青年研究员

邮箱：renruobing@fudan.edu.cn

办公地址：上海市杨浦区湾谷科技园2期D3座1306室

个人简介

任若冰博士2009年获得中国科学技术大学生命学院生物技术学士学位，2015年获得清华大学生物学博士学位，2015-2017年于Amgen亚洲研发中心任结构生物学副研究员，2018-2021年于香港中文大学（深圳）生命健康科学学院及科比尔卡创新药物研究院担任“准聘-长聘制”助理教授及博士生导师，2021年底加入复旦大学代谢与整合生物学研究院任青年研究员。

主要研究方向

任若冰博士一直从事与重大疾病相关的膜蛋白分子机制研究，通过以X射线晶体学和低温冷冻电子显微镜技术为主的结构生物学研究手段，结合其他生物物理和生物化学分析方法，主要聚焦方向包括：

（1）类固醇激素代谢及其失调引发的内分泌系统疾病的药物开发；

（2）脂肪和脂肪酸代谢及其引发的代谢性疾病的药物开发；

（3）鞘脂分子的代谢及其引发的免疫系统疾病的药物开发；

（4）基于人工智能开发脂质代谢疾病治疗新思路和新方法。

荣誉及获奖情况

• 2018年 深圳市高层次人才A类

• 2018年 深圳市龙岗区深龙英才A类

• 2018年 深圳市龙岗区优秀专家

• 2020年 香港中文大学（深圳）校长青年学者

代表性成果

1. Yu L^*,#, Jiao H^*, Pang B^*, Ti R^*, Gan B, Qin Z, Wang J, Zhu L, Hu H, Ren R^#. Structural insights into subtype-specific agonist recognition by Sphingosine-1-phosphate receptors (2026) PLoS Biology. E-print. https://doi.org/10.1371/journal.pbio.3003381

2. He D^*, Zhang L^*, Yu L^*, Zhang Y, Chen J, Wang L, Hu H, Liu H, Zheng H, Xia J, Chen J, Li C, Li X, Tang H, Liu J^#, Ren R^#, Hu Y^#, Li Z^#. Fine structural design of 3βHSD1 inhibitors for prostate cancer therapy. (2025) Proceedings of the National Academy of Sciences of the United States of America. 122 (26) e2422267122. https://doi.org/10.1073/pnas.2422267122

3. Pang B^*, Yu L^*, Li T^*, Jiao H, Wu X, Wang J, He R, Zhang Y, Wang J, Hu H, Dai W^#, Chen L^#, Ren R^#. Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport. (2024) Cell Research. 34 (2), 173-176. https://doi.org/10.1038/s41422-023-00908-x

4. Jiao H^*, Pang B^*, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang Y^#, Ren R^#, Hu H#. Structural insights into the activation and inhibition of CXC chemokine receptor 3. (2024) Nature Structural & Molecular Biology. 31 (4), 610-620. https://doi.org/10.1038/s41594-023-01175-5

5. Ti R^*, Pang B^*, Yu L^*, Gan B, Ma W, A Warshel. Ren R^#, Zhu L^#. Fine-tuning activation specificity of G-protein-coupled receptors via automated path searching. (2024) Proceedings of the National Academy of Sciences of the United States of America. 121 (8), e2317893121. https://doi.org/10.1073/pnas.2317893121

6. Gan B^*, Yu L^*, Yang H^*, Jiao H, Pang B, Chen Y, Wang C, Lv R, Hu H, Cao Z^#, Ren R^#. The structural basis of itch receptor MRGPRX1 activation. (2023) PLoS Biology. 21 (6), e3001975. https://doi.org/10.1371/journal.pbio.3001975

7. Wang C^*, Yu L^*, Zhang J^*, Zhou Y^*, Sun B, Xiao Q, Zhang M, Liu H, Li J, Luo Y, Xu J, Lian Z, Lin J, Wang X, Zhang P, Guo L^#, Ren R^#, Deng D^#. Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1. (2023) Nature Communications. 14 (1), 1727. https://doi.org/10.1038/s41467-023-37411-1

