科学研究
发表论著
2026年代表性论著
| 作者 | 标题 | 期刊名 | 论文链接 |
| Liu T, Zhou JH, Gong Y, Zhang Y, Ma Y, Zhang X, Minhajuddin M, Song W, Zhuang Z, Vujovic A, Lu Y, Jia A, Guo R, Ren R, Zhou L, Xiong Y, Huang L, Du X, Zhao TJ, Li P, Jordan CT, Ye H. | A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential | Cell Reports | https://doi.org/10.1016/j.celrep.2025.116496 |
| Niu Y, Hu S, Zhang Y, Yang J, Zhang J, He R, Chen L, Xu L, Zhao H, Gan B, Ren R, Loos RJF, Ye H, Du X, Zhao T, Li P, Vidal-Puig A, Huang L. | Lactate-activated GPR81/FARP1 signaling drives insulin-independent glucose uptake and metabolic control | Cell Research | https://www.nature.com/articles/s41422-025-01207-3 |
| Wu C, Yang H, Wang C, Huang P, Yan N, Ren R, Liu W, Lu Y, Chang C. | ER membrane receptors engage core autophagy machinery to initiate ER phagy | PNAS | https://doi.org/10.1073/pnas.2523465123 |
| Jia A, Zhang X, Zhou JH, Ma Y, Wang J, Gong Y, Song W, Hu H, Yu Y, Yang H, Lu Y, Huang L, Du X, Chang C, Pei S, Li P, Jordan CT, Zhao TJ, Ye H. | Dual Targeting of SLC25A51 and Succinate Dehydrogenase Selectively Depletes Mitochondrial NAD+ to Eradicate KRAS-Driven AML | Cell Metabolism | https://doi.org/10.1016/j.cmet.2026.01.001 |
| Li L, You J, Chai ZQ, Li X, Cai X, Wang L, Yang F, Zhu L, Mi W, Xia X, Yan H, Li F, Wang J, Zhao TJ, Chen L, Ji H, Liu P, Zhou XL, Chen L, Li F. | SLC6A6 imports taurine into mitochondria to sustain mitochondrial translation and tumour growth | Nature Metabolism | https://www.nature.com/articles/s42255-026-01455-6 |
| Wang Y, Zhu JX, Zhan FX, Guo Y, Xia Y, Liu J, Dai P, Hu Y, Chen YH, Luan XH, Shen XY, Cao YW, Huang X, Zhang X, Cao L, Hou SX. | PML targets and resolves structured protein inclusions to mitigate neurodegeneration | Nature Cell Biology | https://www.nature.com/articles/s41556-026-01894-z |
| Wu J, Liu S, Dan W, Tong X, Gong J, Li Z, Gu Y, Xu J, Chen W, Wang S, Luo XY, Yang H, Jia Y, Chang CH, Yan K, Wang J, Huang LH. | Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages | Cell Metabolism | https://www.cell.com/cell-metabolism/fulltext/S1550-4131(26)00057-4 |
| Ding Y, Fang W, Xiang R, Liu H, Huang M, Shen Y, Chen Y, Wang G, Zhou Z, Ling Y, Sun LV, Wang Y, Hou SX. | Inhibition of the cancer stem cell immune checkpoint SOAT1 suppresses regulatory T cell functions through a trans-cellular 20(S)-Hydroxycholesterol-GPR132 pathway in mice | Nature Communications | https://www.nature.com/articles/s41467-026-69305-3 |
| Wu B, Zeng W, Tang K, Xiong J, Mo X, Fu Q, Fu D, Chu R, Zhao G, Lu L, Wang Z, Wu L, Yu Z, Zhou X, Wang H. | Increased PRSS56 expression is a causal factor and therapeutic target for human axial high myopia | Cell Research | https://www.nature.com/articles/s41422-026-01241-9 |
| Yu L, Jiao H, Pang B, Ti R, Gan B, Qin Z, Wang J, Zhu L, Hu H, Ren R. | Structural insights into subtype-specific agonist recognition by Sphingosine-1-phospate receptors | PLoS Biology | https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003381 |
| Sun T, Tao Y, Zeng Y, Ai R, Li T, Li X, Li X, He R, Jia Z, Sun X, Feng Z, Liu X, Kong X, Huang L, Chen L, Ni J, Chen L, Dai W. | Increased Yolk Lipid Mobilization Promotes Zebrafish Post-Segmentation Growth via an Hnf4-Lipoprotein Axis | Cell Reports | https://doi.org/10.1016/j.celrep.2026.117295 |
| Tan Z, Qi Y, Chen Y, Zhang L, Li C, Lei B, Xiao Z, Zhang J, Lu L, Wang H. | Aberrant Phase Separation of Endothelial MAML1 Causes Congenital Heart Disease by Suppressing Notch Activity | Circulation | https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.078188 |
| Mi W, Xia X, Xue Y, Li L, Yang L, Yang X, Xu J, Cai X, Zhou Y, Zhu L, Wang G, Li F, Ji H, Tong X, Liu P, Li F. | LKB1 inactivation elicits an NNMT-mediated methyl sink and confers dependence on PRMT5 in lung cancer | Cell Reports | https://doi.org/10.1016/j.celrep.2026.117487 |
| Zhang X, Ai R, Zeng Y, Xu Y, Shao W, Yao J, Tian X, Zhu Z, Pi Y, Dai W. | Neutrophil-Promoted Macrophage State Transition Coordinates Endothelial Migration and Barrier Resealing in Zebrafish Microvascular Repair | Cell Reports | https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00840-5 |
| Yang R, Sun Y, Wang W, Lei Y, Chen L, Li X, Liu RB, Zhou A, Gao AW, Mu L, Auwerx J, Li TY. | Mitochondrial stress activates ELT-2–dependent lysosomal proteostasis to extend lifespan in C. elegans | Science Advances | https://doi.org/10.1126/sciadv.aeh0657 |
| Lv R, Yu L, Liu J, Zhou Y, He R, Wang C, Gan B, Ti R, Jiao H, Song B, Chen Y, Lin F, Gao M, Hu H, Yin S, Zhou P, Zhu L, Cai M, Xie T, Liu J, Chen L, Zhong Y, Ren R. | Molecular basis of HACD-TECR complex mediated very-long-chain fatty acid elongation reveal a potential target in colorectal cancer | Science Advances | https://doi.org/10.1126/sciadv.aeh5593 |
| Wang J, Ni Z, Zhang X, He L, Zhang X, Cheng X, Wang H, Sun G, Lu Z, Liu C, Qian H, Lu Y, Liu G, Jia J, Ye J, Huang L, Ye H, Li R, Tao W, Li P, Zhao TJ, Du X. | Amino acid homeostasis by CORVET/HOPS: A metabolic and stress resilience checkpoint for T cells | PNAS | https://www.pnas.org/doi/10.1073/pnas.2601318123 |
| Fang Y, Tang J, Xi J, Yang B, Zhang F, Wang L. | Donor-complementary prime editing enables precise kilobase and library-compatible DNA insertions | Nature Biotechnology | https://www.nature.com/articles/s41587-026-03296-w |
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