准聘副教授

  电话：021-31242095

  邮箱：haobin_ye@fudan.edu.cn

  地址：复旦大学2号交叉学科楼C7023室

个人简介

2016-2020年 科罗拉多大学医学院 血液系 博士后

2015年    罗切斯特大学 病理学 博士

主要研究方向

聚焦白血病干细胞的代谢调控机制，挖掘白血病细胞代谢弱点与关键靶点，研发新型代谢干扰药物

荣誉及获奖情况

国家青年千人计划

上海市千人计划

代表性成果

1. Jia A, Zhang X, Zhou JH, Ma Y, Wang J, GongY, Song W, Hu H, Yu Y, Yang H, Lu Y, Huang L, Du X, Chang C, Pei S, Li P, Jordan C T, Zhao TJ, Ye H. Dual Targeting of SLC25A51 and Succinate Dehydrogenase Selectively Depletes Mitochondrial NAD+ to Eradicate KRAS-Driven AML. Cell Metabolism 2026

2. Liu T, Zhou JH, Gong Y, Zhang Y, Ma Y, Zhang X, Minhajuddin M, Song W, Zhuang Z, Vujovic A, Lu Y, Jia A, Guo R, Ren R, Zhou L, Xiong Y, Huang L, Du X, Zhao TJ, Li P, Jordan C T, Ye H. A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential.  Cell Reports 2025

3. Zhang X, Jia A, You J, Zhuang Z, Wang Y, Liu T, Du X, Huang L, Li P, Zhao TJ, Jordan C T, Chen L, Zhou JH, Ye H. Purine metabolites regulate leukemic cell sensitivity toward cytarabine. Haematologica 2025

4. Ye H*, Minhajuddin M, Krug A, Pei S, Culp-Hill R, Amaya M, Inguva, A Ponder J, Bloois E D, Schniedewind B, Amaya M L, Inguva A, Stevens B M, Pollyea D A, Christians U, D'Alessandro A, Jordan C T*. The hepatic microenvironment uniquely protects leukemia cells through induction of growth and survival pathways mediated by LIPG. Cancer Discovery 2021

5. Ye H, Adane B, Khan N, Alexeev E, Nusbacher N, Minhajuddin M, Stevens B M, Winters A C, Lin X, Ashton J M, Purev E, Xing L, Pollyea D A, Lozupone C A, Serkova N J, Colgan S P, Jordan C T. Subversion of systemic glucose metabolism as a mechanism to support the growth of leukemia cells. Cancer Cell 2018

6. Ye H, Adane B, Khan N, Sullivan T, Minhajuddin M, Gasparetto M, Stevens B M, Pei S, Balys M, Ashton J M, Klemm D J, Woolthuis C M, Stranahan A W, Park C Y, Jordan C T. Leukemic stem cells evade chemotherapy by metabolic adaptation to an adipose tissue niche. Cell Stem Cell 2016