Tel: 0086-21-31242083
Email: yang_hui@fudan.edu.cn
Office Address: Room D7011, Interdisciplinary Building No.2, Fudan University

Personal Profile

Dr. Hui Yang obtained Ph.D in Shanghai Institute of Biochemistry and Cell Biology (SIBCB), Chinese Academy of Sciences in November 2014 with a doctorate in biochemistry and molecular biology. During December 2014 to April 2017, Dr. Yang finished her Postdoctoral fellowship research work in SIBCB. She joined Fudan University in May 2017 as a young associate investigator.

Research Interests

Dr. Yang is mainly interested in the study of the function and mechanism of lipid metabolism related genes，including the functional study of new genes related to hyperlipidemia and the mechanism of ubiquitination mediated degradation of CIDE family proteins.

Honors and Awards

• Sponsored by Shanghai Sailing Program, 2019

• First-class funding from the China Postdoctoral Science Foundation, 2016

• Doctoral National Scholarship, 2014

Selected Publications

1. Yang H#, Yue HW#, He WT, Hong JY, Jiang LL, Hu HY. PolyQ-expanded huntingtin and ataxin-3 sequester ubiquitin adaptors hHR23B and UBQLN2 into aggregates via conjugated ubiquitin. FASEB J, 2018, 32(6):2923-2933. (# Co-first author)

2. Yang H, Hu HY. Sequestration of cellular interacting partners by protein aggregates: implication in a loss-of-function pathology. FEBS J, 2016, 283, 3705-3717.

3. Yang H, Liu S, He WT, Zhao J, Jiang LL, Hu HY. Aggregation of polyglutamine-expanded ataxin-7 protein specifically sequesters ubiquitin-specific protease 22 and deteriorates its deubiquitinating function in the Spt-Ada-Gcn5-Acetyltransferase (SAGA) complex. J Biol Chem, 2015, 290(36): 21996-22004.

4. Yang H, Li JJ, Liu S, Zhao J, Jiang YJ, Song AX, Hu HY. Aggregation of polyglutamine-expanded ataxin-3 sequesters its specific interacting partners into inclusions: Implication in a loss-of-function pathology. Scientific Reports. 2014, 4: 6410.

5. Song AX#, Yang H#, Gao YG, Zhou CJ, Zhang YH, Hu HY. A Ubiquitin Shuttle DC-UbP/UBTD2 Reconciles Protein Ubiquitination and Deubiquitination via Linking UbE1 and USP5 Enzymes. PLoS ONE, 2014, 9(9):e107509.  (# Co-first author)

6. Kuang SY#, Zheng J#, Yang H, Li SH, Duan SY, Shen YF, Ji C, Gan JH, Xu WX, Li J. Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis. Proc Natl Acad Sci USA, 2017, 114(40):10642-10647.

7. Gao YG, Yang H, Zhao J, Jiang YJ, Hu HY. Autoinhibitory Structure of the WW Domain of HYPB/SETD2 Regulates Its Interaction with the Proline-Rich Region of Huntingtin. Structure, 2014, 22(3): 378-386.

8. Liu S, Yang H, Zhao J, Zhang YH, Song AX, Hu HY. NEDD8 Ultimate Buster-1 Long (NUB1L) Promotes Transfer of NEDD8 to Proteasome for Degradation through the P97UFD1/NPL4 Complex. J Biol Chem, 2013, 288(43):31339-31349.