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Representative Publications-2019
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Lv X#, Liu J#, Qin Y, Liu Y, Jin M, Dai J, Chua BT, Yang H, Li P*.Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysisBiochim Biophys Acta Mol Cell Biol Lipidshttps://doi.org/10.1016/j.bbalip.2018.11.001
Li Q, Zhao Q, Zhang J, Zhou L, Zhang W, Chua B, Chen Y, Xu L*, Li P*.The Protein Phosphatase 1 Complex Is a Direct Target of AKT that Links Insulin Signaling to Hepatic Glycogen DepositionCell Rephttps://doi.org/10.1016/j.celrep.2019.08.066
Su L, Zhou L, Chen FJ, Wang H, Qian H, Sheng Y, Zhu Y, Yu H, Gong X, Cai L, Yang X, Xu L, Zhao TJ, Li JZ, Chen X, Li P.Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sitesEMBO Jhttps://doi.org/10.15252/embj.2018100156
Song W, Luo Q, Zhang Y, Zhou L, Liu Y, Ma Z, Guo J, Huang Y, Cheng L, Meng Z, Li Z, Zhang B, Li S, Yee SW, Fan H, Li P, Giacomini KM, Chen L.Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissuePLoS Biolhttps://doi.org/10.1371/journal.pbio.2006571
Jiang TX, Zou JB, Zhu QQ, Liu CH, Wang GF, Du TT, Luo ZY, Guo F, Zhou LM, Liu JJ, Zhang W, Shu YS, Yu L, Li P, Ronai ZA, Matsuzawa SI, Goldberg AL, Qiu XB.SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradationProc Natl Acad Sci U S Ahttps://doi.org/10.1073/pnas.1901039116
Li QQ, Zhao QY, Zhang JY, Zhou LK, Zhang WH, Chua BT, Chen Y, Xu L, Li P.The protein phosphatase 1 complex is a direct target of AKT that links insulin signaling to hepatic glycogen depositionCell Reportshttps://doi.org/10.1016/j.celrep.2019.08.066
Xie Y, Ma A, Wang B, Peng R, Jing Y Wang D, Finnell RH, Qiao B, Wang Y, Wang H, Zheng Y.Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signalingClin Sci (Lond)https://doi.org/10.1042/cs20180842
Wang YM, Zheng YF, Yang SY, Yang ZM, Zhang LN, He YQ, Gong XH, Liu D, Finnell RH, Qiu ZL, Du YS, Wang HY.MicroRNA-197 controls ADAM10 expression to mediate MeCP2's role in the differentiation of neuronal progenitorsCell Death Differhttps://doi.org/10.1038/s41418-018-0257-6
Zhang L, Qin Y, Gong X, Peng R, Cai C, Zheng Y, Du Y, Wang H.A promoter variant in ZNF804A decreasing its expression increases the risk of autism spectrum disorder in the Han Chinese populationTransl Psychiatryhttps://doi.org/10.1038/s41398-019-0369-x
Shi Z, Chen S1, Han X, Peng R, Luo J, Yang L, Zheng Y, Wang H.The rare mutation in the endosome-associated recycling protein gene VPS50 is associated with human neural tube defectsMol Cytogenethttps://doi.org/10.1186/s13039-019-0421-9
Zhang H, Guo Y, Gu H, Wei X, Ma W, Liu D, Yu K, Luo W, Ma L, Liu Y, Xue J, Huang J, Wang Y, Jia S, Dong N, Wang H, Yuan Z. TRIM4 is associated with neural tube defects based on genome-wide DNA methylation analysisClin Epigeneticshttps://doi.org/10.1186/s13148-018-0603-z
Li Y, Yao CF, Xu FJ, Qu YY, Li JT, Lin Y, Cao ZL, Lin PC, Xu W, Zhao SM, Zhao JY.APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progressionNat Communhttps://doi.org/10.1038/s41467-019-10375-x
