Tel: 0086-21-31242929

Email: guanlin_wang@fudan.edu.cn

Office Address: Room D7025, Interdisciplinary Buiding No.2, Fudan University

Personal Profile

Dr. Guanlin Wang received her Ph.D. at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences in 2018, where she worked with Prof. John Speakman on the evolution of obesity related genes to test the ‘thrifty gene’ hypothesis. In 2019, She started working as a postdoctoral researcher in Prof. Adam Mead's group at the MRC Weatherall Institute of Molecular Medicine, University of Oxford. Her main research interest is to understand the heterogeneity and molecular drivers of blood malignancies using single cell -omics techniques and identify potential therapeutic targets. She is also developing new computational tools for single cell -omics analyses. Guanlin was appointed as Junior Research Fellow at Wolfson College, University of Oxford in January 2021. In March 2022, she started her group at the Institute of Metabolism and Integrative Biology (IMIB) at Fudan University.

Research Interests

Dr. Wang’s group is mainly focusing on using state-of-the-art techniques including single cell-omics, long reads sequencing and spatial transcriptomics, etc to elucidate the key mechanisms of metabolic syndrome (eg. obesity) and fibrosis. More specifically:

• microevolution of metabolic syndrome related genes and driver mutations in cancer 

• multi-omics analyses of obesity 

• multi-omics analyses of fibrosis

• developing new computational tools to integrate the multi-omics datasets
  

Honors and Awards

• 2021 Oxford Centre for Haematology Pump Priming Awards, University of Oxford

• 2021 Medical Sciences Pump-Priming Fund, University of Oxford

• 2021 Academic fund, Wolfson College, University of Oxford 

• 2020 BRC Training Grant, University of Oxford

• 2017 Dean Award, Chinese Academy of Sciences

• 2016 National Scholarship, Ministry of Education of the People’s Republic of China

• 2016 New Investigator Award finalist fellowship (5 finalists all over the world), International Congress for Obesity (ICO) and World Obesity Federation

Selected Publications

1. Wang G, Speakman JR*. Analysis of positive selection at single nucleotide polymorphisms associated with body mass index does not support the “thrifty gene” hypothesis. Cell Metabolism, 2016, 24(4), 531-541. (F1000 Prime recommended)

2. Wang G, Li B, Zhang X, Niu C, Li J, Li L, Speakman JR*. No seasonal variation in physical activity of Han Chinese living in Beijing. International Journal of Behavioral Nutrition and Physical Activity, 2017, 14(1), 48. 

3. Psaila B#,*, Wang G#, Rodriguez-Meira A, Li R, Heuston EF, Murphy L, Yee D, Hitchcock I, Sousos N, O'Sullivan J, Anderson S, Senis Y, Weinberg O, Calicchio M, NIH Intramural Sequencing Center, Iskander D, Royston D, Milojkovic D, Roberts I, Bodine D, Thongjuea S *, Mead A*. Single-cell analyses reveal megakaryocyte-biased hematopoiesis in myelofibrosis and identify mutant clone-specific targets. Molecular Cell, 2020, 78(3), 477-492. (#co-first author) (Faculty Opinions recommended)

4. Roy A#, *, Wang G#, Iskander D, O'Byrne S, Elliott N, O'Sullivan J, Buck G, Heuston EF, Wen WX, Rodriguez-Meira A, Hua P, Karadimitris A, Mead A, Bodine D, Roberts I, Psaila B*, Thongjuea S*. Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development. Cell Reports, 2021, 36(11), 109698. (#co-first author)

5. Iskander D, Wang G, Heuston EF, Christodoulidou C, Psaila B, Ponnusamy K, Ren H, Mokhtari Z, Robinson M, Chaidos A, Trivedi P, Trasanidis N, Katsarou A, Szydlo R, Palii C, Zaidi M, Al-Oqaily Q, Caputo V, Roy A, Harrington Y, Karnik L, Naresh K, Mead A, Thongjuea S, Brand M, Fuente J, Bodine D, Roberts I, Karadimitris A*. Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia. Science Translational Medicine, 2021, 13(610), eabf0113.

6. COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium, A blood atlas of COVID-19 defines hallmarks of disease severity and specificity, 2022, Cell, 185, 916–938.

7. Lin X, Wang G. Development of a RNAi-based release of insects carrying a dominant lethal (RIDL) system in Drosophila melanogaster. Science Bulletin, 2015, 60(3), 356-362.

8. Wu Y, Green CL, Wang G, Yang D, Li L, Li B, Wang L, Li M, Li J, Xu Y, Zhang X, Niu C, Hu S, Togo J, Mazidi M, Derous D, Douglas A, Speakman JR*. Effects of dietary macronutrients on the hematic transcriptome and serum metabolome in mice. Ageing Cell, 2022, e13585.

9. Li B#, Li L#, Li M#, Lam SM#, Wang G, Wu Y, Zhang H, Niu C, Zhang X, Liu X, Hambly C, Jin W, Shui G, Speakman JR*. Microbiota depletion impairs thermogenesis of brown adipose tissue and browning of white adipose tissue. Cell Reports, 2019, 26(10), 2720-2737.

10. Hu S#, Wang L#, Yang D#, Li L#, Togo J#, Wu Y#, Liu Q, Li B, Li M, Wang G, Zhang X, Niu C, Li J, Xu Y, Couper E, Davis A, Mazidi M, Douglas A, Luo Li, Wang S, Douglas A, Speakman JR*. Dietary fat, but not protein or carbohydrate, regulates energy intake and causes adiposity in mice. Cell Metabolism, 2018, 28(3), 415-431.