青年副研究员
邮箱：shiqing_fdu@fudan.edu.cn
地址：复旦大学2号交叉学科楼D7019室

个人简介

2023.9- 复旦大学代谢与整合生物学研究院，青年副研究员

2021.8-2023.8 复旦大学生命科学学院，博士后

2016.9-2021.7 复旦大学生命科学学院，理学博士

2012.9-2016.6 吉林大学生命科学学院，理学学士

主要研究方向

蛋白翻译后修饰的分子机制研究，从遗传学角度阐述基因突变与疾病发生发展之间的关系。

荣誉及获奖情况

• 2022年    国家自然科学基金青年科学基金资助

• 2021年    中国博士后科学基金面上资助

• 2021年    中国博士后特别资助（站中）
  

代表性成果

1. Shi Q#, Jin X#, Zhang P#, Li Q#, He H, Zhao X, Lv Z, Zhao S, Li Y, Gao K*, Wang C*. SPOP Mutations Promote p62/SQSTM1-dependent Autophagy and Nrf2 Activation in Prostate Cancer. Cell Death Differ. 2022 Jun;29(6):1228-1239.

2. Shi Q#, Zhu Y#, Ma J#, Chang K, Ding D, Bai Y, Gao K, Zhang P, Mo R, Feng K, Zhao X, Zhang L, Sun H, Jiao D, Chen Y, Sun Y, Zhao S, Huang H, Li Y, Ren S, Wang C*. Prostate Cancer-associated SPOP Mutations Enhance Cancer Cell Survival and Docetaxel Resistance by Upregulating Caprin1-dependent Stress Granule Assembly. Mol Cancer. 2019 Nov 26;18(1):170.

3. Kun Gao# , Qing Shi#, Ye Gu #, Wanqi Yang, Yuanlong He, Zeheng Lv, Yan Ding, Wenxin Cao, Chenji Wang*, Xiaoping Wan*. SPOP mutations promote tumor immune escape in endometrial cancer via the IRF1-PD-L1 axis. Cell Death Differ. 2023 Feb;30(2):475-487. 

4. Ma J#, Shi Q#, Cui G#, Sheng H, Botuyan MV, Zhou Y, Yan Y, He Y, Wang L, Wang Y, Georges Mer, Ye D*, Wang C*, Huang H*. SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition. Nat Comm. 2021 Oct 1;12(1):5779.

5. Jin X#, Qing S#, Li Q, Zhuang H, Shen L, Li J, Qi H, Lin T, Lin Z, Wang J, Cao X, Yang J, Ma Q, Cong L, Xi Y, Fang S, Meng X, Gong Z, Ye M, Wang S, Wang C*, Gao K*. Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP-HIPK2 axis. Nucleic Acids Res. 2021 Jul 9;49(12):6788-6803.

6. Jin X#, Shi Q#, Li Q, Zhou L, Wang J, Jiang L, Zhao X, Feng K, Lin T, Lin Z, Zhuang H, Yang J, Hu C, Zhang L, Shen L, Lu Y, Zhu J, Wang H, Qi H, Meng X, Xi Y, Pan J, Fang S, Tian H, Zhou C, Zhang P, Gao K, Zhao S, Li Y, Gong Z*, Wang C*. CRL3-SPOP Ubiquitin Ligase Complex Suppresses the Growth of Diffuse Large B-cell Lymphoma by Negatively Regulating the MyD88/NF-κB Signaling. Leukemia. 2020 May; 34(5): 1305- 1314.

7. Kai Feng#, Qing Shi#, Dongyue Jiao, Yingji Chen, Wanqi Yang, Ke Su, Yalan Wang, Yan Humang, Pingzhao Zhang, Yao Li, Chenji Wang*;  Pingzhao Zhang *. SPOP Inhibits BRAF-dependent Tumorigenesis through Promoting Non-degradative Ubiquitination of BRAF. Cell & Biosci. 2022 Dec 30;12(1):211. doi: 10.1186/s13578-022-00950-z.