Tel: 0086-21-31242085
Email: yangtianshuu@163.com

Office Address: Room D7011, Interdisciplinary Building No.2, Fudan University

Personal Profile

Dr. Yang obtained her B.S. in Biological Science in Tsinghua University in 2007 and Ph.D. in Translational Biology and Molecular Medicine in Baylor College of Medicine. She has studied the molecular mechanisms underlying  immunodeficiency in MeCP2 duplication syndrome. She joined Tongji University School of Medicine in 2013 and worked there as an assistant professor and then associate professor. During 2013-2020, she has focused on the regulatory role of novel immune cytokines in angiogenesis and tumor progression. She joined Institute of Metabolism and Integrative Biology of Fudan University in 2020.

Research Interests

Immune cells’ activation and differentiation is associated with metabolic reprogramming. Immune cells’ metabolism influences their differentiation, function and homeostasis. We are mainly interested in:
1. The effect of metabolism on the pathogenesis of inflammatory lung diseases including asthma, pneumonia, influenza;
2. The effect of metabolism on immune cell function;
3. The effect of metabolism on disease tolerance in systemic inflammation.

Selected Publications

1. Yang T, Ge B*. miRNAs in immune responses to Mycobacterium tuberculosis infection. Cancer Lett. 2018, 431: 22-30.

2. Zhao M, Hu Y, Jin J, Yu Y, Zhang S, Cao J, Zhai Y, Wei R, Shou J, Cai W, Liu S, Yang X, Xu GT, Yang J, Corry DB, Su SB, Liu X*, Yang T*. Interleukin 37 promotes angiogenesis through TGF-β signaling. Sci Rep. 2017, 7(1): 6113.

3. Shou J, Cao J, Zhang S, Sun R, Zhao M, Chen K, Su SB, Yang J, Yang T*. SIS3, a specific inhibitor of smad3, attenuates bleomycin-induced pulmonary fibrosis in mice. Biochem Biophys Res Commun. 2018, 503(2): 757-776.

4. Lu J, Guan S, Zhao Y, Yu Y, Woodfield SE, Zhang H, Yang KL, Bieerkehazhi S, Qi L, Li X, Gu J, Xu X, Jin J, Muscal JA, Yang T*, Xu GT*, Yang J*. The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model. Cancer Lett. 2017, 400: 61-68.

5. Lu J, Guan S, Zhao Y, Yu Y, Wang Y, Shi Y, Mao X, Yang KL, Sun W, Xu X, Yi JS, Yang T*, Yang J*, Nuchtern JG*. Novel MDM2 inhibitor SAR405838 (MI-773) induces p53-mediated apoptosis in neuroblastoma. Oncotarget. 2016, 7(50): 82757-82769.

6. Zhao M, Hu Y, Shou J, Su SB, Yang J, Yang T*. IL-37 impairs host resistance to Listeria infection by suppressing macrophage function. Biochem Biophys Res Commun. 2017, 485(2): 563-568.

7. Zhao M#, Hu Y#, Yu Y, Lin Q, Yang J, Su SB, Xu GT*, Yang T*. Involvement of IL-37 in the Pathogenesis of Proliferative Diabetic Retinopathy. Invest. Ophthalmol. Vis Sci. 2016, 57(7): 2955-2962.

8. Yang T#,*, Lin Q#, Zhao M#, Hu Y#, Yu Y, Jin J, Zhou H, Hu X, Wei R, Zhang X, Yang X, Liu G, Lu P, Xu G, Yang J, Corry DB, Su SB, Liu S*, Liu X*. IL-37 Is a Novel Proangiogenic Factor of Developmental and Pathological Angiogenesis. Arterioscler Thromb Vasc Biol. 2015, 35(12): 2638-2646.

9. Zhang L#, Wang H#, Yang T#, Su Z#, Fang D, Wang Y, Fang J, Hou X, Le Y, Chen K, Wang JM, Su SB, Lin Q*, Zhou Q*. Formylpeptide receptor 1 mediates the tumorigenicity of human hepatocellular carcinoma cells. Oncoimmunology. 2015, 5(2): e1078055.

10. Yang S#, Yang TS#, Wang F*, Su SB*. High-mobility group box-1-Toll-Like receptor 4 axis mediates the recruitment of endothelial progenitor cells in alkali-induced corneal neovascularization. Int Immunopharmacol. 2015, 28(1): 450-458.

11. Yang S, Xu L, Yang T*, Wang F*. High-mobility box-1 and its role in angiogenesis. J Leukocyte Biol. 2014, 95(4): 563-574.

12. Yang T, Ramocki MB*, Neul JL, Wen L, Roberts L, Knight JM, Ward CS, Zoghbi H, Kheradmand F, Corry DB*. Overexpression of methyl-CpG binding protein 2 impairs Th1 responses and causes immunodeficiency. Sci Transl Med. 2012, 4(163): 163ra158.

13. Lu W, You R, Yuan X, Yang T, Samuel EL, Marcano DC, Sikkema WK, Tour JM, Rodriguez A, Kheradmand F, Corry DB*. The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote TH17 cell-dependent emphysema. Nat Immunol. 2015;16(11):1185-1194.

14. Ye J, Li JZ, Liu Y, Li X, Yang T, Ma X, Li Q, Yao Z, Li P*. Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B. Cell Metab. 2009, 9 (2): 177-190.