青年研究员
黄林章

   青年研究员

   电话:021-31242108

   邮箱:linzhang_huang@fudan.edu.cn

   地址:复旦大学2号交叉学科楼C7019室

 

 


个人简介

2020年 德州大学西南医学中心,讲师,内皮细胞生物学

2019年 德州大学西南医学中心,博士后,血管生物学

2014年 清华大学北京协和医学院,理学博士,心血管药理学

主要研究方向

血管内皮细胞功能与心血管代谢性疾病发病机制的研究。专注于1)机体小分子代谢物与动脉粥样硬化发生或糖代谢紊乱的关系;2)血脂调节;3)基因编辑技术应用于心血管代谢性疾病。

荣誉及获奖情况

  • 2019年 最佳展报奖,海湾血管研究联盟,美国

  • 2016年 博士后基金,美国心脏协会,美国

  • 2016年 青年PI参会奖,美国心脏协会,美国

  • 2016年 博士后参会奖,德州大学西南医学中心,美国

  • 2013年 国家奖学金,清华大学北京协和医学院,中国

代表性成果

  1. Khan H S, Nair V R, Ruhl C R, Alvarez-Arguedas S, Galvan Rendiz J L, Franco L H, Huang L, Shaul P W, Kim J, Xie Y, Mitchell R B, Shiloh M U. Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis. eLife, 2020, 9, e52551. doi:10.7554/eLife.52551.

  2. Cardoso A C, Lam N T, Savla J J, Nakada Y, Pereira A H M, Elnwasany A, Menendez-Montes I, Ensley E L, Bezan Petric U, Sharma G, Sherry A D, Malloy C R, Khemtong C, Kinter M T, Tan W L W, Anene-Nzelu C G, Foo R S-Y, Nguyen N U N, Li S, Ahmed M S, Elhelaly W M, Abdisalaam S, Asaithamby A, Xing C, Kanchwala M, Vale G, Eckert K M, Mitsche M A, McDonald J G, Hill J A, Huang L, Shaul P W, Szweda L I, Sadek H A. Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression. Nature Metabolism, 2020, 2, 167-178. doi:10.1038/s42255-020-0169-x.

  3. Huang L, Chambliss K L, Gao X, Yuhanna I S, Behling-Kelly E, Bergaya S, Ahmed M, Michaely P, Luby-Phelps K, Darehshouri A, Xu L, Fisher E A, Ge W P, Mineo C, Shaul P W. SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis. Nature. 2019, 569, 565-569. doi:10.1038/s41586-019-1140-4.

  4. Ding Y*, Huang L*, Xian X, Yuhanna I S, Wasser C R, Frotscher M, Mineo C, Shaul P W, Herz J. Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation. Sci Signal, 2016, 9, ra29. doi:10.1126/scisignal.aad5578. (*共同第一作者)

  5. Chambliss K L, Barrera J, Umetani M, Umetani J, Kim S H, Madak-Erdogan Z, Huang L, Katzenellenbogen B S, Katzenellenbogen J A, Mineo C, Shaul P W. Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice. Endocrinology, 2016, 157, 3731-3741. doi:10.1210/en.2015-1629.

  6. Huang L, Fan B, Ma A, Shaul P W, Zhu H. Inhibition of ABCA1 protein degradation promotes HDL cholesterol efflux capacity and RCT and reduces atherosclerosis in mice. J Lipid Res, 2015, 56, 986-997. doi:10.1194/jlr.M054742.

  7. Huang L, Zhu H. Novel LDL-oriented pharmacotherapeutical strategies. Pharmacol Res, 2012, 65, 402-410. doi:10.1016/j.phrs.2012.01.007.

  8. Huang L, Zhao H, Huang B, Zheng C, Peng W, Qin L. Acanthopanax senticosus: review of botany, chemistry and pharmacology. Pharmazie, 2011, 66, 83-97.

  9. Huang L, Wei L, Zhao H, Huang B, Rahman K, Qin L. The effect of Eleutheroside E on behavioral alterations in murine sleep deprivation stress model. Eur J Pharmacol, 2011, 658, 150-155. doi:10.1016/j.ejphar.2011.02.036.

  10. Huang L, Huang B, Ye Q, Qin L. Bioactivity-guided fractionation for anti-fatigue property of Acanthopanax senticosus. J Ethnopharmacol, 2011, 133, 213-219. doi:10.1016/j.jep.2010.09.032.

  11. Huang L, Huang B, Liang J, Zheng C, Han T, Zhang Q, Qin L. Antifatigue activity of the liposoluble fraction from Acanthopanax senticosus. Phytother Res, 2011, 25, 940-943. doi:10.1002/ptr.3346.