教授，主任医师，中国工程院院士

国家杰出青年基金获得者

电话：021-81875361

邮箱：hywangk@vip.sina.com

地址：上海市长海路225号东方肝胆外科医院三号楼6楼

个人简历

王红阳教授，女，主任医师，博士生导师，肿瘤学、分子生物学专家，中国工程院院士，发展中国家科学院院士，国家杰出青年基金获得者。现任国家肝癌科学中心主任、国际合作生物信号转导研究中心主任。兼任中国科协女科技工作者协会会长，中国抗癌协会副理事长，中国医师协会精准医学专业委员会主任委员。

长期从事肿瘤的基础与临床研究，对肿瘤的炎-癌转化、信号网络调控和肝癌诊断试剂研发等有重要建树。在国际有影响的主流期刊发表SCI论文200余篇；近五年申报发明专利28项，已获授权12项（国际专利3项），主持研发的Glypican-3肝癌诊断试剂已获国家食品药品监督管理总局（CFDA）批复临床应用（是我国第一个具有完全自主产权获批的肝癌诊断试剂盒）。先后主持国家和省部级重大、重点科技攻关项目十余项。

主要研究方向

主要从事恶性肿瘤的基础与临床研究，包括肝胆肿瘤发病机制，细胞炎-癌转化分子机理、细胞信号转导网络调控、肿瘤功能基因组学和肿瘤代谢，以及肿瘤早期诊断标志物的研发。

获奖情况

 以第一完成人获首届国家科学技术进步奖创新团队奖、国家自然科学二等奖、上海市自然科学一等奖、上海医学科技一等奖等9项，获全国三八红旗手标兵、总后勤部“科技金星”、上海市“十大科技精英”和上海市“优秀学科带头人”等称号，获韩国爱茉莉太平洋杰出女科学家奖，巾帼创新奖和首届“五洲女医师奖” 等。曾先后荣立一等功、二等功和三等功。

代表性著作

1. Tian-Yi Jiang, Yu-Fei Pan, Zheng-Hua Wan, Yun-Kai Lin, Bin Zhu, Zhen-gang Yuan,Yun-Han Ma, Yuan-Yuan Shi, Tian-Mei Zeng, Li-Wei Dong*, Ye-Xiong Tan& Hong-Yang Wang*. PTEN status determines the chemosensitivity to proteasome inhibition in cholangiocarcinoma. Science Translational Medicine 2020 [Epub ahead of print]

2. Xiaofang Zhao, Wenhao Qin, Youhai Jiang, Zhishi Yang, Bo Yuan, Rongyang Dai, Hao Shen, Yao Chen, Jing Fu*, Hongyang Wang*. ACADL plays a tumor-suppressor role by targeting Hippo/YAP signaling in hepatocellular carcinoma. npj Precision Oncology 2020 Mar 25;4:7.

3. Qin WH, Yang ZS, Li M, Chen Y, Zhao XF, Qin YY, Song JQ, Wang BB, Yuan B, Cui XL, Shen F, He J, Bi YF, Ning G*, Fu J*, Wang HY*.High Serum Levels of Cholesterol Increase Antitumor Functions of Nature Killer Cells and Reduce Growth of Liver Tumors in Mice. Gastroenterology. 2020 Jan 20. pii: S0016-5085(20)30118-9. doi: 10.1053/j.gastro.2020.01.028. [Epub ahead of print]

4. Cai J, Chen L, Zhang Z, Zhang X, Lu X, Liu W, Shi G, Ge Y, Gao P, Yang Y, Ke A, Xiao L, Dong R, Zhu Y, Yang X, Wang J, Zhu T, Yang D, Huang X, Sui C, Qiu S, Shen F, Sun H, Zhou W, Zhou J, Nie J, Zeng C, Stroup EK, Zhang X, Chiu BC, Lau WY, He C, Wang H, Zhang W, Fan J. Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma.  Gut. 2019 Jul 29. [Epub ahead of print] （IF=17.1）

5. Wei Y, Chen X, Liang C, Ling Y, Yang X, Ye X, Zhang H, Yang P, Cui X, Ren Y, Xin X, Li H, Wang R, Wang W, Jiang F, Liu S, Ding J, Zhang B, Li L*, Wang H*.A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma. Hepatology. 2020 Jan;71(1):130-147.（IF= 14.079）

6. Cheng Z, He Z, Cai Y, Zhang C, Fu G, Li H, Sun W, Liu C, Cui X, Ning B, Xiang D, Zhou T, Li X, Xie W*, Wang H*, Ding J*. Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors. Cell Res. 2019 Feb;29(2):124-135. （IF=15.4 ）

7. Liu J, Jiang J, Mo J, Liu D, Cao D,Wang H, He Y, Wang H*. Global DNA 5-hydroxymethylcytosine and 5-formylcytosine contents are decreased in the early stage of hepatocellular carcinoma. Hepatology. 2019 Jan;69(1):196-208（IF= 14.079）

8. Fu GB, Huang WJ, Zeng M, Zhou X, Wu HP, Liu CC, Wu H, Weng J, Zhang HD, Cai YC, Ashton C, Ding M, Tang D, Zhang BH, Gao Y, Yu WF, Zhai B, He ZY, Wang HY*, Yan HX*. Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens. Cell Res. 2019 Jan;29(1):8-22（IF=15.4 ）

