Tel: 0086-21-31242928
  Email: xingrong_du@fudan.edu.cn
  Office Address: Room C7025, Interdisciplinary Building No.2, Fudan University 

Personal Profile

Dr. Xingrong Du obtained his Ph.D. at Fudan University in 2014 and performed his postdoctoral research in department of Immunology, St. Jude Children’s Research Hospital from 2014-06 to 2021. He joined the Institute of Metabolism & Integrative Biology (IMIB), Fudan University in the end of March , 2021.

Research Interests

We are interested in investigating the roles of cellular metabolism and related signaling in immune cell function, homeostasis and diseases. The main research directions include: 1. Metabolic regulation of DCs and T cells in tumor immunity; 2. Metabolic regulation of T cells and Tregs in immunodeficiency and autoimmunity; 3. Development of novel immune therapy methods of tumor and metabolic diseases.

Selected Publications

1. Amino acid homeostasis by CORVET/HOPS: A metabolic and stress resilience checkpoint for T cells.

   Wang J, Ni Z, Zhang X, He L, Zhang X, Cheng X, Wang H, Sun G, Lu Z, Liu C, Qian H, Lu Y, Liu G, Jia J, Ye J, Huang L, Ye H, Li R, Tao W, Li P, Zhao TJ, Du X.Proc Natl Acad Sci U S A. 2026 Sep;123(35):e2601318123. doi: 10.1073/pnas.2601318123. Epub 2026 Aug 26.

2. Hadhb Deficiency Inhibits Lung Tumorigenesis Via Activating ER Stress.

   Dai W, Xu D, Lei Y, Zhang S, Yu T, Tao W, Chen X, Du X.J Cancer. 2026 May 1;17(5):990-1001. doi: 10.7150/jca.130384. eCollection 2026.

3. Vacuole protein sorting 18 (Vps18) suppresses epithelial growth factor receptor (EGFR) expression and lung tumorigenesis.

   Dai W, Zhang S, Yan S, Zhang H, Zou S, Yu T, Tao W, Ke H, Du X.J Biol Chem. 2025 Aug;301(8):110447. doi: 10.1016/j.jbc.2025.110447. Epub 2025 Jul 2.

4. Ultra-high static magnetic fields cause immunosuppression through disrupting B-cell peripheral differentiation and negatively regulating BCR signaling.

   Gu H, Fu Y, Yu B, Luo L, Kang D, Xie M, Jing Y, Chen Q, Zhang X, Lai J, Guan F, Forsman H, Shi J, Yang L, Lei J, Du X, Zhang X, Liu C. MedComm. 2023 Oct 1;4(5):e379. doi: 10.1002/mco2.379. eCollection 2023 Oct.

5. Mevalonate metabolism–dependent protein geranylgeranylation regulates thymocyte egress.

   Du X, Zeng H, Liu S, Guy C, Dhungana Y, Neale G, Bergo MO, Chi H. J Exp Med. 2020 Feb 3;217(2). pii: e20190969. doi: 10.1084/jem.20190969.

6. Emerging roles of cellular metabolism in regulating dendritic cell subsets and function.

   Du X, Chapman NM, Chi H. Frontiers in Cell and Developmental Biology. 2018 Nov;6:152.

7. Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells.

   Du X, Wen J, Wang Y, Karmaus PWF, Khatamian A, Tan H, Li Y, Guy C, Nguyen TM, Dhungana Y, Neale G, Peng J, Yu J, Chi H. Nature. 2018 Jun;558(7708):141-145. Recommended by F1000Prime. 

8. The non-canonical Hippo/Mst pathway in lymphocyte development and functions.

   Du X, Yu A, Tao W. Acta Biochim Biophys Sin (Shanghai). 2015 Jan;47(1):60-4. doi: 10.1093/abbs/gmu112. Epub 2014 Dec 8. Review.

9. Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis.

   Du X, Dong Y, Shi H, Li J, Kong S, Shi D, Sun LV, Xu T, Deng K, Tao W. PLoS One. 2014 Mar 4;9(3): e90701. 

10. Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease.

    Du X, Shi H, Li J, Dong Y, Liang J, Ye J, Kong S, Zhang S, Zhong T, Yuan Z, Xu T, Zhuang Y, Zheng B, Geng JG, Tao W. J Immunol. 2014 Feb 15;192(4):1525-35.