Tel: 0086-21-31242060-8309

 Email: lei_sun@fudan.edu.cn

 Office Address: Room 309, Building of Institute of Developmental Biology and Molecular Medicine, 

 Fudan University

Personal Profile

2019/11-now, Institute of Developmental and Molecular Medicine, Fudan University, Shanghai, China. Young Investigator, PI

2017/7-2019/10, CytoCares (Shanghai) Inc., Shanghai, China. Chief Technology Officer, Co-Founder

2011-2017, Center for Genetics of Host Defense, UT Southwestern Medical Center, Dallas, USA. Instructor

2008-2011, Department of Genetics, The Scripps Research Institute, San Diego, USA. Postdoc

2002-1999, Institute of Developmental and Molecular Medicine, Fudan University, Shanghai, China. Ph.D.

1998-2002, School of Life Science, Fudan University, Shanghai, China. B.S.

Sesearch Interests

Physiology of inflammation; molecular pathology of inflammatory diseases; innovative immunotherapies.

Selected Publications

1. Chen YM#, Zheng YT#, Yu Y#, Wang YZ#, Huang QX#, Qian F#, Sun L#, Song ZG, Chen ZY, Feng JW, An YP, Yang JC, Su ZQ, Sun SY, Dai FH, Chen QS, Lu QW, Li PC, Ling Y, Yang Z, Tang HR, Shi LM, Jin L, Holmes EC, Ding C*, Zhu TY*, Zhang YZ*. Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage. EMBO J, 2020, 39(24): e105896. 

2. Liu MJ, Wang XL, Li Z, Zhang R, Mu J, Jiang YY, Deng Q*, Sun L*. Synergistic effect of ibrutinib and CD19 CAR-T cells on Raji cells in vivo and in vitro. Cancer Sci, 2020, 111(11): 4051-4060.

3. Sun L, Jiang ZF, Acosta-Rodriguez VA, Berger M, Du X, Choi JH, Wang JH, Wang KW, Kilaru GK, Mohawk JA, Quan JX, Scott L, Hildebrand S, Li XH, Tang M, Zhan XM, Murray AR, La Vine D, Moresco EMY, Takahashi JS, Beutler B. HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections. J Exp Med, 2017, 214(11): 3263-3277. 

4. Ye ZS#, Sun L#, Li RB#, Han M, Zhuang Y, Wu X*, Xu T*. Generation of a mouse full-length balancer with versatile cassette-shuttling selection strategy. Int J Biol Sci, 2016, 12(8): 911-6.

5. Brandl K#, Sun L#, Neppl C, Siggs OM, Le Gall SM, Tomisato W, Li XH, Du X, Maennel DN, Blobel CP, Beutler B. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. PNAS, 2010, 107(46): 19967-19972.

6. Sun L, Wu XH*, Han M*, Xu T*, Zhuang Y*. A mitotic recombination system for mouse chromosome 17. PNAS, 2008, 105(11): 4237-4241.