Professor, Academician of Chinese Academy of Engineering, Chief Physician
Tel: 0086-21-81875361
Email: hywangk@vip.sina.com
Office Address: 3rd Building (6th floor) of Eastern Hepatobiliary Surgery Hospital,225 Changhai Road, Yangpu District, Shanghai 200438, P.R.China

Personal Profile

Professor Hongyang Wang is a chief physician, doctoral supervisor, and an expert in oncology and molecular biology. She is also an academician of Chinese Academy of Engineering, and an academician of Academy of Sciences of Developing Countries. She is currently the director of the National Center for Liver Cancer and the International Cooperative Biological Signal Transduction Research Center. Professor Wang is also the president of Women Scientists Association of China Association for Science and Technology, the vice chairman of China Anti-cancer Association, and the chairman of Precision Medicine Committee of Chinese Medical Association. She has been engaged in the basic and clinical research of cancer for more than a decade. She has already made important achievements in deciphering the mechanism of the transformation of cancer from inflammation, the regulation of tumor associated signal network and the development of diagnostic reagents for liver cancer. She has published more than 200 SCI papers in international influential mainstream journals. In the past five years, Professor Wang and her team has applied for 28 invention patents, 12 of which have already been authorized (3 international patents). The glypican-3 hepatocellular carcinoma (HCC) diagnostic kit has been approved for clinical application by China Food and Drug Administration (CFDA), which is the first diagnostic kit of HCC in China with complete independent property rights. She has also successfully hosted more than a dozen major and key National and Provincial science and technology projects.
Research Interests
She is mainly engaged in the basic and clinical research of malignant tumors, including the pathogenesis of hepatobiliary tumors, the molecular mechanism of inflammation to cancer transformation, regulation of cell signal transduction networks, tumor functional genomics and tumor metabolism as well as the research and development of early diagnosis markers for tumors.
Honors and Awards
Due to the excellent work, her team has won the Innovation Team of National Science and Technology Progress Award. She has been awarded with many prizes, such as the second prize of National Natural Science Prize, the first prize of Natural Science Prize in Shanghai, first prize of Shanghai Medical Science and Technology Prize etc. Professor Wang has also been granted with honors such as 'Shanghai top ten scientific and technological elite 'and' outstanding academic leaders 'in Shanghai. She is also the winner of Amory Pacific distinguished female scientist award and Women Innovation Award etc. Served in the military, she has also been awarded the first, the second and the third class merit respectively for her excellent service.
Selected Publications

1. Tian-Yi Jiang, Yu-Fei Pan, Zheng-Hua Wan, Yun-Kai Lin, Bin Zhu, Zhen-gang Yuan,Yun-Han Ma, Yuan-Yuan Shi, Tian-Mei Zeng, Li-Wei Dong*, Ye-Xiong Tan& Hong-Yang Wang*. PTEN status determines the chemosensitivity to proteasome inhibition in cholangiocarcinoma. Science Translational Medicine 2020 [Epub ahead of print]

2. Xiaofang Zhao, Wenhao Qin, Youhai Jiang, Zhishi Yang, Bo Yuan, Rongyang Dai, Hao Shen, Yao Chen, Jing Fu*, Hongyang Wang*. ACADL plays a tumor-suppressor role by targeting Hippo/YAP signaling in hepatocellular carcinoma. npj Precision Oncology 2020 Mar 25;4:7.

3. Qin WH, Yang ZS, Li M, Chen Y, Zhao XF, Qin YY, Song JQ, Wang BB, Yuan B, Cui XL, Shen F, He J, Bi YF, Ning G*, Fu J*, Wang HY*.High Serum Levels of Cholesterol Increase Antitumor Functions of Nature Killer Cells and Reduce Growth of Liver Tumors in Mice. Gastroenterology. 2020 Jan 20. pii: S0016-5085(20)30118-9. doi: 10.1053/j.gastro.2020.01.028. [Epub ahead of print]

4. Cai J, Chen L, Zhang Z, Zhang X, Lu X, Liu W, Shi G, Ge Y, Gao P, Yang Y, Ke A, Xiao L, Dong R, Zhu Y, Yang X, Wang J, Zhu T, Yang D, Huang X, Sui C, Qiu S, Shen F, Sun H, Zhou W, Zhou J, Nie J, Zeng C, Stroup EK, Zhang X, Chiu BC, Lau WY, He C, Wang H, Zhang W, Fan J. Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma.  Gut. 2019 Jul 29. [Epub ahead of print] （IF=17.1）

5. Wei Y, Chen X, Liang C, Ling Y, Yang X, Ye X, Zhang H, Yang P, Cui X, Ren Y, Xin X, Li H, Wang R, Wang W, Jiang F, Liu S, Ding J, Zhang B, Li L*, Wang H*.A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma. Hepatology. 2020 Jan;71(1):130-147.（IF= 14.079）

6. Cheng Z, He Z, Cai Y, Zhang C, Fu G, Li H, Sun W, Liu C, Cui X, Ning B, Xiang D, Zhou T, Li X, Xie W*, Wang H*, Ding J*. Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors. Cell Res. 2019 Feb;29(2):124-135. （IF=15.4 ）

7. Liu J, Jiang J, Mo J, Liu D, Cao D, Wang H, He Y, Wang H*. Global DNA 5-hydroxymethylcytosine and 5-formylcytosine contents are decreased in the early stage of hepatocellular carcinoma. Hepatology. 2019 Jan;69(1):196-208（IF= 14.079）

8. Fu GB, Huang WJ, Zeng M, Zhou X, Wu HP, Liu CC, Wu H, Weng J, Zhang HD, Cai YC, Ashton C, Ding M, Tang D, Zhang BH, Gao Y, Yu WF, Zhai B, He ZY, Wang HY*, Yan HX*. Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens. Cell Res. 2019 Jan;29(1):8-22（IF=15.4 ）