Liu C, He X, Liu W, Yang S, Wang L, Li W, Wu H, Tang S, Ni X, Wang J, Gao Y, Tian S, Zhang L, Cong J, Zhang Z, Tan Q, Zhang J, Li H, Zhong Y, Lv M, Li J, Jin L, Cao Y*, Zhang F*.Bi-allelic Mutations in TTC29 Cause Male Subfertility with Asthenoteratospermia in Humans and MiceAmerican Journal of Human Geneticshttps://doi.org/10.1016/j.ajhg.2019.10.010
Li W, He X, Yang S, Liu C,Wu H, Liu W, Lv M, Tang D, Tan J, Tang S, Chen Y, Wang J, Zhang Z, Wang H, Jin L, Zhang F, Cao Y.Biallelic mutations of CFAP251 cause sperm flagellar defects and human male infertilityJournal of Human Genetichttps://doi.org/10.1038/s10038-018-0520-1
Wang Q, Li D, Cai B, Chen Q, Li C, Wu Y, Jin L, Wang X, Zhang X, Zhang F.Whole-exome sequencing reveals SALL4 variants in premature ovarian insufficiency: an update on genotype-phenotype correlationsHuman Genetichttps://doi.org/10.1007/s00439-018-1962-4
Liu W, Wu H, Wang L, Yang X, Liu C, He X, Li W, Wang J, Chen Y, Wang H, Gao Y, Tang S, Yang S, Jin L, Zhang F, Cao Y.Homozygous loss-of-function mutations in FSIP2 cause male infertility with asthenoteratospermiaJournal of Genetics and Genomicshttps://doi.org/10.1016/j.jgg.2018.09.006
Yang N, Wu N, Zhang L, Zhao Y, Liu J, Liang X, Ren X, Li W, Chen W, Dong S, Zhao S, Lin J, Xiang H, Xue H,Chen L, Sun H, Zhang J, Shi J, Zhang S, Lu D, Wu X, Jin L, Ding J, Qiu G, Wu Z, Lupski JR, Zhang F.TBX6 compound inheritance leads to congenital vertebral malformations in humans and miceHuman Molecular Geneticshttps://doi.org/10.1093/hmg/ddy358
He X, Li W, Wu H, Lv M, Liu W, Liu C, Zhu F, Li C, Fang Y, Yang C, Cheng H, Zhang J, Tan J, Chen T, Tang D, Song B, Wang X, Zha X, Wang H, Wei Z, Yang S, Saiyin H, Zhou P, Jin L, Wang J, Zhang Z, Zhang F, Cao Y.Novel homozygous CFAP69 mutations in humans and mice cause severe asthenoteratospermia with multiple morphological abnormalities of the sperm flagellaJournal of Medical Geneticshttps://doi.org/10.1136/jmedgenet-2018-105486
Dong S, Wang C, Li X, Shen Q, Fu X, Wu M, Song C, Yang N, Wu Y, Wang H, Jin L, Xu H, Zhang F.Noncoding rare variants of TBX6 in congenital anomalies of the kidney and urinary tractMolecular Genetics and Genomicshttps://doi.org/10.1007/s00438-018-1522-6
Liu W, He X, Yang S, Zouari R, Wang J, Wu H, Kherraf ZE, Liu C, Coutton C, Zhao R, Tang D, Tang S, Lv M, Fang Y, Li W, Li H, Zhao J, Wang X, Zhao S, Zhang J, Arnoult C, Jin L, Zhang Z, Ray PF, Cao Y, Zhang F.Bi-allelic Mutations in TTC21A Induce Asthenoteratospermia in Humans and MiceAmerican Journal of Human Geneticshttps://doi.org/10.1016/j.ajhg.2019.02.020
Wu H, Li W, He X, Liu C, Fang Y, Zhu F, Jiang H, Liu W, Song B, Wang X, Zhou P, Wei Z, Zhang F, Cao Y.Novel CFAP43 and CFAP44 mutations cause male infertility with multiple morphological abnormalities of the sperm flagella (MMAF)Reproductive BioMedicine Onlinehttps://doi.org/10.1016/j.rbmo.2018.12.037
Liu C, Lv M, He X, Zhu Y, Amiri-Yekta A, Li W, Wu H, Kherraf ZE, Liu W, Zhang J, Tan Q, Tang S, Zhu YJ, Zhong Y, Li C, Tian S, Zhang Z, Jin L, Ray P, Zhang F, Cao Y.Homozygous mutations in SPEF2 induce multiple morphological abnormalities of the sperm flagella and male infertilityJournal of Medical Geneticshttps://doi.org/10.1136/jmedgenet-2019-106011
Wang R*, Guo S, Tian H, Huang Y, Yang Q, Zhao K, Kuo CH, Hong S, Chen P*, Liu T*.Hypoxic training in obese mice improves metabolic disorderFront Endocrinolhttps://doi.org/10.3389/fendo.2019.00527
