青年研究员   

电话：021-31242086   

邮箱：he_huang@fudan.edu.cn   

地址：复旦大学2号交叉学科楼D7023室

个人简介

黄河，主攻基于质谱技术的代谢组学/脂质组学/蛋白组学的方法学研究，2012年获武汉大学化学专业学士学位，2017年获美国Akron大学分析化学博士学位，2017年起在美国哈佛大学医学院进行博士后研究并兼任美国贝斯以色列女执事医学中心（Beth Israel Deaconess Medical Center）质谱分析中心助理研究员，同期担任F1000细胞生物学方向评审助理，2019年7月全职回国任复旦大学代谢与整合生物学研究所青年研究员。致力于高通量的液相色谱-质谱联用技术的脂质组学的方法学研究和相关临床应用，应用范围包括但不限于癌症、肥胖、糖尿病、炎症、心血管疾病、神经退行性疾病等。主要工作包括：提出基于系统内相关性策略的脂质组数据挖掘方法（Small Methods 2021），基于体外/体内的稳定同位素标记方法建立的新型靶向和非靶向代谢/脂质流组学（Nature Protocols 2019, Methods and Protocols 2020）。并将脂质组学方法应用于多种临床疾病的靶点发现和诊断中（Neuro-Oncology Advances 2022, Metabolites 2022, Life Science Alliance 2021）。

主要研究方向

主要研究基于高分辨质谱技术的代谢组学和脂质组学方法学研究。包括靶向/非靶向的代谢组学和脂质组学技术，以及组学数据相关的生物统计学、生物信息学分析。

代表性成果

1. Xiao Guo#, Yuemeng Zhu#, Lu Guo#, Yiwen Qi#, Xiaocheng Liu, Jinhui Wang, Jiangtao Zhang, Linlin Cui, Yueyang Shi, Qichu Wang, Cenxi Liu, Guangxing Lu, Yilian Liu, Tao Li, Shangyu Hong, Yingying Qin, Xuelian Xiong, Hao Wu, Lin Huang, He Huang*, Chao Gu*, Bin Li*, Jin Li*, BCAA insufficiency leads to premature ovarian insufficiency via ceramide-induced elevation of ROS, EMBO Molecular Medicine, 2023, e17450.

2. Liying Zhou#, Qing Li#, Jingshen Xu, Shuaikang Wang, Zhiqiang Song, Xinyi Chen, Yan Ma, Zhiguang Lin, Bobin Chen*, He Huang*, Cerebrospinal Fluid Metabolic Markers Predict Prognosis behavior of Primary CNS Lymphoma with HD-MTX Based Chemotherapeutic Treatment, Neuro-Oncology Advances, 2022, vdac181, doi.org/10.1093/noajnl/vdac181.

3. Zhengqing Song, Shuaikang Wang, Lili Lu, Jingshen Xu, Qiwen Zhou, Weiqi Lu, Hanxing Tong, Yong Zhang, Wenshuai Liu, Zhiming Wang, Wei Li, Yang You, Chenlu Zhang, Xi Guo, Rongkui Luo, Yingyong Hou, Chunmeng Wang, Yuexiang Wang, Lei Sun*, He Huang*, Yuhong Zhou*, Lipidomics and Transcriptomics Differ Liposarcoma Differentiation Characteristics That Can Be Altered by Pentose Phosphate Pathway Intervention, Metabolites, 2022, 12(12), 1227.

4. Yuqin Wang, Xinzhi Li, Cenxi Liu, Liying Zhou, Lei Shi, Zhiguo Zhang, Long Chen, Ming Gao, Lanyue Gao, Yuanyuan Xu, He Huang, Jin Li, and Zheng Chen*, WTAP Regulates Postnatal Development of Brown Adipose Tissue by stabilizing METTL3 in mice, Life Metabolism, 2022, loac028, doi.org/10.1093/lifemeta/loac028.

