Office address: Room D7029, Interdisciplinary Building No.2, Jiangwan Campus, Fudan University

Phone: +86 17321005352

Email: shiqing_fdu@fudan.edu.cn

Current Position: Associate Researcher, Institute of Metabolism and Integrative Biology, Fudan University

Education and Professional Experience

July 2023-Present, Associate Researcher, Institute of Metabolism and Integrative Biology, Fudan University

June 2021-June 2023, Postdoctoral Researcher, School of Life Sciences, Fudan University

September 2016-June 2021, PhD, School of Life Sciences, Fudan University

September 2012-June 2016, Bachelor of Science, School of Life Sciences, Jilin University

Research Focus

Post-translational modification of proteins

Research Projects (Principal Investigator)

1. National Natural Science Foundation of China (General Project), Project No.: 32471353 (Ongoing);

2. National Natural Science Foundation of China (Young Scientist Project), Project No.: 82201571, Period: January 2023-December 2024 (Completed);

3. 70th Batch of China Postdoctoral Science Foundation (General Project), Project No.: 2021M700828, Title: Molecular Mechanism of CRL3-IBTK E3 Ubiquitin Ligase Complex-Mediated Non-Degradative Ubiquitination of eIF4A1 and Translation Initiation, Period: December 2021-December 2022 (Completed);

4. 15th Batch of China Postdoctoral Science Foundation (Special Funding in Station), Project No.: 2021M700828, Title: Molecular Mechanism of Natural Compound Sulforaphane in Inhibiting Tumor Immune Escape by Regulating the STAT1-IRF1-PD-L1 Signaling Axis, Period: October 2022-June 2024 (Completed).

Selected Publications (First/Corresponding Author)

1. Kun Gao§, Qing Shi§, Ye Gu§, Wanqi Yang, Yuanlong He, Zeheng Lv, Yan Ding, Wenxin Cao, Chenji Wang, Xiaoping Wan. SPOP mutations promote tumor immune escape in endometrial cancer via the IRF1-PD-L1 axis. Cell Death Differ. 2023 Feb;30(2):475-487.

2. Shi Q§, Jin X, Zhang P, Li Q, He H, Zhao X, Lv Z, Zhao S, Li Y, Gao K, Wang C. SPOP Mutations Promote p62/SQSTM1-dependent Autophagy and Nrf2 Activation in Prostate Cancer. Cell Death Differ. 2022 Jun;29(6):1228-1239.

3. Kai Feng§; Qing Shi§; Yalan Wang; Ke Su; Yan Huang; Yao Li; Chenji Wang; Dongyue Jiao; Yingji Chen; Wanqi Yang; Pingzhao Zhang . SPOP Inhibits BRAF-dependent Tumorigenesis through Promoting Non-degradative Ubiquitination of BRAF. Cell & Biosci. 2022 Dec 30;12(1):211. doi: 10.1186/s13578-022-00950-z. 

4. Ma J§, Shi Q§, Cui G§, Sheng H, Botuyan MV, Zhou Y, Yan Y, He Y, Wang L, Wang Y, Georges Mer, Ye D, Wang C, Huang H. SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition. Nat Comm. 2021 Oct 1;12(1):5779.

5. Jin X§, Qing S§, Li Q, Zhuang H, Shen L, Li J, Qi H, Lin T, Lin Z, Wang J, Cao X, Yang J, Ma Q, Cong L, Xi Y, Fang S, Meng X, Gong Z, Ye M, Wang S, Wang C, Gao K. Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP-HIPK2 axis. Nucleic Acids Res. 2021 Jul 9;49(12):6788-6803.

6. Jin X§, Shi Q§, Li Q, Zhou L, Wang J, Jiang L, Zhao X, Feng K, Lin T, Lin Z, Zhuang H, Yang J, Hu C, Zhang L, Shen L, Lu Y, Zhu J, Wang H, Qi H, Meng X, Xi Y, Pan J, Fang S, Tian H, Zhou C, Zhang P, Gao K, Zhao S, Li Y, Gong Z, Wang C. CRL3-SPOP Ubiquitin Ligase Complex Suppresses the Growth of Diffuse Large B-cell Lymphoma by Negatively Regulating the MyD88/NF-κB Signaling. Leukemia. 2020 May;34(5):1305-1314.

7. Shi Q§, Zhu Y§, Ma J§, Chang K, Ding D, Bai Y, Gao K, Zhang P, Mo R, Feng K, Zhao X, Zhang L, Sun H, Jiao D, Chen Y, Sun Y, Zhao S, Huang H, Li Y, Ren S, Wang C. Prostate Cancer-associated SPOP Mutations Enhance Cancer Cell Survival and Docetaxel Resistance by Upregulating Caprin1-dependent Stress Granule Assembly. Mol Cancer. 2019 Nov 26;18(1):170.

8. Jiantao Xiao§, Qing Shi§, Weiguo Li, Xingyu Mu, Jintao Peng, Mingzi Li, Mulin Chen, Huabing Huang, Chenji Wang, Kun Gao, Jie Fan. ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation. Am J Cancer Res. 2018 Jan 1;8(1):132-143.

Note: § Indicates co-first authorship. All publications are listed in the order of the original document.