Insulin resistance is the core mechanism of type 2 diabetes, and the liver is the main target organ for insulin action.Recently, Professor Xiaoying Li from Fudan University led a team to publish important research results online in The Journal of Clinical Investigation (JCI), an internationally renowned medical journal. The study revealed the pathogenic role of the precursor of steroid hormone 17-hydroxyprogesterone (17OHP) in insulin resistance and type 2 diabetes.