准聘副教授

电话：021-31242916

邮箱：chunmei_chang@fudan.edu.cn

办公地址：复旦大学2号交叉学科楼D7015室

个人简介

2009年获苏州大学学士学位；2014年获浙江大学博士学位；2014-2016年在浙江大学医学院进行博士后研究；2016-2021年在加州大学伯克利分校先后担任博士后、助理项目科学家（assistant project scientist）；2021年12月加入复旦大学代谢与整合生物学研究院。

主要研究方向

主要从事细胞自噬与代谢研究。综合运用分子细胞生物学、生物化学、体外重构和代谢组学等手段，系统研究：1）选择性自噬体形成的分子机理；2）选择性自噬在代谢中的功能及其对代谢紊乱疾病的影响。

荣誉及获奖情况

• 2016年 UC Berkeley Tang Distinguished Scholar，美国

• 2013年国家奖学金，浙江大学，中国

代表性成果

1. C Wu#, H Yang#, C Wang, P Huang, N Yan, R Ren, W Liu, Y Lu*, and C Chang*. ER membrane receptors engage core autophagy machinery to initiate ER phagy. PNAS, 2026 123(4):e2523465123.

2. X Ye#, L Xu#, X Sun#, Y Gai, H Yang, Q Sun, J Song, P Huang, Q Zhou, Y Li, N Li, J Jin, Y Li, W Rao, H Lu, P Wang, C Chang*, and Y Lu*. Co-condensation between transcription factor and cBAF selectively modulates chromatin remodeling and gene expression.Nature Communications, 2026 doi: 10.1038/s41467-025-67322-2. (*共同通讯)

3. W Zheng, M Pu, S Zeng, H Zhang, Q Wang, T Chen, T Zhou, C Chang*, D Neculai*, and W Liu*. S-palmitoylation modulates the function of non-vesicular lipid transporterATG2 during starvation-induced autophagy. EMBO Journal, 2025 44(9):2596-2619. (*共同通讯)

4. Y Lu* and C Chang*. Boosting cargo turnover with receptor mobility. Nature Cell Biology, 2025 27(2): 178-179.

5. C Chang, LE Jensen, and JH Hurley*. Autophagosome biogenesis: out of the black box. Nature Cell Biology, 2021, 23(5): 450-456.

6. C Chang, X Shi, LE Jensen, AL Yokom, D Fracchiolla, S Martens, and JH Hurley*. Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy. Science Advance, 2021, 7(17): eabg4922.

7. X Shi#, C Chang#, AL Yokom#, LE Jensen, and JH Hurley*. The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment. Elife, 2020, 9: e59099. (#共同一作)

8. D Fracchiolla#, C Chang#, JH Hurley*, and S Martens*. A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy. Journal of Cell Biology, 2020, 219(7): e201912098. (#共同一作)

9. C Chang, LN Young, and JH Hurley*. The BARA necessities of PtdIns 3-Kinase activation in autophagy. Autophagy, 2019, 15(6): 1122-1123.

10. C Chang#, LN Young #, KL Morris, S von Bülow, J Schöneberg, H Yamamoto-Imoto, Y Oe, K Yamamoto, S Nakamura, G Stjepanovic, G Hummer, T Yoshimori, and JH Hurley*. Bidirectional control of autophagy by BECN1 BARA domain dynamics. Molecular Cell, 2019, 73(2): 339-353.

11. C Chang, H Su, D Zhang, Y Wang, Q Shen, B Liu, R Huang, T Zhou, C Peng, C Wong, HM Shen, J Lippincott-Schwartz, and W Liu*. AMPK-dependent phosphorylation of GAPDH triggers Sirt1 activation and is necessary for autophagy upon glucose starvation. Molecular Cell, 2015, 60(6): 930-940.

12. W Feng#, C Chang#, D Luo, H Su, S Yu, W Hua, Z Chen, H Hu, and W Liu*. Dissection of autophagy in human platelets. Autophagy 2014,10(4): 642-651. (#共同一作)

    其他

13. LM Strong, C Chang, JF Riley, CA Boecker, TG Flower, CZ Buffalo, X Ren, AK Stavoe, EL Holzbaur, and JH Hurley*. Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy. Elife, 2021, 10: e70372.

14. R Huang, Y Xu, J Qian, W Wan, B Liu, C Chang, T Zhou, J Lippincott-Schwartz, W Liu*. Deacetylation of nuclear LC3 drives autophagy initiation under starvation. Molecular Cell, 2015, 57(3): 456-466.

15. B Liu, M Fang, Y Hu, B Huang, N Li, C Chang, R Huang, X Xu, Z Yang, Z Chen, W Liu*. Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation. Autophagy, 2014, 10(3): 416-430.

16. Y Guo, C Chang, R Huang, B Liu, L Bao, W Liu*. AP1 is essential for generation of autophagosomes from trans-Golgi network. Journal of Cell Science, 2012, 125(7): 1706-1715.