兼职教师
夏明锋

特聘研究员,副教授,副主任医师

邮箱:xia.mingfeng@zs-hospital.sh.cn

地址:上海市枫林路180号



个人简介

夏明锋,毕业于复旦大学八年制临床医学专业,曾至美国得克萨斯大学西南医学中心访学。目前担任复旦大学附属中山医院内分泌肥胖脂肪肝亚专科主任。中国药理学会内分泌与代谢药理委员会常委,中国医师协会内分泌代谢分会青年委员、中国生物物理学会代谢生物学分会青年委员、上海市生物医学工程学会代谢医学工程专委会委员。长期致力于代谢功能障碍相关性脂肪性肝病的无创诊断、发病机制和干预策略研究。

主要成果贡献包括:1.建立1项原创的肝脏脂肪无创定量技术和1项基于代谢组学的代谢相关脂肪性肝炎无创预测模型,实现肝脏脂肪含量的无创定量和对代谢相关脂肪性肝炎的高效筛查。2.系统解析汉族人群PNPLA3、TM6SF2等基因多态性变异导致代谢相关脂肪性肝病的作用和机制。3.创新性发现MASLD治疗的原创药物靶点1个(DRAK2);揭示国外原研新药改善MASLD双重作用机制1项(DGAT2),推动其进入2/3期临床研究。

依托上述工作,近5年以第一或通讯作者身份在Cell Metabolism、J Hepatol等杂志发表SCI论文33篇,推进了代谢相关脂肪性肝病的无创诊断方法进步、发病机制和干预策略创新。申请人先后主持国家自然科学基金项目4项,参与科技部重点研发计划1项。入选教育部长江学者特聘教授、上海市优秀学术带头人、上海市浦江人才(A类)、上海市医苑新星青年医学人才、复旦大学上海医学院临床名医培育工程等人才培养项目,获上海市医学科技二等奖、成果推广奖。在欧洲肝病学会专题会议和欧洲糖尿病学会年会上多次做大会会议报告。

主要研究方向

肝脏脂代谢调控机制和代谢相关脂肪性肝病的精准诊疗

荣誉及获奖情况

2016年上海市医学科技二等奖

2016年上海市医学科技推广奖

代表性成果

  1. Huang QX#, Qadri SF#, Bian H#, Yi XX, Lin CH, Yang XY, Zhu XP, Lin HD, Yan HM, Chang XX, Sun XY, Ma S, Wu Q, Zeng HL, Hu XQ, Zheng Y, Yki-Järvinen H, Gao X*, Tang HR*, Xia MF*. A metabolome-derived score predicts metabolic dysfunction- associated steatohepatitis and mortality from liver disease. J Hepatol 2025; 82: 781-793.

  2. Xia MF#, Zeng HL#, Wang SJ, Tang HR*, Gao X*. Insights into contribution of genetic variants towards the susceptibility of MAFLD revealed by the NMR_based lipoprotein profiling. Journal of Hepatology 2021;74(4):974-977.

  3. Li YF#, Xu JY#, Lu YT#, Bian H#, Yang L, Wu HH, Zhang XW, Zhang BL, Xiong MQ, Chang YF, Tang J, Yang F, Zhao L, Li J, Gao X, Xia MF*, Tan MJ*, Li JY*. DRAK2 aggravates nonalcoholic fatty liver disease  progression through SRSF6-associated RNA alternative splicing. Cell Metabolism. 2021; 33(10): 2004-2020.

  4. Rong S#, Xia M#, Vale G, Wang S, Kim CW, Li S, McDonald JG, Radhakrishnan A, Horton JD. DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER. Cell Metab 2024;36(3):617-629.

  5. Xia MF#, Lin HD#, Chen LY, et al. The PNPLA3 rs738409 C>G variant interacts with changes in body weight over time to aggravate liver steatosis, but reduces the risk of incident type 2 diabetes. Diabetologia 2019;62:644-654.

  6. Zhu XP#, Huang QX#, Ma S#, Chen LY, Wu Q, Wu L, Ma H, Li XM, Li Q, Aleteng Q, Hu Y, He WY, Gao J, Lin HD, Tang HR*, Gao X*, Xia MF*. Presence of sarcopenia identifies a special group of lean NAFLD in   middle-aged and older people. Hepatology International 2023;17:313-325.

  7. Lin C#, Xia M#, Dai Y#, Huang Q, Sun Z, Zhang G, Luo R, Peng Q, Li J, Wang X, Lin H, Gao X, Tang H, Shen X, Wang S, Jin L*, Hao X*, Zheng Y*. Cross-ancestry analyses of Chinese and European populations reveal insights into the genetic architecture and disease implication of metabolites. Cell Genom. 2025;5(4):100810. 

  8. Xia MF, Chen LY, Wu L, Ma H, Li XM, Li Q, Aleteng Q, Hu Y, He WY, Gao J, Lin HD*, Gao X*. Sarcopenia, sarcopenic overweight/obesity and risk of cardiovascular disease and cardiac arrhythmia: A cross-sectional study. Clin Nutr. 2021; 40(2):571-580.

  9. Xia MF#, Rong SX#, Zhu XP, Yan HM, Chang XX, Sun XY, Zeng Hl, Li XM, Zhang LS, Chen LY, Wu L, Ma H, Hu Y, He WY, Gao J, Pan BS, Hu XQ, Lin HD*, Bian H*, Gao X*.Osteocalcin and non-alcoholic fatty liver disease: lessons from two population-based cohorts and animal models. J Bone Miner Res. 2021; 36:712-728.

  10. Xia MF#*, Ma S#, Huang QX#, Zeng HL, Ge JY, Xu WJ, Wu Q, Wu L, Li XM, Ma H, Chen LY, Li Q, Aleteng Q, Hu Y, He WY, Pan BS, Lin HD, Zheng Y, Wang SJ, Tang HR*, Gao X*.NAFLD-related gene polymorphisms and all-cause and cause-specific mortality in an Asian population: the Shanghai Changfeng Study, Alimentary Pharmacology and Therapeutics 2022;55(6): 705-721.