5. Xiaoyan Wang, Wenwen Kong, Yuan Wang, Jinhui Wang, Luyao Zhong, Kangwen Lao, Xianxin Dong, Dingyu Zhang, He Huang, Beixin Mo, Yu Yu, Guodong Ren, Uridylation and the SKI complex orchestrate the Calvin cycle of photosynthesis through RNA surveillance of TKL1 in Arabidopsis, Proc. Natl. Acad. Sci. USA., 2022, 119(38):e2205842119.

6. Xinzhi Li, Kaixin Ding, Xueying Li, Bingchuan Yuan, Yuqin Wang, Zhicheng Yao, Shuaikang Wang, He Huang, Bolin Xu, Liwei Xie, Tuo Deng, Xiao-wei Chen, Zheng Chen*. Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH). Nature Communications, 2022, 13: 4549.

7. Chuanyou Yi#, Dandan Li#, Xiao Guo#, Jinhui Wang, Cenxi Liu, Guangxing Lu, Yan Sun, He Huang*, Shangyu Hong*, Jin Li*. The Storage Conditionns of High-Fat Diet Are the Key Factors for Diet-Induced Obesity and Liver Damage. Nutrients. 2022, 14(11): 2222.

8. Dandan Li#, Chuanyou Yi#, He Huang, Jin Li*, Shangyu Hong*, Hepatocyte-specific depletion of Nnmt protects mice from non-alcoholic steatohepatitis, Journal of Hepatology, 2022, 77(3):882-884.

9. Ziyang Lu#, Fanghe Lin#, Tao Li#, Jinhui Wang, Cenxi Liu, Guangxing Lu, Bin Li, Mingpei Pan, Shaohua Fan, Junqiu Yue, He Huang, Jia Song*, Chao Gu*, Jin Li*, Identification of clinical and molecular features of recurrent serous borderline ovarian tumour, eClinicalMedicine, 2022, doi.org/10.1016/j.eclinm.2022.101377.

10. Fengsheng Li, Jia Song, Yingkun Zhang, Shuaikang Wang, Jinhui Wang, Li Lin, Chaoyong Yang*, Peng Li*, He Huang*, LINT-web: A Web-Based Lipidomic Data Mining Tool Using Intra-Omic Integrative Correlation Strategy, Small Methods, 2021, 2100206.  

11. Qing Cong, Xiao Guo, Shengwei Zhang, Jinhui Wang, Yi Zhu, Lili Wang, Guangxing Lu, Yufeng Zhang, Wei Fu, Liying Zhou, Shuaikang Wang, Cenxi Liu, Jia Song, Chaoyong Yang, Chi Luo, Ting Ni, Long Sui*, He Huang*, Jin Li*, HCV poly U/UC sequence–induced inflammation leads to metabolic disorders in vulvar lichen sclerosis, Life Science Alliance, 2021, 4, e202000906.  

12. He Huang#, Min Yuan, Phillip Seitzer, Susan Ludwigsen, John Asara*, IsoSearch: An Untargeted and Unbiased Metabolite and Lipid Isotopomer Tracing Strategy from HR-LC-MS/MS Datasets, Methods and Protocols, 2020, 3, 54.

13. Min Yuan#, Daniel M. Kremer#, He Huang#, Susanne B. Breitkopf, Issam Ben Sahra, Brendan D. Manning, Costas A. Lyssiotis, John M. Asara, Ex Vivo and In Vivo Stable Isotope Labelling of Central Carbon Metabolism and Related Pathways with analysis by LC-MS/MS, Nature Protocols, 2019 Feb;14(2):313-330. doi: 10.1038/s41596-018-0102-x. (*Co-first author)

14. Wen Cai Zhang, Julie Wells, Kin-Hoe Chow, He Huang, Min Yuan, Tanvi Saxena, Mary Ann Melnick, Katerina Politi, John Asara, Daniel Costa, Carol Bult, Frank Slack, miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma, Nature Metabolism, 2019, April (1) 460–474. doi: 10.1038/s42255-019-0052-9.  

15. He Huang, Alexandra Taraboletti, Leah P. Shriver, Dimethyl fumarate modulates antioxidant and lipid metabolism in oligodendrocytes, Redox Biology, 2015 (5) 169-175, doi:10.1016/j.redox.2015.04.011.