9. Fang T, Lv H, Lv G, Li T, Wang C, Han Q, Yu L, Su B, Guo L, Huang S, Cao D, Tang L, Tang S, Wu M, Yang W*, Wang H*.Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer. Nat Commun. 2018 Jan 15;9(1):191. （IF=12.353）

10. Wang B, Fu J, Yu T, Xu A, Qin W, Yang Z, Chen Y*, Wang H*. Contradictory Effects of Mitochondria- and Non-mitochondria-targeted Antioxidants on Hepatocarcinogenesis by Altering DNA Repair. Hepatology 2017 Sep 12. doi: 10.1002/hep.29518. （IF=11.711）

11. Xi-Meng Lin, Liang Hu, Jin Gu, Ruo-Yu Wang, Liang Li, Jing Tang, Bao-Hua Zhang, Xing-Zhou Yan, Yan-Jing Zhu, Cong-Li Hu, Wei-Ping Zhou, Frank J Gonzalez, Meng-Chao Wu, Hong-Yang Wang*, and Lei Chen*.Choline Kinase Alpha-Driven Assembly of EGFR and mTORC2 Promotes Hepatocellular Carcinoma Metastasis and Drug Resistance. Gastroenterology 2017 Apr 1, 152:1187-1202（IF=18.187）

12. Yang Y, Chen L, Gu J, Zhang H, Yuan J, Lian Q, Lv G, Wang S, Wu Y, Yang YT, Wang D, Liu Y, Tang J, Luo G, Li Y, Hu L, Sun X, Wang D, Guo M, Xi Q, Xi J, Wang H, Zhang MQ, Lu ZJ*. Recurrently deregulated lncRNAs in hepatocellular carcinoma. Nat Commun. 2017 Feb 13;8:14421. doi: 10.1038/ncomms14421（IF=11.47）

13. Wu H, Zhou X, Fu GB, He ZY, Wu HP, You P, Ashton C, Wang X, Wang HY*, Yan HX*. Reversible transition between hepatocytes and liver progenitors for in vitro hepatocyte expansion. Cell Res. 2017 May;27(5):709-712（IF=15.606）

14. Ke S, Chen S, Dong Z, Hong CS, Zhang Q, Tang L, Yang P, Zhai J, Yan H, Shen F, Zhuang Z, Wen W*, Wang H*.Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations. Hepatology. 2017 Jan;65(1):134-151（IF=11.711）

15. Hou G, Chen L, Liu G, Li L, Yang Y, Yan HX, Zhang HL, Tang J, Yang YC, Lin X, Chen X, Luo GJ, Zhu Y, Tang S, Zhang J, Liu H, Gu Q, Zhao LH, Li Y, Liu L*, Zhou W*, Wang H*. Aldehyde Dehydrogenase-2 (ALDH2) Opposes HCC Progression By Regulating AMPK Signaling. Hepatology. 2017 May;65(5):1628-1644（IF=11.055）

16. Yun-Han Ma, Wei-Tao Dou, Yu-Fei Pan, Li-Wei Dong, Ye-Xiong Tan, Xiao-Peng He,* He Tian, and Hong-Yang Wang* . Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues. Adv Mater. 2017 Feb;29(5). doi: 10.1002/adma.201604253. Epub 2016 Nov 21. （IF=18.96）

17. Qu L, Ding J, Chen C, Wu ZJ, Liu B, Gao Y, Chen W, Liu F, Sun W, Li XF, Wang X, Wang Y, Xu ZY, Gao L, Yang Q, Xu B, Li YM, Fang ZY, Xu ZP, Bao Y, Wu DS, Miao X, Sun HY, Sun YH, Wang HY*, Wang LH*. Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA. Cancer Cell. 2016 May 9;29(5):653-68 (IF= 23.214)

18. Ling-Hao Zhao, Xiao Liu, He-Xin Yan, Wei-Yang Li, Xi Zeng, Yuan Yang, Jie Zhao,Shi-Ping Liu, Xue-Han Zhuang, Chuan Lin, Chen-Jie Qin, Yi Zhao, Ze-Ya Pan, Gang Huang, Hui Liu,Jin Zhang, Ruo-Yu Wang, Yun Yang, Wen Wen, Gui-Shuai Lv, Hui-Lu Zhang, Han Wu, Shuai Huang,Ming-Da Wang, Liang Tang, Hong-Zhi Cao, Ling Wang, Tin-Lap Lee, Hui Jiang, Ye-Xiong Tan,Sheng-Xian Yuan, Guo-Jun Hou, Qi-Fei Tao, Qin-Guo Xu, Xiu-Qing Zhang, Meng-Chao Wu, Xun Xu,Jun Wang, Huan-Ming Yang, Wei-Ping Zhou & Hong-Yang Wang* . Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun. 2016 Oct 5;7:12992（IF=11.47）

19. Yang C, Tan YX, Yang GZ, Zhang J, Pan YF, Liu C, Fu J, Chen Y, Ding ZW, Dong LW, Wang HY*. Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.J Exp Med. 2016 May 2;213(5):859-75. doi: 10.1084/jem.20151208. Epub 2016 Apr 18 (IF= 11.24)

20. Yang Y, Lin X, Lu X, Luo G, Zeng T, Tang J, Jiang F, Li L, Cui X, Huang W, Hou G, Chen X, Ouyang Q, Tang S, Sun H, Chen L, Gonzalez FJ, Wu M, Cong W, Chen L*, Wang H*. Interferon-microRNA signalling drives liver precancerous lesion formation and hepatocarcinogenesis. Gut. 2016 Jul;65(7):1186-201 (IF=14.921)