Feng-Jung Chen, Institute of Metabolism and Integrative Biology, Fudan University

Investigator, Ph.D.

Tel: 021-31242085

Email: derrick_chen@fudan.edu.cn

Office Address: Room D7013, Interdisciplinary Building No.2, Fudan University 

Personal Profile

Dr. Chen obtained his B.S. degree in Department of Electrophysics, National Chiao Tung University, Taiwan (June 2004), and his Ph.D degree in Institute of Electro-Optical Engineering, National Chiao Tung University, Taiwan (September 2012). During June 2010-May 2012, Dr. Chen went in for a part-time Ph.D research assistant work in Institute of Molecular and Genomic Medicine, National Health Research Institutes ( NHRI), Taiwan. During Aril-May 2012, Dr. Chen visited the lab of Professor Xiaohang Yang in College of Life Sciences, Zhejiang University. During September 2013-June 2018, Dr. Chen finished his Postdoctoral fellowship research work. In July 2018, Dr. Chen was engaged as Younger Investigator in Institute of Metabolism and Integrative Biology (IMIB), Fudan University. Since December 2024, Dr. Chen has been employed as Investigator in IMIB, Fudan University.

Research Interests

Dr. Chen is mainly interested in the study of molecular mechanism in lipid droplet biology and lipid homeostasis. Utilizing quantitative bio-imaging, biophysical modeling assays, artificial intelligence methods, and classical molecular and biochemical methods, we attempt to address the causes of dysfunctional lipid metabolism and pathophysiological phenotypes in metabolic diseases, such as obesity, diabetes, and fatty liver. 

Honors and Awards

• Fudan University's 11th Good Mentor in the Heart of Graduate Students Nomination Award, April 2024

• CLS (Center of Life Science) Postdoctoral Fellowship, Oct. 2013

• Honor member of the Phi Tau Phi Scholastic Honor Society, June 2013

Selected Publications

1. Chengxin Ma, Yan Liang, Xinmeng Che, Yuqi Li, Jin Wu, Li Xu, Hongyuan Yang, Tong-Jin Zhao, Feng-Jung Chen*, and Peng Li*. Dissection of surface area-dependent lipolysis at a single organelle level. Cell Reports, 2025, 8:116100. (*Co-corresponding authors)

2. Chengxin Ma, Xinmeng Che, Yan Liang, Jiacheng Li, Kuan Yu, Tong-Jin Zhao, Peng Li*, and Feng-Jung Chen*. HSP90 deficiency promotes cholesteryl ester accumulation in lipid droplets via endocytosis of low-density lipoprotein. Communications Biology, 2025, 8:1169. (*Co-corresponding authors)

3. Jin Wu†, Yudi Zhao†, Liwen Qiu, Qiaoli Chen, Xiaowei Wang, Jingwen Gu, Hong-Yu Wang, Yang Liu, Xiaoqin Wu, Shuai Chen, Feng-Jung Chen*, Mingming Gao*, and Hongyuan Yang*. ORP2 regulates free cholesterol accumulation in hepatocytes during MASH. Hepatology Communications, 2025, 9:e0737. (†Co-first authors; *Co-corresponding authors)

4. Jin Wu, Mingming Gao, Xiaoqin Wu, Yang Liu, Taiping Zhang, Yan Liang, Haixia Yang, Chengxin Ma, Youpi Ye, Chunmei Chang, Peng Li*,Feng-Jung Chen*, and Hongyuan Yang*. PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis. Proceedings of the National Academy of Sciences of the United States of America, 2025, 122:e2504219122. (*Co-corresponding authors)

5. Yiming Lu†, Zanzan Zhu†, Jianqin Wang, Xuchao Lyu, Peng Li*, and Feng-Jung Chen*. Protocol for in vitro phase separation of N-terminus of CIDEC proteins. STAR Protocols, 2025, 6:103779. (†Co-first authors; *Co-corresponding authors)

6. Yan Liang, Zanzan Zhu, Yiming Lu, Chengxin Ma, Jiacheng Li, Kuan Yu, Jin Wu, Xinmeng Che, Xu Liu, Xiaoxiao Huang, Peng Li, and Feng-Jung Chen. Cytoskeleton regulates lipid droplet fusion and lipid storage by controlling lipid droplet movement. BBA - Molecular and Cell Biology of Lipids, 2025, 1870:159610.

