Professor, Chief Physicia
Office Address: 3rd Floor, Building 3, Zhongshan Hospital, Fudan University
MD, PhD. Professor and Director, Department of Endocrinology and Metabolism, Zhongshan Hospital Fudan University. Dr. Li obtained MD from Hengyang Medical College(currently Nanhua University) in 1983 and PhD from Shanghai Second Medical University(currently Shanghai Jiao Tong University School of Medicine) in 1996. Dr. Li was trained for Endocrinology in Xinqiao Hospital, the Third Military Medical University and as a postdoctoral fellow in Baylor College of Medicine, USA in 1998-2000 and in McGill University, Canada in 2000-2003. He is vice president of Chinese Diabetes Society, an associate editor of Endocrine Reviews and Journal of Diabetes and an editor of Diabetes, Chinese Journal of Endocrinology and Metabolism and Chinese Journal of Diabetes. He has published more than 90 scientific papers as in peer review international journals, including Cell Metabolism, PNAS, J Clin Invest, Nature communications, JAMA Internal Medicine, Diabetes, Gut, Gastroenterology, J Hepatology, J Clin Endocrinol Metab etc.
Obesity, fatty liver diseases and type 2 diabetes.
Lu Y, E Wang E, Chen Y, Zhou B, Zhao JJ, Xiang LP, Qian YL, Jiang JJ, Zhao L, Xiong XL, Lu ZQ, Wu DJ, Liu B, Yan J, Zhang R, Zhang HJ, Hu C, Li XY. Obesity-induced excess of 17-hydroxyprogesterone promotes hyperglycemia through activation of glucocorticoid receptor. J Clin Invest, 2020, accepted.
Liu B, Zhang Z, Hu Y, Lu Y, Li D, Liu J, Liao S, Hu M, Wang Y, Zhang D, Hu C, Xiong X, Li XY. Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14. Proc Natl Acad Sci U S A, 2019, 116(43): 21732-21738.
Zhao J, Xiong X, Li Y, Liu X, Wang T, Zhang H, Jiao Y, Jiang J, Zhang H, Tang Q, Gao X, Li X, Lu Y, Liu B, Hu C, Li XY. Hepatic F-Box Protein FBXW7 Maintains Glucose Homeostasis Through Degradation of Fetuin-A. Diabetes, 2018, 67(5): 818-830.
Wu L, Lu Y, Jiao Y, Liu B, Li SG, Li Y, X FY, Chen DB, Liu X, Zhao JJ, Xiong XL, Gu YY, Chen XJ, Li XY. Paternal Psychological Stress Reprograms Hepatic Gluconeogenesis in Offspring. Cell Metabolism, 2016, 23(4): 735–743.
Zhang HJ, He J, Pan LL, Ma ZM, Han CK, Chen CS, Chen Z, Han HW, Chen S, Sun Q, Zhang JF, Li ZB, Yang SY, Li XJ, Li XY. Effects of Moderate and Vigorous Exercise on Nonalcoholic Fatty Liver Disease: A Randomized Clinical Trial. JAMA Intern Med, 2016, 176(8): 1074-1082.
Wang X, Lu Y, Wang E, Zhang Z, Xiong X, Zhang H, Lu J, Zheng S, Yang J, Xia X, Yang S, Li XY. Hepatic estrogen receptor α improves hepatosteatosis through upregulation of small heterodimer partner. J Hepatol, 2015, 63(1): 183-190.
Xiong X, Wang X, Lu Y, Wang E, Zhang Z, Yang J, Zhang H, Li XY. Hepatic steatosis exacerbated by endoplasmic reticulum stress-mediated downregulation of FXR in aging mice. J Hepatol, 2014, 60(4): 847-854.
Lu Y, Ma Z, Zhang Z, Xiong X, Wang X, Zhang H, Shi G, Xia X, Ning G, Li XY. Yin Yang 1 promotes hepatic steatosis through repression of farnesoid X receptor in obese mice. Gut, 2014, 63(1): 170-178.
Lu Y, Liu X, Jiao Y, Xiong X, Wang E, Wang X, Zhang Z, Zhang H, Pan L, Guan Y, Cai D, Ning G, Li XY. Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα. J Clin Invest, 2014, 124(8): 3501-3513.
Lu Y, Xiong XL, Wang XL, Zhang ZJ, Li J, Shi GJ, Yang J, Zhang HJ, Ning G, Li XY. Yin Yang 1 promotes hepatic gluconeogenesis through upregulation of glucocorticoid receptor. Diabetes, 2013, 62(4): 1064-1073.