Tel: 0086-21-31242085
Email: derrick_chen@fudan.edu.cn

Office Address: Room D7013, Interdisciplinary Building No.2, Fudan University

Personal Profile

Dr. Chen obtained his B.S. degree in Department of Electrophysics, National Chiao Tung University, Taiwan (June 2004), and his Ph.D degree in Institute of Electro-Optical Engineering, National Chiao Tung University, Taiwan (September 2012). During June 2010-May 2012, Dr. Chen went in for a part-time Ph.D research assistant work in Institute of Molecular and Genomic Medicine, National Health Research Institutes ( NHRI), Taiwan. During Aril-May 2012, Dr. Chen visited the lab of Professor Xiaohang Yang in College of Life Sciences, Zhejiang University. During September 2013-June 2018, Dr. Chen finished his Postdoctoral fellowship research work. In July 2018, Dr. Chen was engaged as Younger Investigator in Institute of Metabolism and Integrative Biology, Fudan University.

Research Interests

Dr. Chen is mainly interested in the study of molecular mechanism in lipid droplet biology and lipid homeostasis. Utilizing quantitative bio-imaging, biophysical modeling assays, and classical molecular and biochemical methods, we attempt to address the causes of dysfunctional lipid metabolism and pathophysiological phenotypes in metabolic diseases, such as obesity, diabetes, and fatty liver.

Honors and Awards

• Excellent Poster Award in 2016 LBSC Conference, July 2016

• Cold Spring Harbor Asia Fellowship Award, June 2015

• CLS (Center of Life Science) Postdoctoral Fellowship, Oct. 2013

• Honor member of the Phi Tau Phi Scholastic Honor Society, June 2013

Selected Publications

1. Kevin Qian, Marcus J. Tol, Jin Wu, Lauren F. Uchiyama, Xu Xiao, Liujuan Cui, Alexander H. Bedard, Thomas A. Weston, Pradeep S. Rajendran, Laurent Vergnes, Yuta Shimanaka, Yesheng Yin, Yasaman Jami-Alahmadi, Whitaker Cohn, Bryce T. Bajar, Chia-Ho Lin, Benita Jin, Laura A. DeNardo, Douglas L. Black, Julian P. Whitelegge, James A. Wohlschlegel, Karen Reue, Kalyanam Shivkumar, Feng-Jung Chen, Stephen G. Young, Peng Li, and Peter Tontonoz. CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization. Nature, 2023, 613:160-168.

2. Guoqing Tang†, Chengxin Ma†, Liangkui Li, Shaoyan Zhang, Fengsheng Li, Jin Wu, Yesheng Yin, Qing Zhu, Yan Liang, Ru Wang, He Huang, Tong-Jin Zhao, Hongyuan Yang, Peng Li, and Feng-Jung Chen. PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure. SCIENCE CHINA-Life Sciences, 2022, 65:2287-2300. (†Co-first authors)

3. Xuchao Lyu†, Jia Wang†, Jianqin Wang†, Ye-Sheng Yin, Yun Zhu, Lin-Lin Li, Shuangru Huang, Shuang Peng, Boxin Xue, Rongyu Liao, Shi-Qiang Wang, Mian Long, Thorsten Wohland, Boon Tin Chua, Yujie Sun, Pilong Li, Xiao-Wei Chen, Li Xu, Feng-Jung Chen*, and Peng Li*. A gel-like condensation of Cidec generates lipid-permeable plates for lipid droplet fusion. Developmental Cell, 2021, 56:2592-2606. (†Co-first authors; *Co-corresponding authors)

4. Feng-Jung Chen, Yesheng Yin, Boon Tin Chua, and Peng Li. CIDE family proteins control lipid homeostasis and the development of metabolic diseases. Traffic, 2020, 21(1): 94-105. (Invited review article)

5. Jia Wang, Boon Tin Chua, Peng Li, and Feng-Jung Chen. Lipid-exchange rate assay for lipid droplet fusion in live cells. Bio-protocol, 2019, 9: e3309.

6. Jia Wang, Chengsong Yan, Chenqi Xu, Boon Tin Chua, Peng Li*, and Feng-Jung Chen*. Polybasic RKKR motif in the linker region of lipid droplet (LD)-associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids. The Journal of. Biological Chemistry, 2018, 293(50): 19330–19343. (*Co-corresponding authors)

7. Feng-Jung Chen, Jhih-Sian Wong, Ken Y. Hsu, and Long Hsu. Thermally activated state transition technique for femto-Newton-level force measurement. Optics Letters, 2012, 37(9): 1469–1471.

8. Chia-Han Chan†, Feng-Jung Chen†, Ying-Jung Huang, Hsin-Yu Chen, Kuo-Liang Liu, Zhe-Chong Wang, Hwei-Ling Peng, Tri-Rung Yew, Cheng-Hsien Liu, Gunn-Guang Liou, Ken Y. Hsu, Hwan-You Chang, and Long Hsu. Identification of protein domains affecting mechanical properties of Klebsiella pneumoniae type 3 fimbriae. Langmuir, 2012, 28(19): 7428–7435. (†Co-first authors)

9. Feng-Jung Chen†, Chia-Han Chan†, Ying-Jung Huang, Kuo-Liang Liu, Hwei-Ling Peng, Hwan-You Chang, Gunn-Guang Liou, Tri-Rung Yew, Cheng-Hsien Liu, Ken Y. Hsu, and Long Hsu. Structural and mechanical properties of Klebsiella pneumonia type 3 fimbriae. Journal of Bacteriology, 2011, 193(7): 1718–1725. (†Co-first authors)

10. 徐琅、刘承贤、杨裕雄、陈丰荣、王威、周忠诚，振荡器、质量测量系统以及质量量测方法，2011，专利号：CN101576404B（中华人民共和国发明专利）