全职PI
黄立豪

青年研究员

  电话:021-31242100

  邮箱:Lihao_huang@fudan.edu.cn

  地址:复旦大学2号交叉学科楼C7013室


个人简介    

2018-2020年 美国圣路易华盛顿大学医学院,免疫及病理学系,讲师

2014-2018年 美国圣路易华盛顿大学医学院,免疫及病理学系,博士后

2007-2013年 美国达特茅斯医学院, 生化系,博士

主要研究方向

研究自体免疫疾病(包括牛皮癣和肠道炎症)免疫应激如何影响脂代谢穏态及动脉粥样硬化、脂肪肝、胰岛素抵抗、糖尿病等代谢疾病进程。利用多领域多学科包括免疫、代谢、淋巴管、脂蛋白和生化技术解决单一学科不容易解决的问题;并整合细胞,小鼠和人类临床转化的方法来实现新药开发以减缓疾病的进程。

荣誉及获奖情况

2019  Kern Lipid Conference Early Career Investigator Award       

2019  Lymphatic Education & Research Network (LE&RN) Travel Award   

2019  American Association of Immunologists Trainee Abstract Award     

2018  Best Poster Award, Lipoprotein Metabolism Gordon Conference, Waterville Resort, NH

2018  American Heart Association Career Development Award           

2018  Travel Award, HDL Workshop in ATVB, San Francisco, CA          

2017  Best Poster Award, Sixth Annual Cardiovascular Research Day, St. Louis, MO      

2017  FASEB MARC Travel Award                   

2017  Lymphatic Education & Research Network (LE&RN) Travel Award     

2016  Best Poster Award, Fifth Annual Cardiovascular Research Day, St. Louis, MO 

2016  Best Travel Award, Lipoprotein Metabolism Gordon Conference, Waterville Resort, NH

2016  Lymphatic Education & Research Network (LE&RN) Travel Award           

2014  Institutional Training Grant (T32), Department of Pathology & Immunology Washington University

2014  Best Poster Award, Lipoprotein Metabolism Gordon Conference, Waterville Resort, NH

代表性成果

  1. Huang L H, Parakkal D, Ciorba M A, Mittendorfer B, Patterson B W, Randolph G J. TNF-targeting Therapeutics selectively increase postprandial chylomicron output and endocrine hormone secretion in subjects with active crohn’s disease.2020 Gastroenterology, 159 (5):1955-1957.

  2. Huang L H, Zinselmeyer B H, Chang C H, Saunders B T, Kim B S, Wiig H, Thomas M J, Sorci-Thomas M G, Randolph G J. Interleukin 17-driven trapping of tissue lipoproteins links immunity to cardiovascular risk in murine psoriasis. Cell Metabolism, 2019, 29, 475-487.

  3. Huang L H, Melton E, Sohn P, Jung D Y, Tsai C Y, Ma T, Sano H, Ha H, Friedline R, Kim J, Usherwood E,Chang C C, Chang T Y. Myeloid-specific ACAT1 gene ablation in mouse reduces adipose tissue macrophage content, improves insulin sensitivity and suppresses diet-induced obesity. American Journal of Physiology-Endocrinology and Metabolism, 2018, 315(3): E340-E356.

  4. Huang L H, Kavine K J, Randolph G J. Cardiac lymphatic Vessels, transport, and healing of the infarcted heart. Journal of the American College of Cardiology-Basic Transl Sci., 2017, 2 (4): 477-483.

  5. Huang L H, Sohn P, Melton E, Jung D Y, Rogers M A, Sano H, Ma T, Fiering S N, Ha H K, Friedline R H,Jason K K, Chang C C, Chang T Y. Myeloid-Acyl-CoA:Cholesterol Acyltransferase 1 deficiency reduces lesion macrophage content and suppresses atherosclerosis progression. Journal of Biological Chemistry, 2016, 291(12): 6232-6244.

  6. Huang L H, Elvinton A, Randolph G. The role of the lymphatic system in cholesterol transport. Fortier in Pharmacology, 2015, 6:182.

  7. Huang L H, Nishi K, Li S, Ho T, Dong R H, Chang C C, Chang T Y. Acyl-Coenzyme A: cholesterol acyltransferase 1: significance of single nucleotide polymorphism at residue 526 and role of proline 347 near the fifth transmembrane domain. FEBS J., 2014, 281(7): 1773-1783. 

  8. Huang L H, Gui J G, Artinger E, Craig R, Berwin B L, Ernst P A, Chang C C, Chang T Y. Acat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33(9): 2081-2087.

  9. Chang, T. Y., Chang, C. C., Huang, L. H., Melton, E., Sohn, P.. Method for selectively inhibiting ACAT1 in the treatment of obesity, metabolic syndrome, and atherosclerosis. Jan. 2, 2018. Application number: 15035780.

  10. Chang, T. Y., Chang, C. C., Huang, L. H.. Methods for treating immunosuppression. Jun. 19, 2014. Application number: 14236629.