Professor
Tel: 0086-21-31246779
Email:  zhaosm@fudan.edu.cn
Office Address: Room C313, Building of Life Sciences, Fudan University

Personal Profile

Professor Zhao studied in the Chemistry Department of Beijing Normal University from 1984 to 1988. He was engaged in research work at the Chinese Academy of Medical Sciences from 1988 to 1995. In 2000, he obtained a doctorate degree in biochemistry from Purdue University. He worked in P&G and other companies from 2000 to 2005. He has served as an associate researcher/professor and doctoral supervisor of Fudan University from 2006 to present. He is currently the deputy dean of the Institute of Metabolism and Integrative Biology of Fudan University, professor of the Academy of Life Sciences, senior PI of the Institute of Biomedicine, PI of the State Key Laboratory of Genetic Engineering, and chief scientist of National Major Scientific Research Plan for Protein Research. His research work focuses on metabolism and disease, protein post-translational modification and proteomics.

Research Interests

Metabolic regulation mechanism, relationship between metabolic disorders and the occurrence of human diseases, such as the pathogenesis and new intervention methods of human diseases caused by disorders of metabolic enzyme acetylation modification, and the mechanism and intervention methods of tumors caused by disorders of metabolic intermediates.
Lab website: http://metabolism.fudan.edu.cn/

Honors and Awards

• 2018   Leading Talent of National High-Level Talent Special Support Program Ten Thousand People Plan

• 2017   Second Prize of Chinese Medical Science and Technology Award

• 2016   Head of the Innovation Team in Key Areas of the Innovation Talent Promotion Program of the Ministry of Science and Technology

• 2013   First Prize of Natural Science of the Ministry of Education (the first accomplisher)

• 2010   Top Ten Scientific and Technological Progress of Chinese Universities

• 2010   Top Ten Progress of Science in China

代表性成果

1. Mei XY, Qi DS, Zhang T, Zhao Y, Jin L, Hou JL, Wang JH, Lin Y, Xue Y, Zhu PP, Liu ZX, Huang L, Nie J, Si W, Ma JY, Ye JH, Finnell R H, Saiyin H, Wang HY, Zhao JY, Zhao SM, Xu W. Inhibiting MARSs reduces hyperhomocysteinemia‐associated neural tube and congenital heart defects. EMBO Molecular Medicine, 2020, e9469. doi: 10.15252/emmm.201809469.

2. Qu YY, Zhao R, Zhang HL, Zhou Q, Xu FJ, Zhang X, Xu WH, Shao N, Zhou SX, Dai B, Zhu Y, Shi GH, Shen YJ, Zhu YP, Han CT, Chang K, Lin Y, Zang WD, Xu W, Ye DW, Zhao SM, Zhao JY. Inactivation of the AMPK-GATA3-ECHS1 pathway induces fatty acid synthesis that promotes clear cell renal cell carcinoma growth. Cancer Research, 2020, 80(2): 319-333.

3. Yang Li, Cui-Fang Yao, Fu-Jiang Xu, Yuan-Yuan Qu, Jia-Tao Li, Yan Lin, Zhong-Lian Cao, Peng-Cheng Lin, Wei Xu, Shi-Min Zhao*, Jian-Yuan Zhao*. APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression. Nature communications，2019, 10: 2502.

4. Qin Zhang, Baoling Bai, Xinyu Mei, Chunlei Wan, Haiyan Cao, Dan Li, Shan Wang, Min Zhang ,Zhigang Wang , Jianxin Wu, Hongyan Wang, Junsheng Huo, Gangqiang Ding, Jianyuan Zhao, Qiu Xie,Li Wang , Zhiyong Qiu*, Shiming Zhao*, Ting Zhang*. Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects. Nature communications, 2018, 9: 3436.

5. Xia-Di He, Wei Gong, Jia-Nong Zhang, Ji Nie, Cui-Fang Yao, Fu-Shen Guo, Yan Lin, Xiao-Hui Wu, Feng Li, Jie Li, Wei-Cheng Sun, En-Duo Wang, Yan-Peng An, Hui-Ru Tang, Guo-Quan Yan, Peng-Yuan Yang, Yun Wei, Yun-Zi Mao, Peng-Cheng Lin, Jian-Yuan Zhao, Yanhui Xu*, Wei Xu*, Shi-Min Zhao*. Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations. Cell Metabolism, 2018, 27: 1-16.

6. Ya-Kun Zhang, Yuan-Yuan Qu, Yan Lin, Xiao-Hui Wu, Hou-Zao Chen, Xu Wang, Kai-Qiang Zhou,Yun Wei, Fushen Guo, Cui-Fang Yao, Xia-Di He, Li-Xia Liu, Chen Yang, Zong-Yuan Guan, Shi-Dong Wang, Jianyuan Zhao, De-Pei Liu*, Shi-Min Zhao*, Wei Xu*. Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients. Nature communications, 2017, 8: 464.

7. Dan Wang, Feng Wang, Kai-Hu Shi, Hui Tao, Yang Li, Rui Zhao, Han Lu, Wenyuan Duan, Bin Qiao, Shi-Min Zhao*, Hongyan Wang*, Jian-Yuan Zhao*. Lower Circulating Folate Induced by a Fidgetin Intronic Variant Is Associated With Reduced Congenital Heart Disease Susceptibility. Circulation，2017, 135: 1733-1748.

8. Li, F., He, X., Ye, D., Lin, Y., Yu, H., Yao, C., Huang, L., Zhang, J., Wang, F., Xu, S., Wu, X., Liu, L., Yang, C., Shi, J., He, X., Liu, J., Qu, Y., Guo, F., Zhao, J., Xu, W., and Zhao, S*. NADP(+)-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance. Molecular cell, 2015, 60: 661-675.

9. Wenqing Jiang， Shiwen Wang， Mengtao Xiao，Yan Lin， Lisha Zhou, Qunying Lei，Yue Xiong，Kun-Liang Guan, Shimin Zhao*.  Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Molecular Cell, 2011, 43: 1-12.

10. Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim S, Ito S, Yang C, Wang P, Xiao M, Liu L, Jiang W, Liu J, Zhang J, Wang B, Frye S, Zhang Y, Xu Y, Lei Q, Guan K, Zhao S*, Y. Xiong. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α- ketoglutarate-dependent dioxygenases. Cancer Cell, 2011, 19: 17-30.

11. Qijun Wang, Yakun Zhang, Hui Xiong,Yan Lin, Hong Li, Lu Xie, Wei Zhao, YufengYao, Yue Xiong, Kun-Liang Guan, Shimin Zhao*, Guo-Ping Zhao. Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux. Science, 2010, 327: 1004-1008.

12. Shimin Zhao, Wei Xu, Wenqing Jiang, Wei Yu, Yan Lin, Tengfei Zhang,Jun Yao, Pengyuan Yang, Hong Li, Yixue Li, Jiong Shi, Lunxiu Qin, Qunying Lei, Yue Xiong and Kun-Liang Guan. Regulation of Cellular Metabolism by Protein Lysine Acetylation. Science, 2010, 327: 1000-1004.

13. Shimin Zhao, Yan Lin, Wei Xu, Wenqing Jiang, Zhengyu Zha, Pu Wang,Wei Yu,Zhiqiang Li, Lingling Gong, Yingjie Peng, Jianping Ding, Qunying Lei, Kun-Liang Guan, Yue Xiong. Glioma-Derived Mutations in IDH1Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1a. Science, 2009, 324: 261-265.