Tel: 0086-21-31242086
Email: he_huang@fudan.edu.cn
Office Address: Room D7023, Interdisciplinary Building No.2, Fudan University

Personal Profile

He Huang received his Bachelor degree in Wuhan University at 2012, and pursued his Ph.D in the University of Akron, 2017. Being researching on methodologies of metabolomics and lipidomics through the whole period of doctoral time, he joined a mass spec core facility in Isreal Deaconess Medical Center (BIDMC) as a research associate, as well as a postdoc in Harvard Medical School. Two years after postdoctoral training, he came back to China, and joined the IMIB, Fudan University in 2019.  Recently, he is in charge of a metabolomics and lipidomics platform building and management, as well as doing the research on new metabolomics/lipidomics methodologies using in multiple diseases; his research interests are extensively on metabolomics/lipidomics data analyses and metabolic pathway analysis in an efficient manner.

Research Interests
Mass spectrometry – based metabolomic and lipidomic technologies. Application of the metabolomics and lipidomics onto multiple clinical disease treatment, diagnosis and biomarker discovery.

Selected Publications

1. Xiao Guo#, Yuemeng Zhu#, Lu Guo#, Yiwen Qi#, Xiaocheng Liu, Jinhui Wang, Jiangtao Zhang, Linlin Cui, Yueyang Shi, Qichu Wang, Cenxi Liu, Guangxing Lu, Yilian Liu, Tao Li, Shangyu Hong, Yingying Qin, Xuelian Xiong, Hao Wu, Lin Huang, He Huang*, Chao Gu*, Bin Li*, Jin Li*. BCAA insufficiency leads to premature ovarian insufficiency via ceramide-induced elevation of ROS, EMBO Molecular Medicine, 2023, e17450.

2. Liying Zhou#, Qing Li#, Jingshen Xu, Shuaikang Wang, Zhiqiang Song, Xinyi Chen, Yan Ma, Zhiguang Lin, Bobin Chen*, He Huang*. Cerebrospinal Fluid Metabolic Markers Predict Prognosis behavior of Primary CNS Lymphoma with HD-MTX Based Chemotherapeutic Treatment, Neuro-Oncology Advances, 2022, vdac181, doi.org/10.1093/noajnl/vdac181.

3. Zhengqing Song, Shuaikang Wang, Lili Lu, Jingshen Xu, Qiwen Zhou, Weiqi Lu, Hanxing Tong, Yong Zhang, Wenshuai Liu, Zhiming Wang, Wei Li, Yang You, Chenlu Zhang, Xi Guo, Rongkui Luo, Yingyong Hou, Chunmeng Wang, Yuexiang Wang, Lei Sun*, He Huang*, Yuhong Zhou*. Lipidomics and Transcriptomics Differ Liposarcoma Differentiation Characteristics That Can Be Altered by Pentose Phosphate Pathway Intervention, Metabolites, 2022, 12(12), 1227.

4. Yuqin Wang, Xinzhi Li, Cenxi Liu, Liying Zhou, Lei Shi, Zhiguo Zhang, Long Chen, Ming Gao, Lanyue Gao, Yuanyuan Xu, He Huang, Jin Li, and Zheng Chen*. WTAP Regulates Postnatal Development of Brown Adipose Tissue by stabilizing METTL3 in mice, Life Metabolism, 2022, loac028, doi.org/10.1093/lifemeta/loac028.

5. Xiaoyan Wang, Wenwen Kong, Yuan Wang, Jinhui Wang, Luyao Zhong, Kangwen Lao, Xianxin Dong, Dingyu Zhang, He Huang, Beixin Mo, Yu Yu, Guodong Ren. Uridylation and the SKI complex orchestrate the Calvin cycle of photosynthesis through RNA surveillance of TKL1 in Arabidopsis, Proc. Natl. Acad. Sci. USA., 2022, 119(38):e2205842119.

6. Xinzhi Li, Kaixin Ding, Xueying Li, Bingchuan Yuan, Yuqin Wang, Zhicheng Yao, Shuaikang Wang, He Huang, Bolin Xu, Liwei Xie, Tuo Deng, Xiao-wei Chen, Zheng Chen*. Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH). Nature Communications, 2022, 13: 4549.

7. Chuanyou Yi#, Dandan Li#, Xiao Guo#, Jinhui Wang, Cenxi Liu, Guangxing Lu, Yan Sun, He Huang*, Shangyu Hong*, Jin Li*. The Storage Conditionns of High-Fat Diet Are the Key Factors for Diet-Induced Obesity and Liver Damage. Nutrients. 2022, 14(11): 2222.

8. Dandan Li#, Chuanyou Yi#, He Huang, Jin Li*, Shangyu Hong*. Hepatocyte-specific depletion of Nnmt protects mice from non-alcoholic steatohepatitis, Journal of Hepatology, 2022, 77(3):882-884

9. Ziyang Lu#, Fanghe Lin#, Tao Li#, Jinhui Wang, Cenxi Liu, Guangxing Lu, Bin Li, Mingpei Pan, Shaohua Fan, Junqiu Yue, He Huang, Jia Song*, Chao Gu*, Jin Li*. Identification of clinical and molecular features of recurrent serous borderline ovarian tumour, eClinicalMedicine, 2022, doi.org/10.1016/j.eclinm.2022.101377.

10. Fengsheng Li, Jia Song, Yingkun Zhang, Shuaikang Wang, Jinhui Wang, Li Lin, Chaoyong Yang*, Peng Li*, He Huang*. LINT-web: A Web-Based Lipidomic Data Mining Tool Using Intra-Omic Integrative Correlation Strategy, Small Methods, 2021, 2100206.  

11. Qing Cong, Xiao Guo, Shengwei Zhang, Jinhui Wang, Yi Zhu, Lili Wang, Guangxing Lu, Yufeng Zhang, Wei Fu, Liying Zhou, Shuaikang Wang, Cenxi Liu, Jia Song, Chaoyong Yang, Chi Luo, Ting Ni, Long Sui*, He Huang*, Jin Li*. HCV poly U/UC sequence–induced inflammation leads to metabolic disorders in vulvar lichen sclerosis, Life Science Alliance, 2021, 4, e202000906.  

12. He Huang#, Min Yuan, Phillip Seitzer, Susan Ludwigsen, John Asara*. IsoSearch: An Untargeted and Unbiased Metabolite and Lipid Isotopomer Tracing Strategy from HR-LC-MS/MS Datasets, Methods and Protocols, 2020, 3, 54.

13. Min Yuan#, Daniel M. Kremer#, He Huang#, Susanne B. Breitkopf, Issam Ben Sahra, Brendan D. Manning, Costas A. Lyssiotis, John M. Asara. Ex Vivo and In Vivo Stable Isotope Labelling of Central Carbon Metabolism and Related Pathways with analysis by LC-MS/MS, Nature Protocols, 2019 Feb;14(2):313-330. doi: 10.1038/s41596-018-0102-x. (*Co-first author)

14. Wen Cai Zhang, Julie Wells, Kin-Hoe Chow, He Huang, Min Yuan, Tanvi Saxena, Mary Ann Melnick, Katerina Politi, John Asara, Daniel Costa, Carol Bult, Frank Slack. miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma, Nature Metabolism, 2019, April (1) 460–474. doi: 10.1038/s42255-019-0052-9.  

15. He Huang, Alexandra Taraboletti, Leah P. Shriver. Dimethyl fumarate modulates antioxidant and lipid metabolism in oligodendrocytes, Redox Biology, 2015 (5) 169-175, doi:10.1016/j.redox.2015.04.011.