9. Fang T, Lv H, Lv G, Li T, Wang C, Han Q, Yu L, Su B, Guo L, Huang S, Cao D, Tang L, Tang S, Wu M, Yang W*, Wang H*.Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer. Nat Commun. 2018 Jan 15;9(1):191. （IF=12.353）

10. Wang B, Fu J, Yu T, Xu A, Qin W, Yang Z, Chen Y*, Wang H*. Contradictory Effects of Mitochondria- and Non-mitochondria-targeted Antioxidants on Hepatocarcinogenesis by Altering DNA Repair. Hepatology 2017 Sep 12. doi: 10.1002/hep.29518. （IF=11.711）

11. Xi-Meng Lin, Liang Hu, Jin Gu, Ruo-Yu Wang, Liang Li, Jing Tang, Bao-Hua Zhang, Xing-Zhou Yan, Yan-Jing Zhu, Cong-Li Hu, Wei-Ping Zhou, Frank J Gonzalez, Meng-Chao Wu, Hong-Yang Wang*, and Lei Chen*.Choline Kinase Alpha-Driven Assembly of EGFR and mTORC2 Promotes Hepatocellular Carcinoma Metastasis and Drug Resistance. Gastroenterology 2017 Apr 1, 152:1187-1202（IF=18.187）

12. Yang Y, Chen L, Gu J, Zhang H, Yuan J, Lian Q, Lv G, Wang S, Wu Y, Yang YT, Wang D, Liu Y, Tang J, Luo G, Li Y, Hu L, Sun X, Wang D, Guo M, Xi Q, Xi J, Wang H, Zhang MQ, Lu ZJ*. Recurrently deregulated lncRNAs in hepatocellular carcinoma. Nat Commun. 2017 Feb 13;8:14421. doi: 10.1038/ncomms14421（IF=11.47）

13. Wu H, Zhou X, Fu GB, He ZY, Wu HP, You P, Ashton C, Wang X, Wang HY*, Yan HX*. Reversible transition between hepatocytes and liver progenitors for in vitro hepatocyte expansion. Cell Res. 2017 May;27(5):709-712（IF=15.606）

14. Ke S, Chen S, Dong Z, Hong CS, Zhang Q, Tang L, Yang P, Zhai J, Yan H, Shen F, Zhuang Z, Wen W*, Wang H*.Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations. Hepatology. 2017 Jan;65(1):134-151（IF=11.711）

15. Hou G, Chen L, Liu G, Li L, Yang Y, Yan HX, Zhang HL, Tang J, Yang YC, Lin X, Chen X, Luo GJ, Zhu Y, Tang S, Zhang J, Liu H, Gu Q, Zhao LH, Li Y, Liu L*, Zhou W*, Wang H*. Aldehyde Dehydrogenase-2 (ALDH2) Opposes HCC Progression By Regulating AMPK Signaling. Hepatology. 2017 May;65(5):1628-1644（IF=11.055）

16. Yun-Han Ma, Wei-Tao Dou, Yu-Fei Pan, Li-Wei Dong, Ye-Xiong Tan, Xiao-Peng He,* He Tian, and Hong-Yang Wang* . Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues. Adv Mater. 2017 Feb;29(5). doi: 10.1002/adma.201604253. Epub 2016 Nov 21. （IF=18.96）

17. Qu L, Ding J, Chen C, Wu ZJ, Liu B, Gao Y, Chen W, Liu F, Sun W, Li XF, Wang X, Wang Y, Xu ZY, Gao L, Yang Q, Xu B, Li YM, Fang ZY, Xu ZP, Bao Y, Wu DS, Miao X, Sun HY, Sun YH, Wang HY*, Wang LH*. Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA. Cancer Cell. 2016 May 9;29(5):653-68 (IF= 23.214)

18. Ling-Hao Zhao, Xiao Liu, He-Xin Yan, Wei-Yang Li, Xi Zeng, Yuan Yang, Jie Zhao,Shi-Ping Liu, Xue-Han Zhuang, Chuan Lin, Chen-Jie Qin, Yi Zhao, Ze-Ya Pan, Gang Huang, Hui Liu,Jin Zhang, Ruo-Yu Wang, Yun Yang, Wen Wen, Gui-Shuai Lv, Hui-Lu Zhang, Han Wu, Shuai Huang,Ming-Da Wang, Liang Tang, Hong-Zhi Cao, Ling Wang, Tin-Lap Lee, Hui Jiang, Ye-Xiong Tan,Sheng-Xian Yuan, Guo-Jun Hou, Qi-Fei Tao, Qin-Guo Xu, Xiu-Qing Zhang, Meng-Chao Wu, Xun Xu,Jun Wang, Huan-Ming Yang, Wei-Ping Zhou & Hong-Yang Wang* . Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun. 2016 Oct 5;7:12992（IF=11.47）

19. Yang C, Tan YX, Yang GZ, Zhang J, Pan YF, Liu C, Fu J, Chen Y, Ding ZW, Dong LW, Wang HY*. Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.J Exp Med. 2016 May 2;213(5):859-75. doi: 10.1084/jem.20151208. Epub 2016 Apr 18 (IF= 11.24)

20. Yang Y, Lin X, Lu X, Luo G, Zeng T, Tang J, Jiang F, Li L, Cui X, Huang W, Hou G, Chen X, Ouyang Q, Tang S, Sun H, Chen L, Gonzalez FJ, Wu M, Cong W, Chen L*, Wang H*. Interferon-microRNA signalling drives liver precancerous lesion formation and hepatocarcinogenesis. Gut. 2016 Jul;65(7):1186-201 (IF=14.921)