7. Guoqing Tang†, Chengxin Ma†, Liangkui Li, Shaoyan Zhang, Fengsheng Li, Jin Wu, Yesheng Yin, Qing Zhu, Yan Liang, Ru Wang, He Huang, Tong-Jin Zhao, Hongyuan Yang, Peng Li, and Feng-Jung Chen. PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure. SCIENCE CHINA-Life Sciences, 2022,65:2287-2300. (†Co-first authors)

8. Xuchao Lyu†, Jia Wang†, Jianqin Wang†, Ye-Sheng Yin, Yun Zhu, Lin-Lin Li, Shuangru Huang, Shuang Peng, Boxin Xue, Rongyu Liao, Shi-Qiang Wang, Mian Long, Thorsten Wohland, Boon Tin Chua, Yujie Sun, Pilong Li, Xiao-Wei Chen, Li Xu, Feng-Jung Chen*, and Peng Li*. A gel-like condensation of Cidec generates lipid-permeable plates for lipid droplet fusion. Developmental Cell, 2021, 56:2592-2606. (†Co-first authors; *Co-corresponding authors)

9. Jia Wang, Chengsong Yan, Chenqi Xu, Boon Tin Chua, Peng Li*, and Feng-Jung Chen*. Polybasic RKKR motif in the linker region of lipid droplet (LD)-associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids. The Journal of. Biological Chemistry, 2018, 293(50): 19330–19343. (*Co-corresponding authors)

10. Feng-Jung Chen, Jhih-Sian Wong, Ken Y. Hsu, and Long Hsu. Thermally activated state transition technique for femto-Newton-level force measurement. Optics Letters, 2012, 37(9): 1469–1471.

11. Chia-Han Chan†, Feng-Jung Chen†, Ying-Jung Huang, Hsin-Yu Chen, Kuo-Liang Liu, Zhe-Chong Wang, Hwei-Ling Peng, Tri-Rung Yew, Cheng-Hsien Liu, Gunn-Guang Liou, Ken Y. Hsu, Hwan-You Chang, and Long Hsu. Identification of protein domains affecting mechanical properties of Klebsiella pneumoniae type 3 fimbriae. Langmuir, 2012, 28(19): 7428–7435. (†Co-first authors)

12. Feng-Jung Chen†, Chia-Han Chan†, Ying-Jung Huang, Kuo-Liang Liu, Hwei-Ling Peng, Hwan-You Chang, Gunn-Guang Liou, Tri-Rung Yew, Cheng-Hsien Liu, Ken Y. Hsu, and Long Hsu. Structural and mechanical properties of Klebsiella pneumonia type 3 fimbriae. Journal of Bacteriology, 2011, 193(7): 1718–1725. (†Co-first authors)

13. 陈丰荣、李蓬，一种单颗脂滴水平与单细胞水平解析的脂滴降解检测和定量分析方法，2024，专利申请号：202411410885.2（中华人民共和国发明专利）

14. 李蓬、陈丰荣、李时杰、周红文，肝脏病理切片图像的肝小叶炎症检测和定量装置及方法，2024，专利公告号：CN 116563206 B（中华人民共和国发明专利）

15. 李蓬、陈丰荣、李时杰、周红文，一种肝脏病理切片图像的脂肪含量分析装置与方法，2024，专利公告号：CN 116245850 B（中华人民共和国发明专利）

16. 徐琅、刘承贤、杨裕雄、陈丰荣、王威、周忠诚，振荡器、质量测量系统以及质量量测方法，2011，专利公告号：CN 101576404 B（中华人民共和国发明专利）