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Representative Publications-2018
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Xu D , Li Y, Wu L, Li Y,  Zhao D, Yu J,  Huang T,  Ferguson C, Parton RG., Yang H, Li P.Rab18 promotes lipid droplet growth by tethering ER and LD through interaction between NRZ and SNARE.J Cell Biolhttps://doi.org/10.1083/jcb.201704184
Zhou L, Yu M, Arshad M, Wang W, Lu Y, Gong J, Gu Y, Li P, Xu L.Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes.Diabeteshttps://doi.org/10.2337/db17-1452
Wang J, Yan C, Xu C, Chua BT, Li P, Chen FJ.Polybasic RKKR motif in the linker region of lipid droplet (LD)-associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids.J Biol Chemhttps://doi.org/10.1074/jbc.ra118.004892
Lv X, Liu J, Qin Y, Liu Y, Jin M, Dai J, Chua BT, Yang H, Li P.Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysis.Biochim Biophys Acta (Mol Cell Biol Lipids)https://doi.org/10.1016/j.bbalip.2018.11.001
Kim J, Lei Y, Guo J, Kim SE, Wlodarczyk BJ, Cabrera RM, Lin YL, Nilsson TK, Zhang T, Ren A, Wang L, Yuan Z, Zheng YF, Wang HY.Finnell RH. Formate rescues neural tube defects caused by mutations in Slc25a32.Proc Natl Acad Sci U S Ahttps://doi.org/10.1073/pnas.1800138115
Chen Z, Kuang L, Finnell RH, Wang H.Genetic and functional analysis of SHROOM1-4 in a Chinese neural tube defect cohort.Hum Genethttps://doi.org/10.1007/s00439-017-1864-x
Li B, Yu L, Liu D, Yang X, Zheng Y, Gui Y, Wang H.MIB1 mutations reduce Notch signaling activation and contribute to congenital heart disease.Clin Sci (Lond)https://doi.org/10.1042/cs20180732
Chen Z, Lei Y, Zheng Y, Aguiar-Pulido V, Ross ME, Peng R, Jin L, Zhang T, Finnell RH, Wang H.Threshold for neural tube defect risk by accumulated singleton loss-of-function variants.Cell Reshttps://doi.org/10.1038/s41422-018-0061-3
Chen Z, Lei Y, Cao X, Zheng Y, Wang F, Bao Y, Peng R, Finnell R, Zhang T, Wang H.Genetic analysis of Wnt/PCP genes in neural tube defects.BMC Med Genomicshttps://doi.org/10.1186/s12920-018-0355-9
Chen Z, Kuang L, Finnell RH, Wang H.Genetic and functional analysis of SHROOM1-4 in a Chinese neural tube defect cohort.Hum Genethttps://doi.org/10.1007/s00439-017-1864-x
He XD, Gong W, Zhang JN, Nie J, Yao CF, Guo FS, Lin Y, Wu XH, Li F, Li J, Sun WC, Wang ED, An YP, Tang HR, Yan GQ, Yang PY, Wei Y, Mao YZ, Lin PC, Zhao JY, Xu YH, Xu W, Zhao SM.Sensing and transmitting intracellular amino acid signals through reversible lysine aminoacylations.Cell Metabolismhttps://doi.org/10.1016/j.cmet.2017.10.015
Zhang Q, Bai B, Mei X, Wan C, Cao H, Dan Li, Wang S, Zhang M, Wang Z, Wu J, Wang H, Huo J, Ding G, Zhao J, Xie Q, Wang L, Qiu Z, Zhao S, Zhang T.Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects.Nat Communhttps://doi.org/10.1038/s41467-018-05451-7
Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T, Rosen ED.Brown adipose tissue controls skeletal muscle function via the secretion of myostatin.Cell Metabolismhttps://doi.org/10.1016/j.cmet.2018.07.004
Wei Q, Gu YF, Zhang QJ, Yu H, Peng Y, Williams KW, Wang R, Yu K, Liu T, Liu ZP.Lztfl1/BBS17 controls energy homeostasis by regulating the leptin signaling in the hypothalamic neurons.Journal of Molecular Cell Biologyhttps://doi.org/10.1093/jmcb/mjy022
Qian H, Chen Y, Huang T, Liu T, Li X, Jiang G, Zhang W, Cheng S, Li P.Combined application of Embelin and tumor necrosis factor-related apoptosis-inducing ligand inhibits proliferation and invasion in osteosarcoma cells via caspase-induced apoptosis.Oncology Lettershttps://doi.org/10.3892/ol.2018.8209
Huang Y, He Z, Gao Y, Lieu L, Yao T, Sun J, Liu T, Javadi C, Box M, Afrin S, Guo H, Williams KW.Phosphoinositide 3-kinase is integral for the acute activity of leptin and insulin in male arcuate NPY/AgRP neurons.Journal of the Endocrine Societyhttps://doi.org/10.1210/js.2018-00061
Zhang X, Niu Y, Wang X, Liu ZP, Liu T, Wang RT.Mean platelet volume and platelet distribution width are associated with gallbladder cancer.Asian Pacific Journal of Cancer Preventionhttps://doi.org/10.22034/apjcp.2018.19.2.351
Peng J, Li Y, Wang X, Deng S, Holland J, Yates E, Chen J, Gu H, Essandoh K, Mu X, Wang B, McNamara RK, Peng T, Jegga AG, Liu T, Nakamura T, Huang K, Perez-Tilve D, Fan GC.An Hsp20-FBXO4 axis regulates adipocyte function through modulating PPARγ ubiquitination.Cell Reportshttps://doi.org/10.1016/j.celrep.2018.05.065
Liu M#, Zeng T#, Zhang X#, Liu C, Wu Z, Yao L, Xie C, Xia H, Lin Q, Xie L, Zhou D, Deng X, Chan HL, Zhao TJ*, Wang HR*.ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage.Nat Communhttps://doi.org/10.1038/s41467-018-06556-9
Fang T, Lv H, Lv G, Li T, Wang C, Han Q, Yu L, Su B, Guo L, Huang S, Cao D, Tang L, Tang S, Wu M, Yang W*, Wang H*.Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer.Nat Communhttps://doi.org/10.1038/s41467-017-02583-0
Zhao J, Xiong X, Li Y, Liu X, Wang T, Zhang H, Jiao Y, Jiang J, Zhang H, Tang Q, Gao X, Li X, Lu Y, Liu B, Hu C, Li XY.Hepatic F-Box Protein FBXW7 Maintains Glucose Homeostasis Through Degradation of Fetuin-A.Diabeteshttps://doi.org/10.2337/db17-1348


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