Part-time PI
Hongyan Wang

Tel: 0086-21-31246611
Office Address: Room A609, Building of Life Sciences, Fudan University


Personal Profile

2018-  Deputy-Dean, Institute of Metabolism and Integrative Biology, Fudan University

2015-  Executive Director, Reproductive and Developmental Research Institute, Fudan University

2012  Chief Scientist of 973 program (2012CB945400)

2010  National Science Fund for Distinguished Young Scholars (2010, 81025003)

2007-  Professor, doctoral supervisor at the School of Life Sciences, Fudan University

2002-2007  Research Associate at Center for Research on Reproduction & Women’s Health, Upenn, USA

1999-2002  Post-doctoral fellow at Monell Center, Philadelphia, USA

1996-1999  Ph.D. in Mol. Genet. at Shanghai Brain Research Institute, Chinese Academy of Science

Research Interests

Our laboratory is focused on the investigation of the genetic causes and molecule mechanisms of the occurrences of major birth defects including congenital heart disease and neural tube defects. Our research mainly involves detection and functional analysis of genome structural variation and disease-causing gene mutations, mechanistic basis of epigenetic modification on the regulation of gene expression. We also aim to elucidate the genetic basis of metabolic imbalance such as folic acid deficiency, as well as the molecular mechanisms of how it affects developmental signaling pathways leading to birth defects.

Team Member

Lei LU


Honors and Awards

  • 2016  First prize of Natural Science Award of National Science and Technology Award for Maternal and Child Health (the first accomplisher), "Mechanism of birth defects caused by de novo mutations"

  • 2015  First prize of Natural Science of Ministry of Education (the first accomplisher) , "Genetic analysis of major birth defects in Chinese population"

  • 2013  National 5.1 Labor Award, Chinese Government 

  • 2010  The Seventh China Youth Female Scientist Award, Chinese Government

  • 2009  Special Research Presentation Award, Association of Chinese Geneticists in America, Honolulu, USA

  • 2004/2005/2006 President’s Presenter Award in American Society for Gynecologic Investigation

Selected Publications

  1. Wang D#, Wang F#, Shi KH#, Tao H, Li Y, Zhao R, Lu H, Duan WY, Qiao, B, Zhao SM*, Wang HY*, Zhao JY* (2017). The Circulating Folate Decrease Induced by a Fidgetin Intronic Variant Is Associated with Reduced Congenital Heart Disease Susceptibility. Circulation (accepted)

  2. Zhao JY#, Qiao B#, Duan WY#, Gong XH, Jiang SS, Ye ZZ, Wang J, Gu ZY, Shen HB, Shi KH, Sun SN, Huang GY*, Jin L*, Wang HY*(2013). Genetic variants reducing MTR gene expression increase risk of congenital heart disease in a Chinese population. European Heart Journal  DOI: 10.1093 /eurheartj/eht221

  3. Zhao JY#, Yang XY#, Shi KH#, Sun SN, Hou J, Ye ZZ, Wang J, Duan WY, Qiao Bin, Chen YJ, Shen HB, Huang GY, Jin L, Wang HY* (2013). A Functional Variant in the Cystathionine b-Synthase Gene Promoter Significantly Reduces Congenital Heart Disease Susceptibility in Han Chinese Population. Cell Research 23:242-253

  4. Zhao JY, Yang XY, Gong XH, Gu ZY, Duan WY, Wang J, Ye ZZ, Shen HB, Shi KH, Hou J, Huang GY, Jin L, Qiao B*, and Wang HY* (2012). A functional variant in MTRR intron-1 significantly increases risk of congenital heart disease in Han Chinese population. Circulation 125:482-490

  5.  Lei YP, Zhang T, Li H, Wu BL, Jin L, Wang HY* (2010). VANGL2 Mutations Identified in Human Cranial Neural-Tube Defects. N Engl J of Med 362 (23):2232-2235

  6. Wang H, Parry S, Macones G, Sammel MD, Kuivaniemi H, Tromp G, Halder I, Shriver MD, Romero R, Strauss JF (2006) A Functional SNP in the Promoter of the SERPINH1 Gene Encoding Hsp47 Increases Risk of Preterm Premature Rupture of Membranes and Preterm Birth in African-Americans. PNAS 103(36):13463-13467

  7. Wang H, Parry S, Macones G, Sammel MD, Ferrand PE, Kuivaniemi H, Tromp G, Halder I, Shriver MD, Romero R, Strauss JF (2004) Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM). Hum Mol Genet 13(21):2659-2669