Tel: 0086-21-31242916

Email: chunmei_chang@fudan.edu.cn

Office Address: Room D7015, Interdisciplinary Buiding No.2, Fudan University

Personal Profile

2021.12-present Institute of Metabolism and Integrative Biology, Fudan University. Assistant Professor

2020.10-2021.11 Department of Molecular and Cell Biology, University of California, Berkeley. Assistant Project Scientist

2019.10-2020.10 Department of Molecular and Cell Biology, University of California, Berkeley. Postdoctoral Fellow

2016.10-2019.10 Department of Molecular and Cell Biology, University of California, Berkeley. Tang Distinguished Scholar

2014.7-2016.10 Department of Biochemistry, Zhejiang University School of Medicine. Postdoctoral Fellow

2009.9-2014.6 Department of Biochemistry, Zhejiang University School of Medicine. Ph.D.

2005.9-2009.6 School of Biology and Basic Medical Science, Soochow University. B.S.

Research Interests

Our lab will focus on autophagy and metabolism. We will use a comprehensive approach which combines biochemical, structural, in vitro reconstitution, and cell biological analyses to systematically study: 1) the molecular mechanisms of selective autophagosome formation; 2) the biologic function of selective autophagy in metabolism and their relevant roles in the metabolic disorder disease.

Honors and Awards

• 2016 Tang Distinguished Scholarship, UC Berkeley

• 2013 National Scholarship for Graduate Students, Ministry of Education of China

Selected Publications

1. Strong LM, Chang C, Riley JF, Boecker CA, Flower TG, Buffalo CZ, Ren X, Stavoe AK, Holzbaur EL, Hurley JH*. Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy. Elife, 2021, 10: e70372.

2. Chang C, Jensen LE, Hurley JH*. Autophagosome biogenesis: out of the black box. Nature Cell Biology, 2021, 23(5): 450-456.

3. Chang C, Shi X, Jensen LE, Yokom AL, Fracchiolla D, Martens S, Hurley JH*. Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy. Science Advance, 2021, 7(17): eabg4922.

4. Shi X#, Chang C#, Yokom AL#, Jensen LE, Hurley JH*. The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment. Elife, 2020, 9: e59099.

5. Fracchiolla D#, Chang C#, Hurley JH*, Martens S*. A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy. Journal of Cell Biology, 2020, 219(7): e201912098.

6. Chang C, Young LN, Hurley JH*. The BARA necessities of PtdIns 3-Kinase activation in autophagy. Autophagy, 2019, 15(6): 1122-1123.

7. Chang C#, Young LN#, Morris KL, von Bülow S, Schöneberg J, Yamamoto-Imoto H, Oe Y, Yamamoto K, Nakamura S, Stjepanovic G, Hummer G, Yoshimori T, Hurley JH*. Bidirectional control of autophagy by BECN1 BARA domain dynamics. Molecular Cell, 2019, 73(2): 339-353.

8. Chang C, Su H, Zhang D, Wang Y, Shen Q, Liu B, Huang R, Zhou T, Peng C, Wong C, Shen HM, Lippincott-Schwartz J, Liu W*. AMPK-dependent phosphorylation of GAPDH triggers Sirt1 activation and is necessary for autophagy upon glucose starvation. Molecular Cell, 2015, 60(6): 930-940.

9. Feng W#, Chang C#, Luo D, Su H, Yu S, Hua W, Chen Z, Hu H, Liu W*. Dissection of autophagy in human platelets. Autophagy 2014,10(4): 642-651.

10. Huang R, Xu Y, Qian J, Wan W, Liu B, Chang C, Zhou T, Lippincott-Schwartz J, Liu W*. Deacetylation of nuclear LC3 drives autophagy initiation under starvation. Molecular Cell, 2015, 57(3): 456-466.

11. Liu B, Fang M, Hu Y, Huang B, Li N, Chang C, Huang R, Xu X, Yang Z, Chen Z, Liu W*. Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation. Autophagy, 2014, 10(3): 416-430.

12. Guo Y, Chang C, Huang R, Liu B, Bao L, Liu W*. AP1 is essential for generation of autophagosomes from trans-Golgi network. Journal of Cell Science, 2012, 125(7): 1706-1715.