Tel: 0086-21-31242108

Email: linzhang_huang@fudan.edu.cn

Office Adrress: Room C7019, Interdisciplinary Building No.2, Fudan University

Personal Profile

2020 Faculty (Endothelial biology) in the Department of Pediatrics, UT Southwestern Medical Center at Dallas, USA
2019 Postdoctoral Fellow (Cardiovascular Biology), UT Southwestern Medical Center, USA
2014 Peking Union Medical College, Tsinghua University, China, Graduate Degree: Ph.D. (Cardiovascular Pharmacology)

Research Interests

Our laboratory is interested in the function of vascular endothelial cells in cardiometabolic diseases. We focus on the circulating or tissue metabolites contributing to the development of atherosclerosis and glucose metabolism during the metabolic disorders. We are also interested in defining novel pathway lowering lipids such as triglycerides and cholesterol. A final area of research interest focuses on novel gene manipulating tools to correct inherited cardiometabolic diseases. Research efforts in each project span from wet-to-dry, including molecular, genetic, cellular, animal model, human sample analysis and bioinformatics.

Honors and Awards

• 2019 Best Poster Award. Gulf Coast Vascular Research Consortium. USA

• 2016 Postdoctoral Fellowship. American Heart Association. USA

• 2016 Young Investigator Travel Award. American Heart Association. USA

• 2016 Postdoctoral Spring Travel Award. UT Southwestern. USA

• 2013 National Scholarship. Peking Union Medical College, Tsinghua Univ. China

 Selected Publications

1. Yaxin Niu*, Shengmin Hu*, Yanfeng Zhang, Jinbao Yang, Jiarui Zhang, Ruiping He, Li Chen, Lin Xu, Hongfang Zhao, Bing Gan, Ruobing Ren, Ruth JF Loos, Haobin Ye, Xingrong Du, Tongjin Zhao, Peng Li, Antonio Vidal-Puig, Linzhang Huang#. Lactate-activated GPR81/FARP1 signaling drives insulin-independent glucose uptake and metabolic control. Cell Research, 2026, 36(2):137-151. PMID: 41530347.

2. Shanshan Wang, Jiarui Zhang, Weiyi Wang, Dongyu Huang, Xin Zeng, Xiaoqu Chen, Xingang Zhang, Hui Qian, Linghua Meng#, Linzhang Huang#, Chengbin Yang#, Shengming Ma#. Chem-Stamp Empowered Discovery of a Novel ATRA-Based LDLR Up-Regulator for the Treatment of Atherosclerosis. J Med Chem. 2026, 69(15):18431-18449. PMID: 42479778. (# co-corresponding author)

3. Ruixin Liu*, Fangyuan Chang*, Yue Sun, Haibo Yu, Jingyu Guo, Yaxin Niu, Jiting Xiao, Meixi Quan, Huizhen Lv, Chen Chen, Zhaocai Zhou, Linzhang Huang#, Ding Ai#. Flow-responsive protein phosphatase 2A-striatin 3 holoenzyme promotes endothelial low-density lipoprotein transcytosis and atherogenesis. Signal Transduction and Targeted Therapy, 2026. (accepted) DOI: 10.1038/s41392-026-03084-7. (#co-corresponding author).

4. Jiarui Zhang*, Zehui Cao*, Jinbao Yang*, Kuo Zhu, Shuai Liu, Weijie Liu, Jin Lu, Hongfang Zhao, Wei Dai, Chunmei Chang, Haobin Ye, Xingrong Du, Qi Wang, Binghua Jiang, Sijia Wang, Li Jin, Tongjin Zhao, Peng Li, Antonio Vidal-Puig, Yuanting Zheng, Leming Shi, Linzhang Huang#. Glycine–GLRA1–calmodulin signaling regulates endoplasmic reticulum calcium to sustain insulin secretion and β-cell function. Life Metabolism, 2025, 5(2):loaf044. PMID: 42037784.

5. Liming Yu, Lin Xu, Haiyan Chu, Jun Peng, Anastasia Sacharidou, Hsi-hsien Hsieh, Ada Weinstock, Sohaib Khan, Liquan Ma, Jose Gabriel Barcia Duran, Jeffrey McDonald, Erik Nelson, Sunghee Park, Donald McDonnell, Kathryn Moore, Lily Huang, Edward Fisher, Chieko Mineo, Linzhang Huang#, Philip Shaul#. Macrophage-to-endothelial Cell Crosstalk by the Cholesterol Metabolite 27HC Promotes Atherosclerosis in Male Mice. Nature Communications, 2023, 14:4101. PMID: 37491347. (# co-corresponding author)

6. Linzhang Huang, Ken L. Chambliss, Xiaofei Gao, Ivan Yuhanna, Erica Behling-Kelly, Sonia Bergaya, Mohamed Ahmed, Peter Michaely, Kate Luby-Phelps, Anza Darehshouri, Lin Xu, Edward A. Fisher, Woo-ping Ge, Chieko Mineo#, Philip W. Shaul#. SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis. Nature, 2019, 569(7757): 565-569. PMID: 31019307.

7. Yinyuan Ding*, Linzhang Huang*, Xunde Xian*, Ivan S Yuhanna, Catherine R Wasser, Michael Frotscher, Chieko Mineo, Philip W Shaul#, Joachim Herz#. Loss of Reelin protects against atherosclerosis by reducing leukocyte–endothelial cell adhesion and lesion macrophage accumulation. Science Signaling, 2016, 9(419): pp.ra29. PMID: 26980442. (*co-first author)

8. Linzhang Huang, Baoyan Fan, Ang Ma, Philip Shaul, Haibo Zhu#. Inhibition of ABCA1 protein degradation promotes HDL cholesterol efflux capacity and RCT and reduces atherosclerosis in mice. Journal of Lipid Research, 2015, 56(5):986-997. PMID: 25761370.