Tel: 0086-21-31242108

Email: linzhang_huang@fudan.edu.cn

Office Adrress: Room C7019, Interdisciplinary Building No.2, Fudan University

Personal Profile

2020 Faculty (Endothelial biology) in the Department of Pediatrics, UT Southwestern Medical Center at Dallas, USA
2019 Postdoctoral Fellow (Cardiovascular Biology), UT Southwestern Medical Center, USA
2014 Peking Union Medical College, Tsinghua University, China, Graduate Degree: Ph.D. (Cardiovascular Pharmacology)

Research Interests

Our laboratory is interested in the function of vascular endothelial cells in cardiometabolic diseases. We focus on the circulating or tissue metabolites contributing to the development of atherosclerosis and glucose metabolism during the metabolic disorders. We are also interested in defining novel pathway lowering lipids such as triglycerides and cholesterol. A final area of research interest focuses on novel gene manipulating tools to correct inherited cardiometabolic diseases. Research efforts in each project span from wet-to-dry, including molecular, genetic, cellular, animal model, human sample analysis and bioinformatics.

Honors and Awards

• 2019 Best Poster Award. Gulf Coast Vascular Research Consortium. USA

• 2016 Postdoctoral Fellowship. American Heart Association. USA

• 2016 Young Investigator Travel Award. American Heart Association. USA

• 2016 Postdoctoral Spring Travel Award. UT Southwestern. USA

• 2013 National Scholarship. Peking Union Medical College, Tsinghua Univ. China

 Selected Publications

1. Liming Yu, Lin Xu, Haiyan Chu, Jun Peng, Anastasia Sacharidou, Hsi-hsien Hsieh, Ada Weinstock, Sohaib Khan, Liquan Ma, Jose Gabriel Barcia Duran, Jeffrey McDonald, Erik Nelson, Sunghee Park, Donald McDonnell, Kathryn Moore, Lily Huang, Edward Fisher, Chieko Mineo, Linzhang Huang# and Philip Shaul#. Macrophage-to-endothelial Cell Crosstalk by the Cholesterol Metabolite 27HC Promotes Atherosclerosis in Male Mice. Nature Communications, 2023 (online 7/25/23) (共同通讯)

2. Huang L, Chambliss K L, Gao X, Yuhanna I S, Behling-Kelly E, Bergaya S, Ahmed M, Michaely P, Luby-Phelps K, Darehshouri A, Xu L, Fisher E A, Ge W P, Mineo C, Shaul P W. SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis. Nature, 2019, 569, 565-569. doi:10.1038/s41586-019-1140-4.
   

3. Ding Y*, Huang L*, Xian X*, Yuhanna I S, Wasser C R, Frotscher M, Mineo C, Shaul P W, Herz J. Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation. Sci Signal, 2016, 9, ra29. doi:10.1126/scisignal.aad5578. (*Co-first author)
   

4. Huang L, Fan B, Ma A, Shaul P W, Zhu H. Inhibition of ABCA1 protein degradation promotes HDL cholesterol efflux capacity and RCT and reduces atherosclerosis in mice. J Lipid Res, 2015, 56, 986-997. doi:10.1194/jlr.M054742.