准聘副教授，中组部青年千人，国家重点研发计划（青年项目）首席科学家

   电话：021-31242108

   邮箱：linzhang_huang@fudan.edu.cn

   地址：复旦大学2号交叉学科楼C7019室

个人简介

2014年毕业于清华大学北京协和医学院，获博士学位；2014-2019年，在美国德克萨斯大学西南医学中心从事博士后研究；2019-2020年，在美国德克萨斯大学西南医学中心儿科系担任教职；2020-2025年1月，在复旦大学代谢与整合生物学研究院任青年研究员；2025年2月至今，在复旦大学代谢与整合生物学研究院任准聘副教授。2022年获得科技部国家重点研发计划青年项目的资助。

主要研究方向

主要从事代谢性心血管疾病致病机制的研究，侧重于T2D、动脉粥样硬化等疾病的病理生理相关研究。采用分子生物学、蛋白组学、代谢组学和生物信息学等手段，研究营养物调控代谢性心血管疾病发生发展的机理。重点研究：1. 糖脂跨细胞转运的代谢调控机理与代谢性疾病的干预手段；2. 糖脂代谢紊乱的机体主动调节方式及其作用机制。

代表性成果

1. Yaxin Niu*, Shengmin Hu*, Yanfeng Zhang, Jinbao Yang, Jiarui Zhang, Ruiping He, Li Chen, Lin Xu, Hongfang Zhao, Bing Gan, Ruobing Ren, Ruth JF Loos, Haobin Ye, Xingrong Du, Tongjin Zhao, Peng Li, Antonio Vidal-Puig, Linzhang Huang#. Lactate-activated GPR81/FARP1 signaling drives insulin-independent glucose uptake and metabolic control. Cell Research, 2026, 36(2):137-151. PMID: 41530347.

2. Shanshan Wang, Jiarui Zhang, Weiyi Wang, Dongyu Huang, Xin Zeng, Xiaoqu Chen, Xingang Zhang, Hui Qian, Linghua Meng#, Linzhang Huang#, Chengbin Yang#, Shengming Ma#. Chem-Stamp Empowered Discovery of a Novel ATRA-Based LDLR Up-Regulator for the Treatment of Atherosclerosis. J Med Chem. 2026, 69(15):18431-18449. PMID: 42479778. (# co-corresponding author)

3. Ruixin Liu*, Fangyuan Chang*, Yue Sun, Haibo Yu, Jingyu Guo, Yaxin Niu, Jiting Xiao, Meixi Quan, Huizhen Lv, Chen Chen, Zhaocai Zhou, Linzhang Huang#, Ding Ai#. Flow-responsive protein phosphatase 2A-striatin 3 holoenzyme promotes endothelial low-density lipoprotein transcytosis and atherogenesis. Signal Transduction and Targeted Therapy, 2026. (accepted) DOI: 10.1038/s41392-026-03084-7. (#co-corresponding author).

4. Jiarui Zhang*, Zehui Cao*, Jinbao Yang*, Kuo Zhu, Shuai Liu, Weijie Liu, Jin Lu, Hongfang Zhao, Wei Dai, Chunmei Chang, Haobin Ye, Xingrong Du, Qi Wang, Binghua Jiang, Sijia Wang, Li Jin, Tongjin Zhao, Peng Li, Antonio Vidal-Puig, Yuanting Zheng, Leming Shi, Linzhang Huang#. Glycine–GLRA1–calmodulin signaling regulates endoplasmic reticulum calcium to sustain insulin secretion and β-cell function. Life Metabolism, 2025, 5(2):loaf044. PMID: 42037784.

5. Liming Yu, Lin Xu, Haiyan Chu, Jun Peng, Anastasia Sacharidou, Hsi-hsien Hsieh, Ada Weinstock, Sohaib Khan, Liquan Ma, Jose Gabriel Barcia Duran, Jeffrey McDonald, Erik Nelson, Sunghee Park, Donald McDonnell, Kathryn Moore, Lily Huang, Edward Fisher, Chieko Mineo, Linzhang Huang#, Philip Shaul#. Macrophage-to-endothelial Cell Crosstalk by the Cholesterol Metabolite 27HC Promotes Atherosclerosis in Male Mice. Nature Communications, 2023, 14:4101. PMID: 37491347. (# co-corresponding author)

6. Linzhang Huang, Ken L. Chambliss, Xiaofei Gao, Ivan Yuhanna, Erica Behling-Kelly, Sonia Bergaya, Mohamed Ahmed, Peter Michaely, Kate Luby-Phelps, Anza Darehshouri, Lin Xu, Edward A. Fisher, Woo-ping Ge, Chieko Mineo#, Philip W. Shaul#. SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis. Nature, 2019, 569(7757): 565-569. PMID: 31019307.

7. Yinyuan Ding*, Linzhang Huang*, Xunde Xian*, Ivan S Yuhanna, Catherine R Wasser, Michael Frotscher, Chieko Mineo, Philip W Shaul#, Joachim Herz#. Loss of Reelin protects against atherosclerosis by reducing leukocyte–endothelial cell adhesion and lesion macrophage accumulation. Science Signaling, 2016, 9(419): pp.ra29. PMID: 26980442. (*co-first author)

8. Linzhang Huang, Baoyan Fan, Ang Ma, Philip Shaul, Haibo Zhu#. Inhibition of ABCA1 protein degradation promotes HDL cholesterol efflux capacity and RCT and reduces atherosclerosis in mice. Journal of Lipid Research, 2015, 56(5):986-997. PMID: 25761370.