Tel: 0086-21-31242928
  Email: xingrong_du@fudan.edu.cn
  Office Address: Room C7025, Interdisciplinary Building No.2, Fudan University 

Personal Profile

Dr. Xingrong Du obtained his Ph.D. at Fudan University in 2014 and performed his postdoctoral research in department of Immunology, St. Jude Children’s Research Hospital from 2014-06 to 2021. He joined the Institute of Metabolism & Integrative Biology (IMIB), Fudan University in the end of March , 2021.

Research Interests

We are interested in investigating the roles of cellular metabolism and related signaling in immune cell function, homeostasis and diseases. The main research directions include: 1. Metabolic regulation of DCs and T cells in tumor immunity; 2. Metabolic regulation of T cells and Tregs in immunodeficiency and autoimmunity; 3. Development of novel immune therapy methods of tumor and metabolic diseases.

Selected Publications

1. Guo C, You Z, Shi H, Sun Y, Du X, Palacios G, Guy C, Yuan S, Chapman NM, Lim SA, Sun X, Saravia J, Rankin S, Dhungana Y, Chi H*. SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity. Nature. 2023 Jul 5. doi: 10.1038/s41586-023-06299-8.

2. Du X, Wen J, Wang Y, Karmaus PWF, Khatamian A, Tan H, Li Y, Guy C, Nguyen TM, Dhungana Y, Neale G, Peng J, Yu J, Chi H*. Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells. Nature, 2018, 558(7708): 141-145.

3. Du X,  Zeng H, Liu S, Guy C, Dhungana Y, Neale G, Bergo MO, Chi H*. Mevalonate metabolism–dependent protein geranylgeranylation regulates thymocyte egress. J Exp Med, 2020, 217(2): e20190969.3.

4. Du X, Chapman NM, Chi H*. Emerging roles of cellular metabolism in regulating dendritic cell subsets and function. Frontiers in Cell and Developmental Biology. 2018, 6: 152.4.

5. Du X, Shi H, Li J, Dong Y, Liang J, Ye J, Kong S, Zhang S, Zhong T, Yuan Z, Xu T, Zhuang Y, Zheng B, Geng JG, Tao W*. Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease. J Immunol. 2014,192(4):1525-35.