Professor
Tel: 0086-21-31242088
Email: zhaotj@fudan.edu.cn
Office Address: Room D7021, Interdisciplinary Building No.2, Fudan University

Personal Profile

2019-            Professor, Institute of Metabolism and Integrative Biology, Fudan University

2014-2019    Professor, School of Life Sciences, Xiamen University

2012-2014    Research assistant Professor, UT Southwestern Medical Center, Dallas, Texas

2007-2012    Postdoctoral Fellow, UT Southwestern Medical Center, Dallas, Texas

2007             Ph.D., Biology, Tsinghua University

2002             B.Sc., Biochemistry and Molecular Biology, Shandong University

Research Interests
The focus of Zhao laboratory is to understand the underlying mechanism of these metabolic disorders including obesity, diabetes and fatty liver. They focus on: the physiological function of palmitoyl acyltransferases in regulating metabolism; identification of the key factors in adipogenesis and onset of obesity.

Team Member

Honors and Awards

• 2011  Award for Excellence in Postdoctoral Research, UT Southwestern Medical Center

Selected Publications

1. Wang J#, Li DL#, Zheng LF, Ren SU, Huang ZQ, Tao Y, Liu Z, Shang Y, Pang D, Guo H, Zeng T, Wang H, Huang H, Du X, Ye H, Zhou HM, Li P, Zhao TJ*. (2024) Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration. Dev Cell, 59(3): 384-399.

2. Weng L#, Tang WS#, Wang X#, Gong Y#, Liu C, Hong NN, Tao Y, Li KZ, Liu SN, Jiang W, Li Y, Yao K, Chen L, Huang H, Zhao YZ, Hu ZP, Lu Y, Ye H, Du X, Zhou H*, Li P*, Zhao TJ*. (2024) Surplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy. Nat Commun, 15(1): 133.

3. Wang J, Zheng LF, Ren S, Li DL, Chen C, Sun HH, Liu LY, Guo H*, Zhao TJ*. (2023) ARF6 plays a general role in targeting palmitoylated proteins from the Golgi to the plasma membrane. J Cell Sci, 136(15): jcs261319.

4. Guo H#, Wang J#, Ren S#, Zheng LF#, Zhuang YX, Li DL, Sun HH, Liu LY, Xie C, Wu YY, Wang HR, Deng X, Li P, Zhao TJ* (2022). Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system. Nature Commun, 13: 6004.

5. Wang J, Liang G*, Zhao TJ*. (2022) Adipose triglyceride lipase: The first transacylase for FAHFAs. Life Metabolism, 1: loac016.

6. Wang X#, Liu SY#, Hu GS, Wang HY, Zhang GL, Cen X, Xiang ST, Liu W, Li P, Ye H, Zhao TJ*. (2022) DDB1 prepares brown adipocytes for cold-induced thermogenesis. Life Metabolism, 1, 1: 39-53.

7. Wang X#, Wang HY#, Hu GS#, Tang WS, Weng L, Zhang Y, Guo H, Yao SS, Liu SY, Zhang GL, Han Y, Liu M, Zhang XD, Cen X, Shen HF, Xiao N, Liu CQ, Wang HR, Huang J, Liu W, Li P, Zhao TJ*. (2021) DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Cell Rep, 35: 109281.

8. Tang WS#, Weng L#, Wang X#, Liu CQ#, Hu GS, Yin ST, Tao Y, Hong NN, Guo H, Liu W, Wang HR, Zhao TJ*. (2021) The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity. Cell Rep, 36: 109314.

9. Hao JW#, Wang J#, Guo H#, Zhao YY, Sun HH, Li YF, Lai XY, Zhao N, Wang X, Xie C, Hong L, Huang X, Wang HR, Li CB, Liang B, Chen S*, Zhao TJ*. (2020) CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis. Nat Commun, 11: 4765.

10. Wang J#, Hao JW#, Wang X#, Guo H#, Sun HH, Lai XY, Liu LY, Zhu M, Wang HY, Li YF, Yu LY, Xie C, Wang HR, Mo W, Zhou HM, Chen S, Liang G, Zhao TJ*. (2019) DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Cell Rep, 26: 209-221.