Professor,Chief Scientist of National Key R&D Program
Tel: 0086-21-31246765
Email: tiemin_liu@fudan.edu.cn
Office Address: Room C113, Building of Life Sciences, Fudan University

Personal Profile

Research Interests
Tiemin Liu is expertized in utilizing the animal model of tissue-specific gene knockout and overexpression, in conjunction with physiology and neuroscience, to elucidate the pathological mechanism of obesity, diabetes and related metabolic syndrome. Focusing on the transforming new discoveries from basic research into novel pharmacological and clinical intervention diseases, he has published more than 50 papers in the journals such as Cell, Cell Metabolism, Nature Neuroscience, Neuron (cover and recommended paper) and et cetera. 

Honors and Awards

• 2014  American Diabetes Association Young Investigator Travel Grant Award

• 2007  Dr. Anna Shawyer Scholarships – University of Toronto

• 2006 Government of Ontario/ Dr. Arnie Aberman Graduate Scholarships in Science and Technology - University of Toronto

Selected Publications

1. Wang R*, Guo S, Tian H, Huang Y, Yang Q, Zhao K, Kuo CH, Hong S, Chen P*, Liu T*. Hypoxic training in obese mice improves metabolic disorder. Front Endocrinol, 2019, 8(10): 527.

2. Kong X*, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T*, Rosen ED*. Brown adipose tissue controls skeletal muscle function via the secretion of myostatin. Cell Metabolism, 2018, 28(4): 631-643.

3. Yong G, Yao T, Deng Z, Sohn JW, Jia S, Huang Y, Kong X,Yu KJ, Wang RT, Chen H, Guo H, Yan J, Cunningham KA, Chang Y*, Liu T*, Williams KW*. TrpC5 mediates acute leptin and serotonin effects via Pomc neurons. Cell Rep, 2017, 18(3): 583-592.

4. Yao T, Deng Z, Yong G, Sun J, Kong X, Huang Y, He Z, Xu Y, Chang Y, Yu K, Findley BG, Berglund ED, Wang R, Guo H, Chen H, Li X, Kaufman RJ, Yan J*, Liu T*, Williams KW*. Ire1α in Pomc neurons is required for thermogenesis and glycemia. Diabetes, 2017, 66(3): 663-673.

5. Berglund ED*, Liu T*, Kong X*, Sohn JW, Vong L, Deng Z, Lee CE, Lee S, Williams KW, Olson DP, Scherer PE, Lowell BB, Elmquist JK. Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia. Nature Neuroscience, 2017, 17(7): 911-913.

6. Liu T*, Kong D*, Shah BP*, Ye C*, Koda S, Saunders A, Ding JB, Yang Z, Sabatini BL and Lowell BB. Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone. Neuron, 2012, 73(3): 511-522.
   a.    Featured by Neuron as Cover: Neuron 73(3): 2012.
   b.    Featured Article by Neuron: Neuron 73(3): 2012.
   c.    Featured by Cell Metabolism with a preview: Transmitter Time: Synaptic plasticity and Metabolic Memory in the Hypothalamus. Cell Metabolism 15: 275-27 (2012).