Cappel DA, Deja S, Duarte JAG, Kucejova B, Iñigo M, Fletcher JA, Fu X, Berglund ED, Liu T, Elmquist JK, Hammer S, Mishra P, Browning JD, Burgess SC.Pyruvate-carboxylase-mediated anaplerosis promotes antioxidant capacity by sustaining TCA cycle and redox metabolism in liverCell Metabolisumhttps://doi.org/10.1016/j.cmet.2019.03.014
Cordonier EL, Liu T, Saito K, Chen SS, Xu Y, Fukuda M.Luciferase Reporter Mice for In Vivo Monitoring and Ex Vivo Assessment of Hypothalamic Signaling of Socs3 ExpressionJournal of the Endocrine Societyhttps://doi.org/10.1210/js.2019-00077
Ou Z#, Ma Y#, Sun Y#, Zheng G, Wang S, Xing R, Chen X, Han Y, Wang J, Lu QR*, Zhao TJ*, Chen Y*.A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body MetabolismCell Rephttps://doi.org/10.1016/j.celrep.2019.02.060
Wang J#, Hao JW#, Wang X#, Guo H#, Sun HH, Lai XY, Liu LY, Zhu M, Wang HY, Li YF, Yu LY, Xie C, Wang HR, Mo W, Zhou HM, Chen S, Liang G, Zhao TJ*.DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma MembraneCell Rephttps://doi.org/10.1016/j.celrep.2018.12.022
Wang J, Chua BT, Li P, Chen FJ.Lipid-exchange rate assay for lipid droplet fusion in live cellsBio-protocolhttps://doi.org/10.21769/bioprotoc.3309
Min Yuan*, Daniel M. Kremer*, He Huang*, Susanne B. Breitkopf, Issam Ben Sahra, Brendan D. Manning, Costas A. Lyssiotis, John M. Asara.Ex Vivo and In Vivo Stable Isotope Labelling of Central Carbon Metabolism and Related Pathways with analysis by LC-MS/MSNature Protocolshttps://doi.org/10.1038/s41596-018-0102-x
Zhang WC, Wells JM, Chow KH, Huang H, Yuan M, Saxena T, Melnick MA, Politi K, Asara JM, Costa DB, Bult CJ, Slack FJ.miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinomaNature Metabolismhttps://doi.org/10.1038/s42255-019-0052-9
Cai J, Chen L, Zhang Z, Zhang X, Lu X, Liu W, Shi G, Ge Y, Gao P, Yang Y, Ke A, Xiao L, Dong R, Zhu Y, Yang X, Wang J, Zhu T, Yang D, Huang X, Sui C, Qiu S, Shen F, Sun H, Zhou W, Zhou J, Nie J, Zeng C, Stroup EK, Zhang X, Chiu BC, Lau WY, He C, Wang H, Zhang W, Fan J.Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinomaGuthttps://doi.org/10.1136/gutjnl-2019-318882
Cheng Z, He Z, Cai Y, Zhang C, Fu G, Li H, Sun W, Liu C, Cui X, Ning B, Xiang D, Zhou T, Li X, Xie W*, Wang H*, Ding J*.Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factorsCell Reshttps://doi.org/10.1038/s41422-018-0111-x
Liu J, Jiang J, Mo J, Liu D, Cao D, Wang H, He Y, Wang H*.Global DNA 5-hydroxymethylcytosine and 5-formylcytosine contents are decreased in the early stage of hepatocellular carcinomaHepatologyhttps://doi.org/10.1002/hep.30146
Fu GB, Huang WJ, Zeng M, Zhou X, Wu HP, Liu CC, Wu H, Weng J, Zhang HD, Cai YC, Ashton C, Ding M, Tang D, Zhang BH, Gao Y, Yu WF, Zhai B, He ZY, Wang HY*, Yan HX*.Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogensCell Reshttps://doi.org/10.1038/s41422-018-0103-x
Liu B, Zhang Z, Hu Y, Lu Y, Li D, Liu J, Liao S, Hu M, Wang Y, Zhang D, Hu C, Xiong X, Li XY.Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14Proc Natl Acad Sci U S Ahttps://doi.org/10.1073/pnas.1907288116


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