Tel: 0086-21-65643983

   Email: chdeng@fudan.edu.cn

  Office Address: Room A4017, Chemistry Building, Jiangwan Campus, Fudan University

Personal Profile

Chunhui Deng, professor of Fudan University, doctoral supervisor, recipient of the National Science Fund for Distinguished Young Scholars. From 1998 to 2001, he studied for a master's degree in analytical chemistry at the Analysis Center of Fudan University. From 2001 to 2004, he studied for a Ph.D. in analytical chemistry in the Department of Chemistry, Fudan University. In July 2004, he obtained a Ph.D. degree in science, and in the same year, he worked in the Department of Chemistry of Fudan University. In 2010, he was employed as a professor and doctoral supervisor of Fudan University. He published a total of 320 research papers in important international journals such as Chemical Society Reviews, Journal of the American Chemical Society, Angewandta Chemie-international Edition, Advanced Functional Materials, Analytical Chemistry, Chemical Communications, Nanoscale, Journal of Materials Chemistry, ACS Applied Materials & Interfaces, etc. The papers have been cited more than 14,000 times, with the H factor of 64,

Research Interests

The group mainly focuses on the development of new technologies and new methods of proteomics based on functionalized magnetic nanomaterials and metabolomics research based on MALDI-MS. Aiming at the hot and difficult problems in proteomic research in terms of protein enzymatic hydrolysis, enrichment of low-abundant proteins and endogenous peptides, selective separation and enrichment of modified proteins, and physiological and pathological research of exosomes and metabolic small molecules, the group works on low-abundance proteins and endogenous peptides separation and enrichment of functionalized magnetic nanomaterials, selective separation and enrichment of modified proteins, single-cell and body fluid metabolite analysis, exosome separation and analysis, and disease peptidomics.

Honors and Awards

• 2014, National Science Fund for Distinguished Young Scholars

• 2015, The second prize of Shanghai Science and Technology Progress Award

• 2011, The second prize of the Natural Science Award of the Ministry of Education

• 2010, Meiji Dairy Life Science Award

• He has presided over and participated in the completion of major and general projects of the National Natural Science Foundation of China, the S973 project, and the National Science Fund for Distinguished Young Scholars.

Selected Publications

1. Chen HL, Zhang N, Wu YL, Yang CJ, Xie QH, Deng CH*, Sun NR*. Investigation of Urinary Exosome Metabolic Patterns in Membranous Nephropathy by Titania-Assisted Intact Exosome Mass Spectrometry. Small Sci, 2022, DOI: 10.1002/smsc.202100118.

2. Yang CJ, Yu HL, Hu XF, Chen HL, Wu H, Deng CH*, Sun NR*. Gold-Doped Covalent-Organic Framework Reveals Specific Serum Metabolic Fingerprints as Point of Crohn's Disease Diagnosis. Adv. Funct. Mater., 2021, 31 (45).

3. Sun NR, Wu H, Shen XZ*, Deng CH*. Nanomaterials in Proteomics. Adv. Funct. Mater., 2019, 29 (26).

4. Wu YL#, Chen YJ#, Chen HL, Yang CJ, Shen XZ, Deng CH*, Sun NR*, Wu H. Probing serum N-glycan patterns for rapid and precise detection of Crohn's disease. Chem. Commun., 2021, 57 (86): 11362-11365.

5. Zhang N, Hu XF, Chen HL, Deng CH*, Sun NR*, Specific enrichment and glycosylation discrepancy profiling of cellular exosomes using a dual-affinity probe. Chem. Commun., 2021, 57 (51): 6249-6252.

6. Li Y, Zhang XM, Deng CH*. Functionalized magnetic nanoparticles for sample preparation in proteomics and peptidomics analysis. Chemical Society Reviews, 2013, 42(21): 8517-8539.

7. Zhang XY, Zhu SC, Ya X, Deng CH*, Zhang XM*. Development of a MALDI-TOF MS Strategy for the High-Throughput Analysis of Biomarkers: On-Target Aptamer Immobilization and Laser-Accelerated Proteolysis. Angewandte Chemie International Edition, 2013, 52(23): 6055-6058.

8. Sun NR, Wang JW, Yao JZ, Deng CH*. Hydrophilic Mesoporous Silica Materials for Highly Specific Enrichment of N Linked Glycopeptide. Analytical Chemistry, 2017, 89 (3): 1764-1771.

9. Li YL, Wang JW, Sun NR*, Deng CH*. Glucose-6-Phosphate-Functionalized Magnetic Microsphere as Novel Hydrophilic Probe for Specific Capture of N-Linked Glycopeptides. Analytical Chemistry, 2017, 89 (20): 11151–111583.