Tel: 0086-21-31242915
   Email: yi_xu@fudan.edu.cn
   Office Address: Room C7017, Interdisciplinary Building No.2, Fudan University

Personal Profile

2021.8-present. Institute of Metabolism and Integrative Biology, Fudan University

2021.6-2021.7. Perelman School of Medicine, University of Pennsylvania. Research Associate

2015.4-2021.5. Perelman School of Medicine, University of Pennsylvania. Postdoctoral Fellow

2008.9-2015.1. Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences. Ph.D.

2003.9-2007.6. Pharmaceutical and Life Sciences, Nanjing Tech University. B.S.

Research Interests

Our lab will use advanced technology to investigate how metabolic pathways modulate cell fate determinations, such as self-renewal, differentiation, proliferation, metastasis and drug resistance, etc., in stem cells and cancer cells. Our main research areas are: (1) The physiological functions of chaperone-mediated autophagy (CMA) in stem cells and cancer cells; (2) Metabolic regulation of tumor metastasis and drug resistance.

Honors and Awards

• 2020 NIH NRSA T32 Institutional Training Grant

• 2014 AACR Scholar-In-Training Award

Selected Publications

1. Xu Y*, Yang X*. Autophagy and pluripotency: self-eating your way to eternal youth. Trends in Cell Biology, 2022, 32(10): 868-882. (Notes: selected as cover review article).

2. Zhang Y, Xu Y, Lu W, Li J, Yu S, Brown EJ, Stanger BZ, Rabinowitz JD, Yang X*. G6PD-mediated increase in de novo NADP+ biosynthesis promotes antioxidant defense and tumor metastasis. Science Advances, 2022, 8(29): eabo0404.

3. Zhang Y, Xu Y, Lu W, Ghergurovich JM, Guo L, Blair IA, Rabinowitz JD, Yang X*. Upregulation of antioxidant capacity and nucleotide precursor availability suffices for oncogenic transformation. Cell Metabolism, 2021, 33(1): 94-109. e8.

4. Xu Y, Zhang Y, García-Cañaveras JC, Guo L, Kan M, Yu S, Blair IA, Rabinowitz JD, Yang X*. Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science, 2020, 369(6502): 397-403. (Notes: commented on in this issue).

5. Wang N#, Song L#, Xu Y#, Zhang L, Wu Y, Guo J, Ji W, Li L, Zhao J, Zhang X, Zhan L*. Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling. EbioMedicine, 2019, 47: 65-77.

6. Chang R, Song L, Xu Y, Wu Y, Dai C, Wang X, Sun X, Hou Y, Li W, Zhan X, Zhan L*. Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis. Nature Communications, 2018, 9(1): 1-12.

7. Xu Y, Chang R, Peng Z, Wang Y, Ji W, Guo J, Song L, Dai C, Wei W, Wu Y, Wan X, Shao C, Zhan L*. Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression. Nature Communications, 2015, 6(1): 1-12.