Office Address: Room D7013, Interdisciplinary Building No.2, Fudan University
Using the African clawed frog as a model animal, screen a class of important epigenetic regulatory factors-histone lysine demethylase family proteins, and participate in the regulation of core signaling pathways during early embryo development.
Using CRISPR / Cas9 technology combined with haploid embryonic stem cell technology, quickly establish a single gene mutation and multi-gene mutation mouse model that simulates human neural tube defects. The use of mouse models enables efficient screening of the pathogenicity of human-derived gene mutations, and further elucidates its pathogenic mechanism.
2017 Outstanding Paper Award of the 16th Chinese Medical Association Medical Genetics Conference
2015 Nanjing University Outstanding Graduates (PhD) (Top 10%)
Lei Lu#, Yan Gao#, Zan Zhang, Qing Cao, Xuena Zhang, Jianghuan Zou, Ying Cao*. Kdm2a/b Lysine Demethylases Regulate Canonical Wnt Signaling by Modulating the Stability of Nuclear β-Catenin. Developmental Cell, 2015, 33(6): 660-674.
Gao YQ#, Chen Xin#, Wang Pei, Lu Lei, Zhao Wei, Chen Chen, Chen CP, Tao Tao, Sun Jie, Zheng YY, Du Jie, Li CJ, Gan ZJ, Gao Xiang, Chen HQ, Zhu MS*. Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance. PNAS, 2015, 44: 13627-13632.
Cao Qing#, Zhang XN#, Lu Lei, Yang LN, Gao JM, Gao Yan, Ma HH, Cao Ying*. Klf4 is required forgerm-layer differentiation and body axis patterning during Xenopus embryogenesis. Development, 2012, 139: 3950-3961.
Li Qing#, Li Yanjing#, Yang Sunming, Huang Shuo, Yan Meng, Ding Yifu, Tang Wei, Lou Xiwen, Yin Qi, Sun Zhanfei, Lu Lei, Shi Huijuan, Wang Hongyan, Chen Yong*, Li jinsong*. CRISPR-Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development. Nature Cell Biology, 2018, 20(11): 1315-1325.
Wang Xiukun#, Kang Junyan#, Wei Leixin#, Yang Xiaogan#, Sun Hongduo, Yang Sunming, Lu Lei, Yan Meng, Bai Meizhu, Chen Yanyan, Long Juanjuan, Li Na, Li Dangsheng, Huang Jing, Lei Ming, Shao Zhen, Yuan Wen, Zuo Erwei*, Lu Kehuan*, Liu Mofang*, Li Jinsong*. PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis. Development, 2019, 146(7): 1-11.