8. Jiao H^*, Pang B^*, Chiang Y, Chen Q, Pan Q, Ren R^#, Hu H^#. Structure basis for the modulation of CXC chemokine receptor 3 by antagonist AMG487. (2023) Cell Discovery. 9 (1), 119. https://doi.org/10.1038/s41421-023-00617-0

9. Yu L^*, He L^*, Gan B^*, Ti R^*, Xiao Q, Hu H, Zhu L^#, Wang S^#, Ren R^#. Structural insights into sphingosine-1-phosphate receptor activation. (2022) Proceedings of the National Academy of Sciences of the United States of America. 119 (16), e2117716119. https://doi.org/10.1073/pnas.2117716119

10. Han Y^*, Zhuang Q^*, Sun B^*, Lv W^*, Wang S^*, Xiao Q, Pang B, Zhou Y, Wang F, Chi P, Wang Q, Li Z, Zhu L, Li F, Deng D^#, Chiang Y^#, Li Z^#, Ren R^#. The crystal structure of steroid reductase SRD5A reveals a conserved steroid reduction mechanism. (2021) Nature Communications. 12 (1), 449. https://doi.org/10.1038/s41467-020-20675-2

11. Chen G^*, Wang X^*, Ge Y^*, Ma L^*, Chen Q, Liu H, Du Y, Ye D, Hu H^#, Ren R^#. Cryo-EM structure of activated bile acids receptor TGR5 in complex with the stimulatory G protein. (2020) Signal Transduction and Targeted Therapy.  5(1), 142. https://doi.org/10.1038/s41392-020-00262-z

12. Yuan Z, Shen T, Xu S, Yu L, Pang B, Gan B, Feng Q, Ren R^#, Sun S^#. AF2-mutation: adversarial sequence mutations against AlphaFold2 in protein tertiary structure prediction. (2024) Acta Material Medica. (Annual Outstanding Paper of 2024), 3(4), 462-476. https://doi.org/10.15212/AMM-2024-0047

13. Han Y, Zhuang Q, Ren R^#. Approaches for evolutionary, biochemical, and structural analysis of bacterial steroid 5a-reductases. (2023) Methods in Enzymology. 689, 237-261. https://doi.org/10.1016/bs.mie.2023.04.006

14. Wu X, Pang B, You J, Yu L, Ren R^#, Wang H^#, Chen L^#. An LC-MS-based workflow measures the export activity of S1P transporters. (2023) Biochemical and Biophysical Research Communications. 668, 118-124.

    https://doi.org/10.1016/j.bbrc.2023.05.014

15. Yu T, Huang T, Yu L, Nantasenamat C, Anuwongcharoen N, Piacham T, Ren R^#, Chiang Y^#. Exploring the Chemical Space of CYP17A1 Inhibitors Using Chem-informatics and Machine Learning. (2023) Molecules. 28 (4), 1679. https://doi.org/10.3390/molecules28041679

16. Zheng L^*, Meng J^*, Lin M, Lv R, Cheng H, Zou L, Sun J, Li L, Ren R^#, Wang S^#. Structure prediction of the entire proteome of monkeypox variants. (2022) Acta Materia Medica. (Annual Outstanding Cover of 2024) 1 (2), 260-264. https://doi.org/10.15212/AMM-2022-0017

17. Ren R^*,#, Pang B, Li Y. A Glimpse of Structural Biology on Sphingosine-1-Phosphate Metabolism. (2021) Contact. 4, 2515256421995601. https://doi.org/10.1177/2515256421995601

18. Ren R^*, Zhou XH^*, He Y, Ke M, Wu JP, Liu XH, Yan CY, Wu YX, Gong X, Lei XG, Yan SF, Radhakrishnan A, Yan N^#. The crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels. (2015) Science. 349 (6244), 187-191. https://doi.org/10.1126/science.aab1091

19. Xie T^*, Ren R^*, Zhang YY^*, Pang Y, Yan C, Gong X, He Y, Li W, Miao D, Hao Q, Deng H, Wang Z, Wu JW^#, Yan N^#. Molecular mechanism for inhibition of a critical component in the Arabidopsis thaliana abscisic acid signal transduction pathways, SnRK2.6, by protein phosphatase ABI1. (2012) J Biol Chem. 287(1):794-802. https://doi.org/10.1074/jbc.M111.313106