594.

  14. Xu L, Zhou L, Li P*. CIDE proteins and lipid metabolism. Arterioscler Thromb Vasc Biol, 2012, 32: 1094-1098.

  15. Zhou L, Xu L, Ye J, Li D, Wang W, Li X, Wu L, Wang H, Guan F, Li P*. Cidea promotes hepatic steatosis by sensing dietary fatty acids. Hepatology, 2012, 56: 95-107.

  16. Wang W, Lv N, Zhang S, Shui G, Qian H, Zhang J, Chen Y, Ye J, Xie Y, Shen Y, Wenk MR, Li P*. Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. Nat Med, 2012, 18: 235-243.

  17. Gong J, Sun Z, Wu L, Xu W, Schieber N, Xu D, Shui G, Yang H, Parton RG, Li P*. Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. J Cell Biol, 2011, 195: 953-963.

  18. Ye J, Li JZ, Liu Y, Li X, Yang T, Ma X, Li Q, Yao Z, Li P*. Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B. Cell Metab, 2009, 9: 177-190.

  19. Qi J, Gong J, Zhao T, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM, Li P*. Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. EMBO J, 2008, 27: 1537-1548.

  20. Li JZ, Ye J, Xue B, Qi J, Zhang J, Zhou Z, Li Q, Wen Z, Li P*. Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation. Diabetes, 2007, 56: 2523-2532.

  21. Zhou Z, Yon Toh S, Chen Z, Guo K, Ng CP, Ponniah S, Lin SC, Hong W, Li P*. Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genetics, 2003, 35: 49-56.

  22. Chua BT, Volbracht C, Ta KOn, Li R, Yu V and Li P*. Mitochondrial translocation of cofilin is an early step in apoptosis induction. Nat Cell Biol, 2003, 5: 1083-1089.

  23. Li P, Nijhawan D, Budihardio I, Srinivasula SM, Ahmad M, Alnemri ES, and Wang X. Cytochrome C and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade. Cell, 1997, 91: 478-489.

  24. Li P, Yang X, Wasser M, Cai Y, Chia W. Inscuteable and Staufen mediate asymmetric localization and segregation for Prospero RNA during Drosophila neuroblast cell divisions. Cell, 1997, 90: 437-447.